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- W2162607777 abstract "Over the last two decades much research has focused on the role of substance P in pain and on the development of substance P antagonists as novel analgesics. Despite the identification of high affinity and selective substance P (NK1) receptor antagonists and a plethora of preclinical data supporting an analgesic profile of these agents, the outcome from clinical trials has been extremely disappointing with no clear analgesic efficacy being observed in a variety of pain states. This has led the pain community to seriously question the predictability and utility of preclinical pain assays, especially for novel targets. This chapter will review the animal studies and clinical trials with NK1 receptor antagonists and suggests possible reason s for the apparent mismatch between preclinical and clinical studies in pain." @default.
- W2162607777 created "2016-06-24" @default.
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- W2162607777 date "2004-01-01" @default.
- W2162607777 modified "2023-09-25" @default.
- W2162607777 title "Substance P (NK1) Receptor Antagonists—Analgesics or Not?" @default.
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- W2162607777 doi "https://doi.org/10.1007/978-3-642-18891-6_13" @default.
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