Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162839906> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2162839906 endingPage "933" @default.
- W2162839906 startingPage "927" @default.
- W2162839906 abstract "To study an expected transition of misoprostol from human blood into breast milk, a novel method for the determination of its active metabolite misoprostol acid (MPA) was developed. MPA was determined in serum and breast milk samples by an isotope dilution assay using gas chromatography/negative ion chemical ionization tandem mass spectrometry (GC/NICI-MS/MS). After addition of (15S)-15-methylprostaglandin E(2) (15-methyl-PGE(2)) as an internal standard, MPA was extracted from both matrices using a reversed-phase cartridge. The prostanoids were derivatized with O-2,3,4,5,6-pentafluorobenzylhydroxylamine hydrochloride (PFBHA) and 2,3,4,5,6-pentafluorobenzyl bromide (PFBB) to the pentafluorobenzyl oxime (PFBO)-pentafluorobenzyl ester (PFB) derivatives. The sample was subjected to thin-layer chromatography with ethyl acetate-hexane (1 : 1 (v/v)) as the developing solvent. The corresponding zone was extracted. After derivatization to the trimethylsilyl ether, MPA was determined by GC/NICI-MS/MS using the [molecule (M) - pentafluorobenzyl (PFB)](-) ([P](-)) ions as precursor in the negative ion chemical ionization mode. The product ions used for quantification were [P - 2TMSOH - C(6)F(5)CH(2)OH](-) (MPA) and [P - 2TMSOH - C(6)F(5)CH(2)OH - CO(2)](-)(15-methyl-PGE(2)), respectively. The limit of quantification for MPA was approximately 1 pg ml(-1) in breast milk and serum samples. The correlation coefficients of the calibration curves for MPA were r > 0.997 in the 0.5-2000 pg ml(-1) range for both tested matrices." @default.
- W2162839906 created "2016-06-24" @default.
- W2162839906 creator A5018853137 @default.
- W2162839906 creator A5019224497 @default.
- W2162839906 creator A5091712002 @default.
- W2162839906 date "2002-07-24" @default.
- W2162839906 modified "2023-10-11" @default.
- W2162839906 title "Determination of misoprostol free acid in human breast milk and serum by gas chromatography/negative ion chemical ionization tandem mass spectrometry" @default.
- W2162839906 cites W1986264727 @default.
- W2162839906 cites W2001033419 @default.
- W2162839906 cites W2012247421 @default.
- W2162839906 cites W2024236979 @default.
- W2162839906 cites W2027523966 @default.
- W2162839906 cites W2030324873 @default.
- W2162839906 cites W2049728749 @default.
- W2162839906 cites W2050379703 @default.
- W2162839906 cites W2052243820 @default.
- W2162839906 cites W2056501353 @default.
- W2162839906 cites W2085063455 @default.
- W2162839906 cites W2087256679 @default.
- W2162839906 cites W2115139125 @default.
- W2162839906 cites W2410986427 @default.
- W2162839906 cites W4246074027 @default.
- W2162839906 doi "https://doi.org/10.1002/jms.351" @default.
- W2162839906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12271435" @default.
- W2162839906 hasPublicationYear "2002" @default.
- W2162839906 type Work @default.
- W2162839906 sameAs 2162839906 @default.
- W2162839906 citedByCount "24" @default.
- W2162839906 countsByYear W21628399062012 @default.
- W2162839906 countsByYear W21628399062014 @default.
- W2162839906 countsByYear W21628399062015 @default.
- W2162839906 countsByYear W21628399062016 @default.
- W2162839906 countsByYear W21628399062022 @default.
- W2162839906 crossrefType "journal-article" @default.
- W2162839906 hasAuthorship W2162839906A5018853137 @default.
- W2162839906 hasAuthorship W2162839906A5019224497 @default.
- W2162839906 hasAuthorship W2162839906A5091712002 @default.
- W2162839906 hasConcept C119128265 @default.
- W2162839906 hasConcept C123460561 @default.
- W2162839906 hasConcept C145148216 @default.
- W2162839906 hasConcept C162356407 @default.
- W2162839906 hasConcept C178790620 @default.
- W2162839906 hasConcept C185592680 @default.
- W2162839906 hasConcept C198291218 @default.
- W2162839906 hasConcept C205345274 @default.
- W2162839906 hasConcept C2776923573 @default.
- W2162839906 hasConcept C2909038973 @default.
- W2162839906 hasConcept C43617362 @default.
- W2162839906 hasConcept C51884965 @default.
- W2162839906 hasConceptScore W2162839906C119128265 @default.
- W2162839906 hasConceptScore W2162839906C123460561 @default.
- W2162839906 hasConceptScore W2162839906C145148216 @default.
- W2162839906 hasConceptScore W2162839906C162356407 @default.
- W2162839906 hasConceptScore W2162839906C178790620 @default.
- W2162839906 hasConceptScore W2162839906C185592680 @default.
- W2162839906 hasConceptScore W2162839906C198291218 @default.
- W2162839906 hasConceptScore W2162839906C205345274 @default.
- W2162839906 hasConceptScore W2162839906C2776923573 @default.
- W2162839906 hasConceptScore W2162839906C2909038973 @default.
- W2162839906 hasConceptScore W2162839906C43617362 @default.
- W2162839906 hasConceptScore W2162839906C51884965 @default.
- W2162839906 hasIssue "9" @default.
- W2162839906 hasLocation W21628399061 @default.
- W2162839906 hasLocation W21628399062 @default.
- W2162839906 hasOpenAccess W2162839906 @default.
- W2162839906 hasPrimaryLocation W21628399061 @default.
- W2162839906 hasRelatedWork W1850236418 @default.
- W2162839906 hasRelatedWork W1994350484 @default.
- W2162839906 hasRelatedWork W2033401628 @default.
- W2162839906 hasRelatedWork W2057766918 @default.
- W2162839906 hasRelatedWork W2128166594 @default.
- W2162839906 hasRelatedWork W219495507 @default.
- W2162839906 hasRelatedWork W2315299911 @default.
- W2162839906 hasRelatedWork W2809650275 @default.
- W2162839906 hasRelatedWork W2978102718 @default.
- W2162839906 hasRelatedWork W2997529584 @default.
- W2162839906 hasVolume "37" @default.
- W2162839906 isParatext "false" @default.
- W2162839906 isRetracted "false" @default.
- W2162839906 magId "2162839906" @default.
- W2162839906 workType "article" @default.