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• W2162918177 endingPage "1987" @default.
• W2162918177 startingPage "1975" @default.
• W2162918177 abstract "ABSTRACT Porphyromonas gingivalis , a Gram-negative oral anaerobe, is strongly associated with chronic adult periodontitis, and it utilizes FimA fimbriae to persistently colonize and evade host defenses in the periodontal crevice. The FimA-related gene cluster (the fim gene cluster) is positively regulated by the FimS-FimR two-component system. In this study, comparative analyses between fimbriate type strain ATCC 33277 and fimbria-deficient strain W83 revealed differences in their fimS loci, which encode FimS histidine kinase. Using a reciprocal gene exchange system, we established that FimS from W83 is malfunctional. Complementation analysis with chimeric fimS constructs revealed that W83 FimS has a defective kinase domain due to a truncated conserved G3 box motif that provides an ATP-binding pocket. The introduction of the functional fimS from 33277 restored the production, but not polymerization, of endogenous FimA subunits in W83. Further analyses with a fimA -exchanged W83 isogenic strain showed that even the fimbria-deficient W83 retains the ability to polymerize FimA from 33277, indicating the assembly of mature FimA by a primary structure-dependent mechanism. It also was shown that the substantial expression of 33277-type FimA fimbriae in the W83 derivative requires the introduction and expression of the functional 33277 fimS . These findings indicate that FimSR is the unique and universal regulatory system that activates the fim gene cluster in a fimA genotype-independent manner." @default.
• W2162918177 created "2016-06-24" @default.
• W2162918177 creator A5058838130 @default.
• W2162918177 creator A5084126375 @default.
• W2162918177 date "2010-04-01" @default.
• W2162918177 modified "2023-10-03" @default.
• W2162918177 title "Histidine Kinase-Mediated Production and Autoassembly of <i>Porphyromonas gingivalis</i> Fimbriae" @default.
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• W2162918177 doi "https://doi.org/10.1128/jb.01474-09" @default.
• W2162918177 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2838039" @default.
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