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• W2162859266 abstract "<h3>Abstract</h3> <b>Objective</b> To evaluate whether routine administration of sublingual misoprostol 600 μg after delivery reduces postpartum haemorrhage. <b>Design</b> Randomised double blind placebo controlled trial. <b>Setting</b> Primary health centre in Bissau, Guinea-Bissau, West Africa. <b>Participants</b> 661 women undergoing vaginal delivery. <b>Intervention</b> Misoprostol 600 μg or placebo administered sublingually immediately after delivery. <b>Main outcome measures</b> Postpartum haemorrhage, defined as a loss of ≥ 500 ml and decrease in haemoglobin concentration after delivery. <b>Results</b> The incidence of postpartum haemorrhage was not significantly different between the two groups, the relative risk being 0.89 (95% confidence interval 0.76 to 1.04) in the misoprostol group compared with the placebo group. Mean blood loss was 10.5% (−0.5% to 20.4%) lower in the misoprostol group than in the control group. Severe postpartum haemorrhage of ≥ 1000 ml or ≥1500 ml occurred in 17% (56) and 8% (25) in the placebo group and 11% (37) and 2% (7) in the misoprostol group. Significantly fewer women in the misoprostol group experienced a loss of ≥1000 ml (0.66, 0.45 to 0.98) or ≥ 1500 ml (0.28, 0.12 to 0.64). The decrease in haemoglobin concentration tended to be less in the misoprostol group, the mean difference between the two groups being 0.16 mmol/l (−0.01 mmol/l to 0.32 mmol/l). <b>Conclusion</b> Sublingual misoprostol reduces the frequency of severe postpartum haemorrhage." @default.
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• W2162859266 date "2005-09-29" @default.
• W2162859266 modified "2023-10-03" @default.
• W2162859266 title "Effect of sublingual misoprostol on severe postpartum haemorrhage in a primary health centre in Guinea-Bissau: randomised double blind clinical trial" @default.
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• W2162859266 doi "https://doi.org/10.1136/bmj.331.7519.723" @default.
• W2162859266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1239973" @default.
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