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• W2162706450 abstract "Capacitative Ca²⁺ entry (CCE) in vascular smooth muscle cells contributes to vasoconstrictor and mitogenic effects of vasoactive hormones. In A7r5 rat aortic smooth muscle cells, measurements of cytosolic free Ca²⁺ concentration ([Ca²⁺]_i) have demonstrated that depletion of intracellular Ca²⁺ stores activates CCE. However, there is disagreement in published studies regarding the regulation of this mechanism by the vasoconstrictor hormone [Arg⁸]-vasopressin (AVP). We have employed electrophysiological methods to characterize the membrane currents activated by store depletion [store-operated current (I_SOC)]. Because of different recording conditions, it has not been previously determined whether I_SOC corresponds to CCE measured using fura-2; nor has the channel protein responsible for CCE been identified. In the present study, the pharmacological characteristics of I_SOC, including its sensitivity to blockade by 2-aminoethoxydiphenylborane, diethylstilbestrol, or micromolar Gd³⁺, were found to parallel the effects of these drugs on thapsigargin- or AVP-activated CCE measured under identical external ionic conditions using fura-2. Thapsigargin-stimulated I_SOC was also measured in freshly isolated rat mesenteric artery smooth muscle cells (MASMC). Members of the transient receptor potential (TRP) family of nonselective cation channels, TRPC1, TRPC4, and TRPC6, were detected by reverse transcription-polymerase chain reaction and Western blot in both A7r5 cells and MASMC. TRPC1 expression was reduced in a stable A7r5 cell line expressing a small interfering RNA (siRNA) or by infection of A7r5 cells with an adenovirus expressing a TRPC1 antisense nucleotide sequence. Thapsigargin-stimulated I_SOC was reduced in both the TRPC1 siRNA- and TRPC1 antisense-expressing cells, suggesting that the TRPC1 channel contributes to the I_SOC/CCE pathway." @default.
• W2162706450 created "2016-06-24" @default.
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• W2162706450 date "2006-01-13" @default.
• W2162706450 modified "2023-10-17" @default.
• W2162706450 title "Pharmacological and Electrophysiological Characterization of Store-Operated Currents and Capacitative Ca²⁺Entry in Vascular Smooth Muscle Cells" @default.
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• W2162706450 doi "https://doi.org/10.1124/jpet.105.095067" @default.
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