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- W2162615610 abstract "Plasma-to-tissue transport of radioactively labelled albumin has been used to study the effect of increased venous pressure on transcapillary albumin transport. Venous pressure was increased by inflating a balloon catheter in the inferior caval vein. Plasma-to-tissue transport of albumin was taken as the extravascular distribution space (EValb) for 125I-labelled human serum albumin (I-HSA) after I h. Venous pressure was increased from 2 to 20 mmHg in the experimental group. Interstitial fluid volume (IFV) was measured as the extravascular distribution space for 51Cr-EDTA. In control EValb was 9.24 × 10--3 ml g-1 d. wt (SD = 1.28, n= 8) and 3.67 × 10--3 ml g-1 d.wt (SD = 0.94, n= 8) in skin and skeletal muscle, respectively. Increasing venous pressure raised EValb and IFV in skin and skeletal muscle, but the increase in EValb was about 3 and 5 % of the rise in IFV, resulting in capillary reflection coefficients for albumin of 0.94 in skin and 0.98 in skeletal muscle. The low transcapillary albumin transport relative to water transport is-compatible with a two-pore model of transcapillary exchange where large pores (250 Å) accounts for less than 5.5 and 2.5% of the total capillary filtrate of fluid in skin and skeletal muscle, respectively." @default.
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- W2162615610 date "1988-11-01" @default.
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- W2162615610 title "Transcapillary albumin extravasation in rat skin and skeletal muscle: effect of increased venous pressure" @default.
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- W2162615610 doi "https://doi.org/10.1111/j.1748-1716.1988.tb08504.x" @default.
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