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- W2162637824 abstract "The physiological underpinning for cardiac resynchronization therapy (CRT) began with Carl Wiggers in 1925. He showed that when contraction of the heart was induced by direct cardiac electric stimulation, the early phase of contraction of the heart was slowed and myocardial tension developed more gradually.1 Wiggers explained these findings by differences in the order of excitation of the ventricle. Subsequent studies by a number of investigators highlighted the fact that a left bundle-branch block conduction pattern was associated with dyssynchronous contraction that exacerbated left ventricular systolic dysfunction. Few people appreciate the fact that Dr Morton Mower, who was involved in the development of the implantable cardioverter defibrillator,2,3 also developed the patent for cardiac resynchronization therapy in 19904 that was assigned to CPI/Guidant and subsequently licensed to Medtronic.In 1994, Cazeau et al5 reported 1 patient with widened QRS and advanced heart failure who achieved dramatic improvement with biventricular pacing. Various short-term animal and clinical hemodynamic studies showed significant improvement in cardiac function when both right and left ventricles of a diseased heart with conduction disturbance were preexcited (biventricular pacing),6 and similar findings were observed recently with univentricular left ventricular stimulation in the compromised heart …" @default.
- W2162637824 created "2016-06-24" @default.
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- W2162637824 date "2013-03-12" @default.
- W2162637824 modified "2023-09-25" @default.
- W2162637824 title "Narrow QRS Is Not the Right Substrate for Cardiac Resynchronization Therapy" @default.
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- W2162637824 doi "https://doi.org/10.1161/circulationaha.113.001363" @default.
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