Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162641910> ?p ?o ?g. }
- W2162641910 endingPage "755" @default.
- W2162641910 startingPage "751" @default.
- W2162641910 abstract "Interferon-γ (IFN-γ) is critical for defense against pathogens, but the molecules that mediate its antimicrobial responses are largely unknown. IGTP is the prototype for a family of IFN-γ-regulated genes that encode 48-kDa GTP-binding proteins that localize to the endoplasmic reticulum. We have generated IGTP-deficient mice and found that, despite normal immune cell development and normal clearance of Listeria monocytogenes and cytomegalovirus infections, the mice displayed a profound loss of host resistance to acute infections of the protozoan parasite Toxoplasma gondii . By contrast, IFN-γ receptor-deficient mice have increased susceptibility to all three pathogens. Thus, IGTP defines an IFN-γ-regulated pathway with a specialized role in antimicrobial resistance." @default.
- W2162641910 created "2016-06-24" @default.
- W2162641910 creator A5001421633 @default.
- W2162641910 creator A5016487212 @default.
- W2162641910 creator A5017948966 @default.
- W2162641910 creator A5021241224 @default.
- W2162641910 creator A5022917166 @default.
- W2162641910 creator A5041171040 @default.
- W2162641910 creator A5044411423 @default.
- W2162641910 creator A5045104926 @default.
- W2162641910 creator A5062451440 @default.
- W2162641910 creator A5062871652 @default.
- W2162641910 creator A5064843394 @default.
- W2162641910 creator A5081911372 @default.
- W2162641910 creator A5082274877 @default.
- W2162641910 creator A5085532042 @default.
- W2162641910 creator A5086047716 @default.
- W2162641910 creator A5086290367 @default.
- W2162641910 creator A5090914300 @default.
- W2162641910 creator A5091344747 @default.
- W2162641910 date "2000-01-18" @default.
- W2162641910 modified "2023-10-01" @default.
- W2162641910 title "Pathogen-specific loss of host resistance in mice lacking the IFN-γ-inducible gene IGTP" @default.
- W2162641910 cites W1509094720 @default.
- W2162641910 cites W1514456064 @default.
- W2162641910 cites W1544874562 @default.
- W2162641910 cites W1545910465 @default.
- W2162641910 cites W1580262749 @default.
- W2162641910 cites W1586093731 @default.
- W2162641910 cites W1894552802 @default.
- W2162641910 cites W1915939874 @default.
- W2162641910 cites W1997308847 @default.
- W2162641910 cites W2003565653 @default.
- W2162641910 cites W2010708956 @default.
- W2162641910 cites W2026318599 @default.
- W2162641910 cites W2028500185 @default.
- W2162641910 cites W2046105178 @default.
- W2162641910 cites W2068871282 @default.
- W2162641910 cites W2074370296 @default.
- W2162641910 cites W2075413744 @default.
- W2162641910 cites W2089262366 @default.
- W2162641910 cites W2103565638 @default.
- W2162641910 cites W2103866208 @default.
- W2162641910 cites W2117079340 @default.
- W2162641910 cites W2121706409 @default.
- W2162641910 cites W2134768631 @default.
- W2162641910 cites W2153391962 @default.
- W2162641910 cites W2167049054 @default.
- W2162641910 cites W2346867432 @default.
- W2162641910 cites W2395362254 @default.
- W2162641910 cites W4238915259 @default.
- W2162641910 cites W4313305984 @default.
- W2162641910 doi "https://doi.org/10.1073/pnas.97.2.751" @default.
- W2162641910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15402" @default.
- W2162641910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10639151" @default.
- W2162641910 hasPublicationYear "2000" @default.
- W2162641910 type Work @default.
- W2162641910 sameAs 2162641910 @default.
- W2162641910 citedByCount "257" @default.
- W2162641910 countsByYear W21626419102012 @default.
- W2162641910 countsByYear W21626419102013 @default.
- W2162641910 countsByYear W21626419102014 @default.
- W2162641910 countsByYear W21626419102015 @default.
- W2162641910 countsByYear W21626419102016 @default.
- W2162641910 countsByYear W21626419102017 @default.
- W2162641910 countsByYear W21626419102018 @default.
- W2162641910 countsByYear W21626419102019 @default.
- W2162641910 countsByYear W21626419102020 @default.
- W2162641910 countsByYear W21626419102021 @default.
- W2162641910 countsByYear W21626419102022 @default.
- W2162641910 countsByYear W21626419102023 @default.
- W2162641910 crossrefType "journal-article" @default.
- W2162641910 hasAuthorship W2162641910A5001421633 @default.
- W2162641910 hasAuthorship W2162641910A5016487212 @default.
- W2162641910 hasAuthorship W2162641910A5017948966 @default.
- W2162641910 hasAuthorship W2162641910A5021241224 @default.
- W2162641910 hasAuthorship W2162641910A5022917166 @default.
- W2162641910 hasAuthorship W2162641910A5041171040 @default.
- W2162641910 hasAuthorship W2162641910A5044411423 @default.
- W2162641910 hasAuthorship W2162641910A5045104926 @default.
- W2162641910 hasAuthorship W2162641910A5062451440 @default.
- W2162641910 hasAuthorship W2162641910A5062871652 @default.
- W2162641910 hasAuthorship W2162641910A5064843394 @default.
- W2162641910 hasAuthorship W2162641910A5081911372 @default.
- W2162641910 hasAuthorship W2162641910A5082274877 @default.
- W2162641910 hasAuthorship W2162641910A5085532042 @default.
- W2162641910 hasAuthorship W2162641910A5086047716 @default.
- W2162641910 hasAuthorship W2162641910A5086290367 @default.
- W2162641910 hasAuthorship W2162641910A5090914300 @default.
- W2162641910 hasAuthorship W2162641910A5091344747 @default.
- W2162641910 hasBestOaLocation W21626419102 @default.
- W2162641910 hasConcept C104317684 @default.
- W2162641910 hasConcept C158617107 @default.
- W2162641910 hasConcept C159047783 @default.
- W2162641910 hasConcept C159654299 @default.
- W2162641910 hasConcept C170493617 @default.
- W2162641910 hasConcept C203014093 @default.
- W2162641910 hasConcept C2776178377 @default.