FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2162912453> ?p ?o ?g. }

• W2162912453 abstract "Empirical clinical studies on the human interactome and phenome not only illustrates prevalent phenotypic overlap and genetic overlap between diseases, but also reveals a modular organization of the genetic landscape of human disease, providing new opportunities to reduce the complexity in dissecting the phenotype-genotype association. We here introduce a network-module based method towards phenotype-genotype association inference and disease gene identification. This approach incorporates protein-protein interaction network, phenotype similarity network and known phenotype-genotype associations into an assembled network. We then decomposes the resulted network into modules (or communities) wherein we identified and prioritized the disease genes from the candidates within the loci associated with the query disease using a linear regression model and concordance score. For the known phenotype-gene associations in the OMIM database, we used the leave-one-out validation to evaluate the feasibility of our method, and successfully ranked known disease genes at top 1 in 887 out of 1807 cases. Moreover, applying this approach on 850 OMIM loci characterized by an unknown molecular basis, we propose high-probability candidates for 81 genetic diseases." @default.
• W2162912453 created "2016-06-24" @default.
• W2162912453 creator A5065482772 @default.
• W2162912453 creator A5065732380 @default.
• W2162912453 creator A5072318090 @default.
• W2162912453 date "2010-11-22" @default.
• W2162912453 modified "2023-09-24" @default.
• W2162912453 title "Towards prediction and prioritization of disease genes by the modularity of human phenome-genome assembled network." @default.
• W2162912453 cites W2000364429 @default.
• W2162912453 cites W2020301095 @default.
• W2162912453 cites W2037442572 @default.
• W2162912453 cites W2045131720 @default.
• W2162912453 cites W2056505631 @default.
• W2162912453 cites W2058077802 @default.
• W2162912453 cites W2070448217 @default.
• W2162912453 cites W2081428705 @default.
• W2162912453 cites W2083045667 @default.
• W2162912453 cites W2089458547 @default.
• W2162912453 cites W2095293504 @default.
• W2162912453 cites W2097498614 @default.
• W2162912453 cites W2100025044 @default.
• W2162912453 cites W2104261859 @default.
• W2162912453 cites W2108181223 @default.
• W2162912453 cites W2119943416 @default.
• W2162912453 cites W2123280311 @default.
• W2162912453 cites W2128058093 @default.
• W2162912453 cites W2131581981 @default.
• W2162912453 cites W2144014661 @default.
• W2162912453 cites W2149303478 @default.
• W2162912453 cites W2151936673 @default.
• W2162912453 cites W2154654747 @default.
• W2162912453 cites W2159413587 @default.
• W2162912453 cites W2168822739 @default.
• W2162912453 doi "https://doi.org/10.2390/biecoll-jib-2010-149" @default.
• W2162912453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21098881" @default.
• W2162912453 hasPublicationYear "2010" @default.
• W2162912453 type Work @default.
• W2162912453 sameAs 2162912453 @default.
• W2162912453 citedByCount "2" @default.
• W2162912453 countsByYear W21629124532014 @default.
• W2162912453 crossrefType "journal-article" @default.
• W2162912453 hasAuthorship W2162912453A5065482772 @default.
• W2162912453 hasAuthorship W2162912453A5065732380 @default.
• W2162912453 hasAuthorship W2162912453A5072318090 @default.
• W2162912453 hasConcept C104317684 @default.
• W2162912453 hasConcept C116834253 @default.
• W2162912453 hasConcept C127716648 @default.
• W2162912453 hasConcept C135763542 @default.
• W2162912453 hasConcept C142724271 @default.
• W2162912453 hasConcept C150194340 @default.
• W2162912453 hasConcept C154945302 @default.
• W2162912453 hasConcept C160798450 @default.
• W2162912453 hasConcept C200844832 @default.
• W2162912453 hasConcept C2776214188 @default.
• W2162912453 hasConcept C2779134260 @default.
• W2162912453 hasConcept C2779478453 @default.
• W2162912453 hasConcept C41008148 @default.
• W2162912453 hasConcept C54355233 @default.
• W2162912453 hasConcept C59822182 @default.
• W2162912453 hasConcept C67339327 @default.
• W2162912453 hasConcept C70721500 @default.
• W2162912453 hasConcept C71924100 @default.
• W2162912453 hasConcept C7952369 @default.
• W2162912453 hasConcept C86803240 @default.
• W2162912453 hasConcept C9760119 @default.
• W2162912453 hasConceptScore W2162912453C104317684 @default.
• W2162912453 hasConceptScore W2162912453C116834253 @default.
• W2162912453 hasConceptScore W2162912453C127716648 @default.
• W2162912453 hasConceptScore W2162912453C135763542 @default.
• W2162912453 hasConceptScore W2162912453C142724271 @default.
• W2162912453 hasConceptScore W2162912453C150194340 @default.
• W2162912453 hasConceptScore W2162912453C154945302 @default.
• W2162912453 hasConceptScore W2162912453C160798450 @default.
• W2162912453 hasConceptScore W2162912453C200844832 @default.
• W2162912453 hasConceptScore W2162912453C2776214188 @default.
• W2162912453 hasConceptScore W2162912453C2779134260 @default.
• W2162912453 hasConceptScore W2162912453C2779478453 @default.
• W2162912453 hasConceptScore W2162912453C41008148 @default.
• W2162912453 hasConceptScore W2162912453C54355233 @default.
• W2162912453 hasConceptScore W2162912453C59822182 @default.
• W2162912453 hasConceptScore W2162912453C67339327 @default.
• W2162912453 hasConceptScore W2162912453C70721500 @default.
• W2162912453 hasConceptScore W2162912453C71924100 @default.
• W2162912453 hasConceptScore W2162912453C7952369 @default.
• W2162912453 hasConceptScore W2162912453C86803240 @default.
• W2162912453 hasConceptScore W2162912453C9760119 @default.
• W2162912453 hasIssue "2" @default.
• W2162912453 hasLocation W21629124531 @default.
• W2162912453 hasOpenAccess W2162912453 @default.
• W2162912453 hasPrimaryLocation W21629124531 @default.
• W2162912453 hasRelatedWork W1966250679 @default.
• W2162912453 hasRelatedWork W1973725398 @default.
• W2162912453 hasRelatedWork W1987495103 @default.
• W2162912453 hasRelatedWork W1990564596 @default.
• W2162912453 hasRelatedWork W2048533654 @default.
• W2162912453 hasRelatedWork W2100582962 @default.
• W2162912453 hasRelatedWork W2107638877 @default.
• W2162912453 hasRelatedWork W2125543088 @default.
• W2162912453 hasRelatedWork W2126249571 @default.
• W2162912453 hasRelatedWork W2128245545 @default.

• next