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• W2162667734 abstract "The Journal of Clinical Pharmacology and New DrugsVolume 13, Issue 11 p. 439-444 Review of the Toxicity of Hexachlorophene, Including Its Neurotoxicity R. D. KIMBROUGH M.D., R. D. KIMBROUGH M.D. Chamblee, Ga. Dr. Kimbrough is with the Environmental Protection Agency, 4770 Buford Highway, Chamblee, Georgia 30341.Search for more papers by this author R. D. KIMBROUGH M.D., R. D. KIMBROUGH M.D. Chamblee, Ga. Dr. Kimbrough is with the Environmental Protection Agency, 4770 Buford Highway, Chamblee, Georgia 30341.Search for more papers by this author First published: November‐December 1973 https://doi.org/10.1002/j.1552-4604.1973.tb00196.xCitations: 5 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Gump, W. S.: Toxicological properties of hexachlorophene. J. Soc. Cosmetic Chemists 20: 173 (1969). 2 Kimbrough, R. D.: Review of the toxicity of hexachlorophene. Arch. Environ. Health, 23: 119 (1971). 3 Larson, D. L., Abston, S., and Bachmann, R. C.: Hexachlorophene absorption from the burn wound. In Research in Burns, Hans Huber Publishers, Bern, Stuttgart, Vienna, 1971, page 619. 4 Lockhart, J. D.: How toxic is hexachlorophene? Pediatrics, 50: 229 (1972). 5 Mullick, F. G.: Hexachlorophene toxicity—human experience at the AFIP. Pediatrics, 51: 395 (1973). 6 Korlof, B., and Winsten, J.: The complications of pHisoIIex, Scand. J. Plast. Reconstr. Surg. 1: 78 (1967). 7 Newcomer, V. D., Lindberg, M. C., and Sternberg, T. H.: A melanosis of the face (chloasma). Arch. Derm. 83: 284 (1961). 8 McDonald, H. P., and Woodruff, M. W.: Scrotal reaction to pHisoHex, J. Uro. 86: 266 (1961). 9 Baker, H., Ive, F. A., Lloyd, M. J.: Primary irritant dermatitis of the scrotum due to hexachlorophene. Arch. Derm. 99: 693 (1969). 10 Gaines, T. B., Kimbrough, R. D., and Linder, R. E.: The oral and dermal toxicity of hexachlorophene in rats. Toxicol. Appl. Pharmacol. 25: 332 (1973). 11 Udall, V., and Malone, J. C.: Optic nerve atrophy after drug treatment. In The Problems of Species Difference and Statistics in Toxicology. Vol. XI. Excerpta Medica Foundation, Amsterdam, 1970, p. 224. 12 Kimmel, C. A., Moore, W., and Stara, J. F.: Hexachlorophene teratogenicity in rats. Lancet 2: 765 (1972). 13 Oakley, G. P., and Shepard, T. H.: Possible teratogenicity of hexachlorophene in rats. Teratology 5: 264 (1972). (12th Annual Meeting of Teratology Society, Abstract.). 14 Carroll, F. E., Salak, W. W., Howard, J. M., and Pairent, F. W.: Absorption of antimicrobial agents across experimental wounds. Surg. Gynecol. Obstet. 125: 974 (1967). 15 Lockhart, J. D.: Personal communication. 16 Balazs, T.: Measurements of acute toxicity. In G. E. Paget: Methods in Toxicology, Philadelphia, F. A. Davis Co., P. 60, 1970. 17 Larson, D. L.: Studies show hexachlorophene causes burn syndrome. Hospitals J. Amer. Hosp. Assoc. 42: 63 (1968). 18 Hanig, J. P., Morrison, J. M. Jr., and Krop, S.: Attenuation of CNS toxicity of hexachlorophene in the rat and the cat. Presented at the 12th Annual Meeting Soc. Tox. March 18–22, New York, 1973. Abstract #3. 19 Kimbrough, R. D., and Gaines, T. B.: The effect of hexachlorophene on the rat brain. Light microscopy and ultrastructure. Arch. Environ. Health, 23: 114 (1971). 20 Kimbrough, R. D.: Review of recent evidence of toxic effects of hexachlorophene. Pediatrics 51: 391 (1973). 21 Suggs, J., and Girling, E. (EPA, 4770 Buford Hwy. Chamblee, Ga. 30341). Personal communication. 22 U.S. Food and Drug Administration: Hexachlorophene and newborns. Bulletin, Dec. 1971. 23 Santolucito, J. A.: Electroencephalograms and visual evoked potential of the squirrel monkey fed hexachlorophene. Tox. Appl. Pharmacol. 22(2): 276 (1972). 24 Santolucito, J. A.: Personal communication. 25 Hale, G. A., and Reid, J. M.: Hexachlorophene toxicity in sheep. Lancet 2: 1251 (1972). 26 Magee, P. N., Stoner, H. B., and Barnes, J. M.: The experimental production of oedema in the central nervous system of the rat by triethyltin compounds. J. Path. Bact. 73: 107 (1957). 27 Adornato, B., and Lampert, P.: Status spongiosus of nervous tissue. Acta Neuropath. 19: 271 (1971). 28 Kurtz, S. M., Schardein, J. L., Fitzgerald, J. E., and Kaump, D. H.: Toxicologic studies with a halogenated salicylanilide. Tox. Appl. Pharmacol. 14: 81 (1969). 29 Curley, A., Hawk, R. E. Kimbrough, R. D., Natenson, G. and Finberg, L.: Dermal absorption of hexachlorophene in infants: Lancet 2: 296 (1971). 30 Ulsamer, A. G., Yoder, P. D., and Marzulli, F. N.: Determination of hexachlorophene in human and experimental animal tissue. Tox. Appl. Pharmacol. 22(2): 276, (1972). 31 Sedlak, V.(EPA, 4770 Buford Highway, Chamblee, Ga. 30341), and Kopelman, A. E. (University of Rochester, Rochester, N.Y.): Personal communications. 32 Ulsamer, A. G.: The determination of hexachlorophene in mammalian tissues by gas-liquid chromatography. J.A.O.A.C. 55: 1294 (1972). 33 Zehr, R. D.. (EPA, 4770 Buford Highway, Chamblee, Ga. 30341). Personal communication. 34 Caldwell, R. S., Nakaue, H. D., and Buhler, D. R.: Biochemical lesion in rat liver mitochondria induced by hexachlorophene. Biochem. Pharmacol. 21: 2425 (1972). 35 Cammer, W., and Moore, C. L.: The effect of hexachlorophene on the respiration of brain and liver mitochondria. Biochem. Biophys. Res. Communications 46: 1887 (1972). Citing Literature Volume13, Issue11November‐December 1973Pages 439-444 ReferencesRelatedInformation" @default.
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