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- W2162680148 abstract "The mitosis-to-endocycle transition requires the controlled inactivation of M phase-associated cyclin-dependent kinase (CDK) activity. Previously, the B-type CDKB1;1 was identified as an important negative regulator of endocycle onset. Here, we demonstrate that CDKB1;1 copurifies and associates with the A2-type cyclin CYCA2;3. Coexpression of CYCA2;3 with CDKB1;1 triggered ectopic cell divisions and inhibited endoreduplication. Moreover, the enhanced endoreduplication phenotype observed after overexpression of a dominant-negative allele of CDKB1;1 could be partially complemented by CYCA2;3 co-overexpression, illustrating that both subunits unite in vivo to form a functional complex. CYCA2;3 protein stability was found to be controlled by CCS52A1, an activator of the anaphase-promoting complex. We conclude that CCS52A1 participates in endocycle onset by down-regulating CDKB1;1 activity through the destruction of CYCA2;3." @default.
- W2162680148 created "2016-06-24" @default.
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- W2162680148 date "2009-05-20" @default.
- W2162680148 modified "2023-10-13" @default.
- W2162680148 title "CDKB1;1 Forms a Functional Complex with CYCA2;3 to Suppress Endocycle Onset " @default.
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- W2162680148 doi "https://doi.org/10.1104/pp.109.140269" @default.
- W2162680148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2705057" @default.
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