FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162880997> ?p ?o ?g. }

• W2162880997 endingPage "8897" @default.
• W2162880997 startingPage "8889" @default.
• W2162880997 abstract "In addition to its potent effects on vasculature, it has become clear that vascular endothelial growth factor (VEGF) has effects on both neurons and glia, and recent studies suggest that it can be neuroprotective. To determine potential mechanisms underlying this neuroprotection, recombinant human VEGF was bath applied to adult rat hippocampal slices, and both extracellular and intracellular recordings were used to examine intrinsic properties and synaptic responses of hippocampal principal neurons. Initial studies in area CA1 showed that VEGF significantly reduced the amplitude of responses elicited by Schaffer collateral stimulation, without influencing membrane properties. Similar effects occurred in CA3 pyramidal cells and dentate gyrus granule cells when their major glutamatergic afferents were stimulated. Because VEGF expression is increased after seizures, effects of VEGF were also examined in rats with recurrent spontaneous seizures. VEGF reduced spontaneous discharges in slices from these rats but had surprisingly little effect on epileptiform discharges produced by disinhibition of slices from control rats. These results demonstrate a previously unknown effect of VEGF on neuronal activity and also demonstrate a remarkable potency in the epileptic brain. Based on this, we suggest that VEGF or VEGF-related targets could provide useful endpoints to direct novel therapeutic strategies for epilepsy." @default.
• W2162880997 created "2016-06-24" @default.
• W2162880997 creator A5013260521 @default.
• W2162880997 creator A5070887960 @default.
• W2162880997 creator A5073000103 @default.
• W2162880997 date "2005-09-28" @default.
• W2162880997 modified "2023-10-17" @default.
• W2162880997 title "Depression of Synaptic Transmission by Vascular Endothelial Growth Factor in Adult Rat Hippocampus and Evidence for Increased Efficacy after Chronic Seizures" @default.
• W2162880997 cites W1524233205 @default.
• W2162880997 cites W1647455825 @default.
• W2162880997 cites W174912705 @default.
• W2162880997 cites W1783580437 @default.
• W2162880997 cites W1883162734 @default.
• W2162880997 cites W189480869 @default.
• W2162880997 cites W1972580551 @default.
• W2162880997 cites W1972875007 @default.
• W2162880997 cites W1983297228 @default.
• W2162880997 cites W1987278634 @default.
• W2162880997 cites W1987522740 @default.
• W2162880997 cites W1987804149 @default.
• W2162880997 cites W1991148019 @default.
• W2162880997 cites W1997059788 @default.
• W2162880997 cites W1998173762 @default.
• W2162880997 cites W1998880668 @default.
• W2162880997 cites W2001612609 @default.
• W2162880997 cites W2003982930 @default.
• W2162880997 cites W2006471079 @default.
• W2162880997 cites W2014386715 @default.
• W2162880997 cites W2021842070 @default.
• W2162880997 cites W2025868911 @default.
• W2162880997 cites W2028069038 @default.
• W2162880997 cites W2038917001 @default.
• W2162880997 cites W2043732175 @default.
• W2162880997 cites W2045336331 @default.
• W2162880997 cites W2053068006 @default.
• W2162880997 cites W2053272214 @default.
• W2162880997 cites W2053483719 @default.
• W2162880997 cites W2061356996 @default.
• W2162880997 cites W2062704746 @default.
• W2162880997 cites W2063709616 @default.
• W2162880997 cites W2065668335 @default.
• W2162880997 cites W2071377403 @default.
• W2162880997 cites W2071606041 @default.
• W2162880997 cites W2073652272 @default.
• W2162880997 cites W2078624194 @default.
• W2162880997 cites W2090295661 @default.
• W2162880997 cites W2092933011 @default.
• W2162880997 cites W2093812451 @default.
• W2162880997 cites W2101597757 @default.
• W2162880997 cites W2109726055 @default.
• W2162880997 cites W2133811999 @default.
• W2162880997 cites W2145116035 @default.
• W2162880997 cites W2335311569 @default.
• W2162880997 cites W4241950708 @default.
• W2162880997 cites W4254868516 @default.
• W2162880997 cites W653009 @default.
• W2162880997 doi "https://doi.org/10.1523/jneurosci.2577-05.2005" @default.
• W2162880997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415170" @default.
• W2162880997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16192378" @default.
• W2162880997 hasPublicationYear "2005" @default.
• W2162880997 type Work @default.
• W2162880997 sameAs 2162880997 @default.
• W2162880997 citedByCount "109" @default.
• W2162880997 countsByYear W21628809972012 @default.
• W2162880997 countsByYear W21628809972013 @default.
• W2162880997 countsByYear W21628809972014 @default.
• W2162880997 countsByYear W21628809972015 @default.
• W2162880997 countsByYear W21628809972016 @default.
• W2162880997 countsByYear W21628809972017 @default.
• W2162880997 countsByYear W21628809972018 @default.
• W2162880997 countsByYear W21628809972019 @default.
• W2162880997 countsByYear W21628809972020 @default.
• W2162880997 countsByYear W21628809972021 @default.
• W2162880997 countsByYear W21628809972022 @default.
• W2162880997 countsByYear W21628809972023 @default.
• W2162880997 crossrefType "journal-article" @default.
• W2162880997 hasAuthorship W2162880997A5013260521 @default.
• W2162880997 hasAuthorship W2162880997A5070887960 @default.
• W2162880997 hasAuthorship W2162880997A5073000103 @default.
• W2162880997 hasBestOaLocation W21628809971 @default.
• W2162880997 hasConcept C112592302 @default.
• W2162880997 hasConcept C126322002 @default.
• W2162880997 hasConcept C148762608 @default.
• W2162880997 hasConcept C167734588 @default.
• W2162880997 hasConcept C169760540 @default.
• W2162880997 hasConcept C170493617 @default.
• W2162880997 hasConcept C17077164 @default.
• W2162880997 hasConcept C200170125 @default.
• W2162880997 hasConcept C24998067 @default.
• W2162880997 hasConcept C25498285 @default.
• W2162880997 hasConcept C2776464000 @default.
• W2162880997 hasConcept C2777025900 @default.
• W2162880997 hasConcept C2778039732 @default.
• W2162880997 hasConcept C2780648746 @default.
• W2162880997 hasConcept C2781161787 @default.
• W2162880997 hasConcept C61174792 @default.
• W2162880997 hasConcept C71924100 @default.
• W2162880997 hasConcept C86803240 @default.

• next