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- W2162886201 endingPage "668" @default.
- W2162886201 startingPage "660" @default.
- W2162886201 abstract "Our understanding of asthma has evolved over time from a singular disease to a complex of various phenotypes, with varied natural histories, physiologies, and responses to treatment. Early therapies treated most patients with asthma similarly, with bronchodilators and corticosteroids, but these therapies had varying degrees of success. Similarly, despite initial studies that identified an underlying type 2 inflammation in the airways of patients with asthma, biologic therapies targeted toward these type 2 pathways were unsuccessful in all patients. These observations led to increased interest in phenotyping asthma. Clinical approaches, both biased and later unbiased/statistical approaches to large asthma patient cohorts, identified a variety of patient characteristics, but they also consistently identified the importance of age of onset of disease and the presence of eosinophils in determining clinically relevant phenotypes. These paralleled molecular approaches to phenotyping that developed an understanding that not all patients share a type 2 inflammatory pattern. Using biomarkers to select patients with type 2 inflammation, repeated trials of biologics directed toward type 2 cytokine pathways saw newfound success, confirming the importance of phenotyping in asthma. Further research is needed to clarify additional clinical and molecular phenotypes, validate predictive biomarkers, and identify new areas for possible interventions." @default.
- W2162886201 created "2016-06-24" @default.
- W2162886201 creator A5040784287 @default.
- W2162886201 creator A5043623665 @default.
- W2162886201 creator A5050793109 @default.
- W2162886201 date "2015-09-15" @default.
- W2162886201 modified "2023-10-01" @default.
- W2162886201 title "Evolving Concepts of Asthma" @default.
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