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• W2162783248 abstract "ABSTRACT Neurological manifestations of Lyme disease are usually accompanied by inflammatory changes in the cerebrospinal fluid (CSF) and the recruitment of activated T cells into the CSF compartment. In order to characterize the phenotype and identify target antigens of CSF-infiltrating T cells in early neuroborreliosis with central nervous system (CNS) involvement, we combined T-cell cloning, functional testing of T-cell responses with positional scanning synthetic combinatorial peptide libraries, and biometric data analysis. We demonstrate that CD4 + gamma interferon-producing T cells specifically responding to Borrelia burgdorferi lysate were present in the CSF of a patient with acute Lyme encephalitis. Some T-cell clones recognized previously uncharacterized B. burgdorferi epitopes which show a specific enrichment for lysine, such as the heat shock-induced chaperone HSP90. Degenerate T-cell recognition that included T-cell responses to borrelia-specific and CNS-specific autoantigens derived from the myelin protein 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase) could be demonstrated for one representative clone. Our results show that spirochetal antigen-specific and Th1-polarized CD4 + lymphocytes infiltrate the CSF during monophasic CNS symptoms of Lyme disease and demonstrate that cross-recognition of CNS antigens by B. burgdorferi -specific T cells is not restricted to chronic and treatment-resistant manifestations." @default.
• W2162783248 created "2016-06-24" @default.
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• W2162783248 date "2007-01-01" @default.
• W2162783248 modified "2023-09-30" @default.
• W2162783248 title "Cerebrospinal Fluid-Infiltrating CD4⁺T Cells Recognize<i>Borrelia burgdorferi</i>Lysine-Enriched Protein Domains and Central Nervous System Autoantigens in Early Lyme Encephalitis" @default.
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• W2162783248 doi "https://doi.org/10.1128/iai.01110-06" @default.
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