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- W2162855885 endingPage "15639" @default.
- W2162855885 startingPage "15601" @default.
- W2162855885 abstract "Flavoprotein monooxygenases (FPMOs) exhibit an array of mechanistic solutions to a common chemical objective; the monooxygenation of a target substrate. Each FPMO efficiently couples reduction of a flavin cofactor by NAD(P)H to oxygenation of the target substrate via a (hydro)peroxyflavin intermediate. This purpose of this review is to describe in detail the Class A flavoprotein hydroxylases (FPMO) in the context of the other FPMO classes (B-F). Both one and two component FPMOs are found in nature. Two-component enzymes require, in addition to the monooxygenase, the involvement of a reductase that first catalyzes the reduction of the flavin by NAD(P)H. The Class A and B FPMOs are single-component and manage to orchestrate the same net reaction within a single peptide. The Class A enzymes have, by some considerable margin, the most complete research record. These enzymes use choreographed movements of the flavin ring that facilitate access of the organic substrates to the active site, provide a means for interaction of NADPH with the flavin, offer a mechanism to sequester the dioxygen reduction chemistry from solvent and a means to release the product. The majority of the discrete catalytic events of the catalytic cycle can be observed directly in exquisite detail using spectrophotometric kinetic methods and many of the key mechanistic conclusions are further supported by structural data. This review attempts to compile each of the key observations made for both paradigm and newly discovered examples of Class A FPMOs into a complete catalytic description of one enzymatic turnover." @default.
- W2162855885 created "2016-06-24" @default.
- W2162855885 creator A5022477335 @default.
- W2162855885 creator A5025588316 @default.
- W2162855885 date "2012-11-23" @default.
- W2162855885 modified "2023-10-01" @default.
- W2162855885 title "Form Follows Function: Structural and Catalytic Variation in the Class A Flavoprotein Monooxygenases" @default.
- W2162855885 cites W1485336678 @default.
- W2162855885 cites W1490507349 @default.
- W2162855885 cites W1498056064 @default.
- W2162855885 cites W1503005373 @default.
- W2162855885 cites W1507826611 @default.
- W2162855885 cites W1514812733 @default.
- W2162855885 cites W1534619350 @default.
- W2162855885 cites W1538529173 @default.
- W2162855885 cites W1552939162 @default.
- W2162855885 cites W1554198147 @default.
- W2162855885 cites W1557718367 @default.
- W2162855885 cites W1564858254 @default.
- W2162855885 cites W1576778788 @default.
- W2162855885 cites W1578361926 @default.
- W2162855885 cites W1579858516 @default.
- W2162855885 cites W1598067475 @default.
- W2162855885 cites W1605583295 @default.
- W2162855885 cites W1619230477 @default.
- W2162855885 cites W165068004 @default.
- W2162855885 cites W1848681546 @default.
- W2162855885 cites W1849264732 @default.
- W2162855885 cites W1876994579 @default.
- W2162855885 cites W1911022049 @default.
- W2162855885 cites W1964090447 @default.
- W2162855885 cites W1964976226 @default.
- W2162855885 cites W1973009377 @default.
- W2162855885 cites W1973816625 @default.
- W2162855885 cites W1975349287 @default.
- W2162855885 cites W1978775660 @default.
- W2162855885 cites W1981825657 @default.
- W2162855885 cites W1986562514 @default.
- W2162855885 cites W1989595915 @default.
- W2162855885 cites W1989709860 @default.
- W2162855885 cites W1997968457 @default.
- W2162855885 cites W1998335176 @default.
- W2162855885 cites W1999623718 @default.
- W2162855885 cites W2002372650 @default.
- W2162855885 cites W2006890845 @default.
- W2162855885 cites W2007675461 @default.
- W2162855885 cites W2008347404 @default.
- W2162855885 cites W2009688026 @default.
- W2162855885 cites W2009777271 @default.
- W2162855885 cites W2012931522 @default.
- W2162855885 cites W2014918380 @default.
- W2162855885 cites W2015220144 @default.
- W2162855885 cites W2015583027 @default.
- W2162855885 cites W2023400863 @default.
- W2162855885 cites W2024973460 @default.
- W2162855885 cites W2025006941 @default.
- W2162855885 cites W2026729349 @default.
- W2162855885 cites W2029157226 @default.
- W2162855885 cites W2029545844 @default.
- W2162855885 cites W2033330355 @default.
- W2162855885 cites W2034974282 @default.
- W2162855885 cites W2035494815 @default.
- W2162855885 cites W2035971017 @default.
- W2162855885 cites W2038227178 @default.
- W2162855885 cites W2040566687 @default.
- W2162855885 cites W2041099094 @default.
- W2162855885 cites W2041411283 @default.
- W2162855885 cites W2041610864 @default.
- W2162855885 cites W2042850764 @default.
- W2162855885 cites W2043259874 @default.
- W2162855885 cites W2044416309 @default.
- W2162855885 cites W2045815590 @default.
- W2162855885 cites W2046293398 @default.
- W2162855885 cites W2047769236 @default.
- W2162855885 cites W2049596952 @default.
- W2162855885 cites W2053417073 @default.
- W2162855885 cites W2053767748 @default.
- W2162855885 cites W2054943036 @default.
- W2162855885 cites W2055609118 @default.
- W2162855885 cites W2057232866 @default.
- W2162855885 cites W2057318904 @default.
- W2162855885 cites W2058266521 @default.
- W2162855885 cites W2059321502 @default.
- W2162855885 cites W2062261415 @default.
- W2162855885 cites W2067560083 @default.
- W2162855885 cites W2070748794 @default.
- W2162855885 cites W2072828517 @default.
- W2162855885 cites W2073633458 @default.
- W2162855885 cites W2073806282 @default.
- W2162855885 cites W2075024984 @default.
- W2162855885 cites W2075295290 @default.
- W2162855885 cites W2080648134 @default.
- W2162855885 cites W2082234702 @default.
- W2162855885 cites W2083533827 @default.
- W2162855885 cites W2084352362 @default.
- W2162855885 cites W2085896180 @default.
- W2162855885 cites W2088404403 @default.
- W2162855885 cites W2091631120 @default.