FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162817186> ?p ?o ?g. }

• W2162817186 endingPage "633" @default.
• W2162817186 startingPage "625" @default.
• W2162817186 abstract "Lipopolysaccharide (LPS) is known to generate nitric oxide (NO) in the airway through the activation of nitric-oxide synthase (NOS). The functional consequences of this on the inflammatory response are not clear, with conflicting data published. In the clinic, exhaled NO (ex-NO) is used as a noninvasive biomarker to assess the extent of airway inflammation. It is proposed that monitoring levels of ex-NO could be a useful guide to determining the effectiveness of disease modifying therapies. The aim was, using pharmacological tools, to determine the role of NO in an aerosolized LPS-driven animal model of airway inflammation by assessment of ex-NO, neutrophilia, and inflammatory biomarkers, using a nonselective NOS inhibitor, <i>N</i>^G-nitro-l-arginine methyl ester (l-NAME), and a selective inducible NOS (iNOS) inhibitor, <i>N</i>-3 (aminomethyl)benzyl)acetamidine (1400W). Real-time mRNA analysis of the lung tissue indicated an increased gene expression of iNOS following LPS challenge with minimal impact on constitutive NOS isoforms. LPS induced an increase in ex-NO, which appeared to correlate with the increase in iNOS gene expression and airway neutrophilia. Treatment with l-NAME and 1400W resulted in comparable reductions in ex-NO, a reduction in airway neutrophilia, but had little impact on a range of inflammatory biomarkers. This study indicates that the LPS-induced rise in ex-NO is due to enhanced iNOS activity and that NO has a role in airway neutrophilia. Additionally, it appears using ex-NO as a guide to monitoring airway inflammation may have some use, but data should be interpreted with caution when assessing therapies that may directly impact on NO formation." @default.
• W2162817186 created "2016-06-24" @default.
• W2162817186 creator A5006299446 @default.
• W2162817186 creator A5056802642 @default.
• W2162817186 creator A5060255080 @default.
• W2162817186 creator A5090651281 @default.
• W2162817186 date "2004-06-29" @default.
• W2162817186 modified "2023-09-27" @default.
• W2162817186 title "Nitric Oxide as a Noninvasive Biomarker of Lipopolysaccharide-Induced Airway Inflammation: Possible Role in Lung Neutrophilia" @default.
• W2162817186 cites W1970249744 @default.
• W2162817186 cites W1970607492 @default.
• W2162817186 cites W1974726443 @default.
• W2162817186 cites W1975308859 @default.
• W2162817186 cites W1980481020 @default.
• W2162817186 cites W1988538366 @default.
• W2162817186 cites W1998405659 @default.
• W2162817186 cites W2000835895 @default.
• W2162817186 cites W2004157751 @default.
• W2162817186 cites W2005466083 @default.
• W2162817186 cites W2011347602 @default.
• W2162817186 cites W2014592293 @default.
• W2162817186 cites W2026301106 @default.
• W2162817186 cites W2040428153 @default.
• W2162817186 cites W2052391094 @default.
• W2162817186 cites W2054891377 @default.
• W2162817186 cites W2058581019 @default.
• W2162817186 cites W2071726038 @default.
• W2162817186 cites W2072304029 @default.
• W2162817186 cites W2080138855 @default.
• W2162817186 cites W2118571380 @default.
• W2162817186 cites W2143778995 @default.
• W2162817186 cites W2144633516 @default.
• W2162817186 cites W2171579796 @default.
• W2162817186 cites W2419583647 @default.
• W2162817186 doi "https://doi.org/10.1124/jpet.104.068890" @default.
• W2162817186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15226380" @default.
• W2162817186 hasPublicationYear "2004" @default.
• W2162817186 type Work @default.
• W2162817186 sameAs 2162817186 @default.
• W2162817186 citedByCount "34" @default.
• W2162817186 countsByYear W21628171862012 @default.
• W2162817186 countsByYear W21628171862013 @default.
• W2162817186 countsByYear W21628171862015 @default.
• W2162817186 countsByYear W21628171862016 @default.
• W2162817186 countsByYear W21628171862018 @default.
• W2162817186 countsByYear W21628171862019 @default.
• W2162817186 countsByYear W21628171862020 @default.
• W2162817186 countsByYear W21628171862021 @default.
• W2162817186 crossrefType "journal-article" @default.
• W2162817186 hasAuthorship W2162817186A5006299446 @default.
• W2162817186 hasAuthorship W2162817186A5056802642 @default.
• W2162817186 hasAuthorship W2162817186A5060255080 @default.
• W2162817186 hasAuthorship W2162817186A5090651281 @default.
• W2162817186 hasConcept C105922876 @default.
• W2162817186 hasConcept C126322002 @default.
• W2162817186 hasConcept C185592680 @default.
• W2162817186 hasConcept C202751555 @default.
• W2162817186 hasConcept C203014093 @default.
• W2162817186 hasConcept C26291073 @default.
• W2162817186 hasConcept C2776252253 @default.
• W2162817186 hasConcept C2776914184 @default.
• W2162817186 hasConcept C2777622882 @default.
• W2162817186 hasConcept C2777714996 @default.
• W2162817186 hasConcept C2777802486 @default.
• W2162817186 hasConcept C2778754761 @default.
• W2162817186 hasConcept C2781142857 @default.
• W2162817186 hasConcept C2781197716 @default.
• W2162817186 hasConcept C42219234 @default.
• W2162817186 hasConcept C519581460 @default.
• W2162817186 hasConcept C55493867 @default.
• W2162817186 hasConcept C71924100 @default.
• W2162817186 hasConcept C98274493 @default.
• W2162817186 hasConceptScore W2162817186C105922876 @default.
• W2162817186 hasConceptScore W2162817186C126322002 @default.
• W2162817186 hasConceptScore W2162817186C185592680 @default.
• W2162817186 hasConceptScore W2162817186C202751555 @default.
• W2162817186 hasConceptScore W2162817186C203014093 @default.
• W2162817186 hasConceptScore W2162817186C26291073 @default.
• W2162817186 hasConceptScore W2162817186C2776252253 @default.
• W2162817186 hasConceptScore W2162817186C2776914184 @default.
• W2162817186 hasConceptScore W2162817186C2777622882 @default.
• W2162817186 hasConceptScore W2162817186C2777714996 @default.
• W2162817186 hasConceptScore W2162817186C2777802486 @default.
• W2162817186 hasConceptScore W2162817186C2778754761 @default.
• W2162817186 hasConceptScore W2162817186C2781142857 @default.
• W2162817186 hasConceptScore W2162817186C2781197716 @default.
• W2162817186 hasConceptScore W2162817186C42219234 @default.
• W2162817186 hasConceptScore W2162817186C519581460 @default.
• W2162817186 hasConceptScore W2162817186C55493867 @default.
• W2162817186 hasConceptScore W2162817186C71924100 @default.
• W2162817186 hasConceptScore W2162817186C98274493 @default.
• W2162817186 hasIssue "2" @default.
• W2162817186 hasLocation W21628171861 @default.
• W2162817186 hasLocation W21628171862 @default.
• W2162817186 hasOpenAccess W2162817186 @default.
• W2162817186 hasPrimaryLocation W21628171861 @default.
• W2162817186 hasRelatedWork W108093282 @default.
• W2162817186 hasRelatedWork W1968811274 @default.

• next