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- W2162911613 abstract "Chemokine ligand-receptor interactions play a pivotal role in cell attraction and cellular trafficking, both in normal tissue homeostasis and in disease. In cancer, chemokine receptor-4 (CXCR4) expression is an adverse prognostic factor. Early clinical studies suggest that targeting CXCR4 with suitable high-affinity antagonists might be a novel means for therapy. In addition to the preclinical evaluation of [(68)Ga]Pentixafor in mice bearing human lymphoma xenografts as an exemplary CXCR4-expressing tumor entity, we report on the first clinical applications of [(68)Ga]Pentixafor-Positron Emission Tomography as a powerful method for CXCR4 imaging in cancer patients. [(68)Ga]Pentixafor binds with high affinity and selectivity to human CXCR4 and exhibits a favorable dosimetry. [(68)Ga]Pentixafor-PET provides images with excellent specificity and contrast. This non-invasive imaging technology for quantitative assessment of CXCR4 expression allows to further elucidate the role of CXCR4/CXCL12 ligand interaction in the pathogenesis and treatment of cancer, cardiovascular diseases and autoimmune and inflammatory disorders." @default.
- W2162911613 created "2016-06-24" @default.
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- W2162911613 date "2015-01-01" @default.
- W2162911613 modified "2023-10-17" @default.
- W2162911613 title "Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging" @default.
- W2162911613 cites W1438161774 @default.
- W2162911613 cites W1544049253 @default.
- W2162911613 cites W1966105418 @default.
- W2162911613 cites W1969733563 @default.
- W2162911613 cites W1972727778 @default.
- W2162911613 cites W1978966626 @default.
- W2162911613 cites W1979071273 @default.
- W2162911613 cites W1987651121 @default.
- W2162911613 cites W1987757775 @default.
- W2162911613 cites W1988850501 @default.
- W2162911613 cites W1989424983 @default.
- W2162911613 cites W1995187882 @default.
- W2162911613 cites W2000980282 @default.
- W2162911613 cites W2003213153 @default.
- W2162911613 cites W2012415615 @default.
- W2162911613 cites W2013443987 @default.
- W2162911613 cites W2015507639 @default.
- W2162911613 cites W2015940746 @default.
- W2162911613 cites W2019032565 @default.
- W2162911613 cites W2021952648 @default.
- W2162911613 cites W2023624246 @default.
- W2162911613 cites W2028354607 @default.
- W2162911613 cites W2030689322 @default.
- W2162911613 cites W2034123573 @default.
- W2162911613 cites W2034573495 @default.
- W2162911613 cites W2040210877 @default.
- W2162911613 cites W2043046186 @default.
- W2162911613 cites W2046432370 @default.
- W2162911613 cites W2047763902 @default.
- W2162911613 cites W2053317788 @default.
- W2162911613 cites W2053911435 @default.
- W2162911613 cites W2059552079 @default.
- W2162911613 cites W2059856492 @default.
- W2162911613 cites W2063918186 @default.
- W2162911613 cites W2067363319 @default.
- W2162911613 cites W2073020845 @default.
- W2162911613 cites W2073874802 @default.
- W2162911613 cites W2077974469 @default.
- W2162911613 cites W2083874968 @default.
- W2162911613 cites W2085876247 @default.
- W2162911613 cites W2093651836 @default.
- W2162911613 cites W2098560257 @default.
- W2162911613 cites W2101262103 @default.
- W2162911613 cites W2101273818 @default.
- W2162911613 cites W2101873015 @default.
- W2162911613 cites W2102089654 @default.
- W2162911613 cites W2103081494 @default.
- W2162911613 cites W2112592817 @default.
- W2162911613 cites W2113129967 @default.
- W2162911613 cites W2113472355 @default.
- W2162911613 cites W2117199255 @default.
- W2162911613 cites W2126639779 @default.
- W2162911613 cites W2127304289 @default.
- W2162911613 cites W2127453233 @default.
- W2162911613 cites W2128743381 @default.
- W2162911613 cites W2128843378 @default.
- W2162911613 cites W2137428036 @default.
- W2162911613 cites W2138669459 @default.
- W2162911613 cites W2142285857 @default.
- W2162911613 cites W2142452022 @default.
- W2162911613 cites W2142892314 @default.
- W2162911613 cites W2145151064 @default.
- W2162911613 cites W2147660186 @default.
- W2162911613 cites W2149250280 @default.
- W2162911613 cites W2149888039 @default.
- W2162911613 cites W2153216820 @default.
- W2162911613 cites W2153787979 @default.
- W2162911613 cites W2154702871 @default.
- W2162911613 cites W2156323704 @default.
- W2162911613 cites W2156624898 @default.
- W2162911613 cites W2157039180 @default.
- W2162911613 cites W2158737833 @default.
- W2162911613 cites W2159483382 @default.
- W2162911613 cites W2159913536 @default.
- W2162911613 cites W2163844917 @default.
- W2162911613 cites W2164381118 @default.
- W2162911613 cites W2164882731 @default.
- W2162911613 cites W232525996 @default.
- W2162911613 cites W2325356047 @default.