Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162912283> ?p ?o ?g. }
- W2162912283 endingPage "2051" @default.
- W2162912283 startingPage "2041" @default.
- W2162912283 abstract "To understand how mammalian genes are regulated from their natural chromosomal environment, we have analysed the molecular events occurring throughout a 150 kb chromatin segment containing the alpha globin gene locus as it changes from a poised, silent state in erythroid progenitors, to the fully activated state in late, erythroid cells. Active transcription requires the late recruitment of general transcription factors, mediator and Pol II not only to the promoter but also to its remote regulatory elements. Natural mutants of the alpha cluster show that whereas recruitment of the pre-initiation complex to the upstream elements occurs independently, recruitment to the promoter is largely dependent on the regulatory elements. An improved, quantitative chromosome conformation capture analysis demonstrates that this recruitment is associated with a conformational change, in vivo, apposing the promoter with its remote regulators, consistent with a chromosome looping mechanism. These findings point to a general mechanism by which a gene can be held in a poised state until the appropriate stage for expression, coordinating the level and timing of gene expression during terminal differentiation." @default.
- W2162912283 created "2016-06-24" @default.
- W2162912283 creator A5005721301 @default.
- W2162912283 creator A5020959667 @default.
- W2162912283 creator A5029557655 @default.
- W2162912283 creator A5031092425 @default.
- W2162912283 creator A5055644792 @default.
- W2162912283 date "2007-03-22" @default.
- W2162912283 modified "2023-09-27" @default.
- W2162912283 title "Long-range chromosomal interactions regulate the timing of the transition between poised and active gene expression" @default.
- W2162912283 cites W1277787372 @default.
- W2162912283 cites W1484529414 @default.
- W2162912283 cites W1841158999 @default.
- W2162912283 cites W1969480944 @default.
- W2162912283 cites W1971615450 @default.
- W2162912283 cites W1973049010 @default.
- W2162912283 cites W1982689821 @default.
- W2162912283 cites W1994711553 @default.
- W2162912283 cites W1994861290 @default.
- W2162912283 cites W2019666363 @default.
- W2162912283 cites W2040544622 @default.
- W2162912283 cites W2046652587 @default.
- W2162912283 cites W2051784499 @default.
- W2162912283 cites W2060255615 @default.
- W2162912283 cites W2060392690 @default.
- W2162912283 cites W2065173155 @default.
- W2162912283 cites W2065703299 @default.
- W2162912283 cites W2067137429 @default.
- W2162912283 cites W2073026107 @default.
- W2162912283 cites W2073340777 @default.
- W2162912283 cites W2076142853 @default.
- W2162912283 cites W2083329762 @default.
- W2162912283 cites W2095358593 @default.
- W2162912283 cites W2098401569 @default.
- W2162912283 cites W2101656044 @default.
- W2162912283 cites W2105640296 @default.
- W2162912283 cites W2109264912 @default.
- W2162912283 cites W2111375636 @default.
- W2162912283 cites W2111885793 @default.
- W2162912283 cites W2114752899 @default.
- W2162912283 cites W2115686505 @default.
- W2162912283 cites W2120702938 @default.
- W2162912283 cites W2122616238 @default.
- W2162912283 cites W2128531085 @default.
- W2162912283 cites W2131382540 @default.
- W2162912283 cites W2147547112 @default.
- W2162912283 cites W2150009446 @default.
- W2162912283 cites W2152699202 @default.
- W2162912283 cites W2152968621 @default.
- W2162912283 cites W2166811005 @default.
- W2162912283 cites W2171393347 @default.
- W2162912283 cites W2171442811 @default.
- W2162912283 doi "https://doi.org/10.1038/sj.emboj.7601654" @default.
- W2162912283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1852780" @default.
- W2162912283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17380126" @default.
- W2162912283 hasPublicationYear "2007" @default.
- W2162912283 type Work @default.
- W2162912283 sameAs 2162912283 @default.
- W2162912283 citedByCount "230" @default.
- W2162912283 countsByYear W21629122832012 @default.
- W2162912283 countsByYear W21629122832013 @default.
- W2162912283 countsByYear W21629122832014 @default.
- W2162912283 countsByYear W21629122832015 @default.
- W2162912283 countsByYear W21629122832016 @default.
- W2162912283 countsByYear W21629122832017 @default.
- W2162912283 countsByYear W21629122832018 @default.
- W2162912283 countsByYear W21629122832019 @default.
- W2162912283 countsByYear W21629122832020 @default.
- W2162912283 countsByYear W21629122832021 @default.
- W2162912283 countsByYear W21629122832022 @default.
- W2162912283 countsByYear W21629122832023 @default.
- W2162912283 crossrefType "journal-article" @default.
- W2162912283 hasAuthorship W2162912283A5005721301 @default.
- W2162912283 hasAuthorship W2162912283A5020959667 @default.
- W2162912283 hasAuthorship W2162912283A5029557655 @default.
- W2162912283 hasAuthorship W2162912283A5031092425 @default.
- W2162912283 hasAuthorship W2162912283A5055644792 @default.
- W2162912283 hasBestOaLocation W21629122831 @default.
- W2162912283 hasConcept C101762097 @default.
- W2162912283 hasConcept C104317684 @default.
- W2162912283 hasConcept C111936080 @default.
- W2162912283 hasConcept C138885662 @default.
- W2162912283 hasConcept C150194340 @default.
- W2162912283 hasConcept C165864922 @default.
- W2162912283 hasConcept C179926584 @default.
- W2162912283 hasConcept C21592294 @default.
- W2162912283 hasConcept C41895202 @default.
- W2162912283 hasConcept C54355233 @default.
- W2162912283 hasConcept C83640560 @default.
- W2162912283 hasConcept C84597430 @default.
- W2162912283 hasConcept C86339819 @default.
- W2162912283 hasConcept C86803240 @default.
- W2162912283 hasConcept C93946551 @default.
- W2162912283 hasConcept C95444343 @default.
- W2162912283 hasConceptScore W2162912283C101762097 @default.
- W2162912283 hasConceptScore W2162912283C104317684 @default.
- W2162912283 hasConceptScore W2162912283C111936080 @default.
- W2162912283 hasConceptScore W2162912283C138885662 @default.