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• W2162925972 abstract "The reaction of N,N-diethyl carbamates of 1H-[1,2,3]triazolo[4,5-b]pyridin-1-ol (4-HOAt) 7, 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol (7-HOAt) 8, 1H-benzo[d][1,2,3]triazol-1-ol (HOBt) 9, 6-chloro-1H-benzo[d][1,2,3]triazol-1-ol (Cl-HOBt) 10, 6-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-1-ol (<TEX>$CF_3$</TEX>-HOBt) 11, and 6-nitro-1H-benzo[d][1,2,3]triazol-1-ol (<TEX>$NO_2$</TEX>-HOBt) 12 with morpholine and piperidine in <TEX>$CH_3CN$</TEX> underwent acyl nucleophilic substitution to give the corresponding carboxamide derivatives. The reactants and products were identified by elemental analysis, IR and NMR. We measured the kinetics of these reactions spectrophotometrically in <TEX>$CH_3CN$</TEX> at a range of temperatures. The rates of morpholinolysis and piperidinolysis were found to fit the Hammett equation and correlated with <TEX>$sigma$</TEX>-Hammett values. The values were 1.44 - 1.21 for morpholinolysis and 1.95 - 1.72 for piperidinolysis depending on the temperature. The <TEX>$Br{phi}$</TEX>nsted-type plot was linear with a <TEX>$beta_lg = -0.49 pm 0.02$</TEX> and <TEX>$-0.67 pm 0.03$</TEX>. The kinetic data and structure-reactivity relationships indicate that the reaction of 9-12 with amines proceeds by a concerted mechanism. The deviation from linearity of the correlation <TEX>${Delta}H^#$</TEX> vs. <TEX>${Delta}S^#$</TEX> and plot of <TEX>$logk_{pip}$</TEX> vs. <TEX>$logk_{morph}$</TEX> and <TEX>$Br{phi}$</TEX>nsted-type correlation indicate that the reactions of amines with carbamates 7 and 8 is attributed to the electronic nature of their leaving groups." @default.
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• W2162925972 date "2010-01-20" @default.
• W2162925972 modified "2023-10-15" @default.
• W2162925972 title "Synthesis and Aminolysis of N,N-Diethyl Carbamic Ester of HOBt Derivatives" @default.
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• W2162925972 doi "https://doi.org/10.5012/bkcs.2010.31.01.075" @default.
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