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• W2163010775 startingPage "1175" @default.
• W2163010775 abstract "It is still controversial whether cranial placodes and neural crest cells arise from a common precursor at the neural plate border or whether placodes arise from non-neural ectoderm and neural crest from neural ectoderm. Using tissue grafting in embryos of Xenopus laevis, we show here that the competence for induction of neural plate, neural plate border and neural crest markers is confined to neural ectoderm, whereas competence for induction of panplacodal markers is confined to non-neural ectoderm. This differential distribution of competence is established during gastrulation paralleling the dorsal restriction of neural competence. We further show that Dlx3 and GATA2 are required cell-autonomously for panplacodal and epidermal marker expression in the non-neural ectoderm, while ectopic expression of Dlx3 or GATA2 in the neural plate suppresses neural plate, border and crest markers. Overexpression of Dlx3 (but not GATA2) in the neural plate is sufficient to induce different non-neural markers in a signaling-dependent manner, with epidermal markers being induced in the presence, and panplacodal markers in the absence, of BMP signaling. Taken together, these findings demonstrate a non-neural versus neural origin of placodes and neural crest, respectively, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically." @default.
• W2163010775 created "2016-06-24" @default.
• W2163010775 creator A5003125009 @default.
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• W2163010775 creator A5052551861 @default.
• W2163010775 creator A5088301978 @default.
• W2163010775 date "2012-03-15" @default.
• W2163010775 modified "2023-10-10" @default.
• W2163010775 title "Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm" @default.
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• W2163010775 doi "https://doi.org/10.1242/dev.074468" @default.
• W2163010775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22318231" @default.
• W2163010775 hasPublicationYear "2012" @default.
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