Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162813596> ?p ?o ?g. }
- W2162813596 endingPage "304" @default.
- W2162813596 startingPage "295" @default.
- W2162813596 abstract "Environmental exposure is a complex mixture of hazardous compounds with different mechanisms of toxicity. In case of concomitant exposure to carcinogenic substances—such as polycyclic aromatic hydrocarbons (PAHs)—and to heavy metals—such as lead (Pb)—the level of DNA damage may be enhanced. Children are considered more vulnerable than adults to chemical toxicants because they take in more toxicants as a proportion of body mass and because of inherent biological growth and developmental factors. The objective of the study was to measure cytogenetic effects in Silesian children and to investigate their relation with the environmental exposure to PAHs and Pb. The examined population included 74 children 5–14-year-old who lived in two cities located in the most polluted centre of the Silesia province. Individual exposure to lead was assessed for each child by measuring lead in blood (PbB), and to PAH by measuring 1-hydroxypyrene in urine (1-OHP), urinary mutagenicity and DNA adducts in circulating lymphocytes. Biomarkers of genetic effects were assessed by measuring micronuclei (MN) and sister chromatid exchanges (SCE) in children's peripheral lymphocytes. The mean levels of biomarkers of exposure were as follows: PbB 7.69 μg/dl, DNA adducts 9.59 adducts per 108 nt, 1-OHP 0.54 μmol/mol creatinine, and urinary mutagenicity presented as the number of revertants per mmol of creatinine: 485 for TA 98 and 1318 for YG1024. Mean value of MN was 4.44 per 1000 binucleated cells and SCE frequency ranged between 6.24 and 10.06 with a mean value of 7.87. The results suggest the influence of exposure to environmental agents on the induction of cytogenetic effects in peripheral lymphocytes of children: namely Pb on MN and PAHs on SCE. The sources of that exposure may be outdoor and indoor. Emissions from coal-burning stoves are important contributors to the total exposure to PAHs and Pb in Silesian children." @default.
- W2162813596 created "2016-06-24" @default.
- W2162813596 creator A5001990059 @default.
- W2162813596 creator A5020137513 @default.
- W2162813596 creator A5064324643 @default.
- W2162813596 creator A5066549924 @default.
- W2162813596 creator A5066606583 @default.
- W2162813596 creator A5005303212 @default.
- W2162813596 date "2006-09-01" @default.
- W2162813596 modified "2023-10-18" @default.
- W2162813596 title "The influence of environmental exposure to complex mixtures including PAHs and lead on genotoxic effects in children living in Upper Silesia, Poland" @default.
- W2162813596 cites W1485958388 @default.
- W2162813596 cites W1516698175 @default.
- W2162813596 cites W1527816314 @default.
- W2162813596 cites W1537167794 @default.
- W2162813596 cites W1557669107 @default.
- W2162813596 cites W1963535998 @default.
- W2162813596 cites W1963562708 @default.
- W2162813596 cites W1963618586 @default.
- W2162813596 cites W1966599934 @default.
- W2162813596 cites W1968102082 @default.
- W2162813596 cites W1969248852 @default.
- W2162813596 cites W1971931322 @default.
- W2162813596 cites W1973195696 @default.
- W2162813596 cites W1979661461 @default.
- W2162813596 cites W1983785443 @default.
- W2162813596 cites W1983942753 @default.
- W2162813596 cites W1986347122 @default.
- W2162813596 cites W1986487308 @default.
- W2162813596 cites W1989279992 @default.
- W2162813596 cites W1994700344 @default.
- W2162813596 cites W1995277333 @default.
- W2162813596 cites W2000378974 @default.
- W2162813596 cites W2003132377 @default.
- W2162813596 cites W2007405301 @default.
- W2162813596 cites W2011345676 @default.
- W2162813596 cites W2016091779 @default.
- W2162813596 cites W2017471137 @default.
- W2162813596 cites W2022431809 @default.
- W2162813596 cites W2022733561 @default.
- W2162813596 cites W2028505476 @default.
- W2162813596 cites W2032637777 @default.
- W2162813596 cites W2035241423 @default.
- W2162813596 cites W2035449472 @default.
- W2162813596 cites W2038744267 @default.
- W2162813596 cites W2038959965 @default.
- W2162813596 cites W2041827849 @default.
- W2162813596 cites W2043554484 @default.
- W2162813596 cites W2051305531 @default.
- W2162813596 cites W2052541400 @default.
- W2162813596 cites W2057232640 @default.
- W2162813596 cites W2061324292 @default.
- W2162813596 cites W2066443362 @default.
- W2162813596 cites W2067202982 @default.
- W2162813596 cites W2071888784 @default.
- W2162813596 cites W2078696473 @default.
- W2162813596 cites W2079214545 @default.
- W2162813596 cites W2079931352 @default.
- W2162813596 cites W2095619460 @default.
- W2162813596 cites W2096813878 @default.
- W2162813596 cites W2101614006 @default.
- W2162813596 cites W2102801402 @default.
- W2162813596 cites W2105770609 @default.
- W2162813596 cites W2125158091 @default.
- W2162813596 cites W2137482487 @default.
- W2162813596 cites W2149470488 @default.
- W2162813596 cites W2153942884 @default.
- W2162813596 cites W2162750821 @default.
- W2162813596 cites W2164803346 @default.
- W2162813596 cites W2167577310 @default.
- W2162813596 cites W2171981449 @default.
- W2162813596 cites W2257318971 @default.
- W2162813596 cites W2402851790 @default.
- W2162813596 cites W2405974462 @default.
- W2162813596 cites W2409899402 @default.
- W2162813596 cites W2410284155 @default.
- W2162813596 cites W2415796760 @default.
- W2162813596 cites W2416081806 @default.
- W2162813596 cites W2419110748 @default.
- W2162813596 cites W2428394707 @default.
- W2162813596 cites W2572860910 @default.
- W2162813596 cites W3186121553 @default.
- W2162813596 doi "https://doi.org/10.1093/mutage/gel037" @default.
- W2162813596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16891332" @default.
- W2162813596 hasPublicationYear "2006" @default.
- W2162813596 type Work @default.
- W2162813596 sameAs 2162813596 @default.
- W2162813596 citedByCount "48" @default.
- W2162813596 countsByYear W21628135962012 @default.
- W2162813596 countsByYear W21628135962013 @default.
- W2162813596 countsByYear W21628135962014 @default.
- W2162813596 countsByYear W21628135962015 @default.
- W2162813596 countsByYear W21628135962016 @default.
- W2162813596 countsByYear W21628135962017 @default.
- W2162813596 countsByYear W21628135962018 @default.
- W2162813596 countsByYear W21628135962019 @default.
- W2162813596 countsByYear W21628135962020 @default.
- W2162813596 countsByYear W21628135962022 @default.