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• W2162756888 startingPage "62" @default.
• W2162756888 abstract "The concept of 'field cancerization' describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones. We quantitatively analyze how the activation of oncogenic K-ras in individual Lgr5(+) stem cells accelerates their cell division rate and creates a biased drift towards crypt clonality. K-ras mutant crypts then clonally expand within the epithelium through enhanced crypt fission, which distributes the existing Paneth cell niche over the two new crypts. Thus, an unequal competition between wild-type and mutant intestinal stem cells initiates a biased drift that leads to the clonal expansion of crypts carrying oncogenic mutations." @default.
• W2162756888 created "2016-06-24" @default.
• W2162756888 creator A5012566985 @default.
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• W2162756888 creator A5081582414 @default.
• W2162756888 date "2013-12-16" @default.
• W2162756888 modified "2023-10-14" @default.
• W2162756888 title "Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion" @default.
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• W2162756888 doi "https://doi.org/10.1002/embr.201337799" @default.
• W2162756888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3983678" @default.
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• W2162756888 hasPublicationYear "2013" @default.
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