FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163018505> ?p ?o ?g. }

• W2163018505 endingPage "1436S" @default.
• W2163018505 startingPage "1432S" @default.
• W2163018505 abstract "The concentration of plasma zinc is the generally accepted index of zinc status. Although low plasma zinc is an essential criterion of deficiency, alone it is inadequate. To supplement this index, we sought to determine the first limiting biochemical defect in animals fed zinc-deficient diets and concluded that the limiting function is associated with a posttranslational change in plasma membrane proteins. Among the signs of zinc deficiency in rats is a bleeding tendency associated with failure of platelet aggregation, a phenomenon that correlates with impaired uptake of Ca(2+) when stimulated. Zinc-deficient guinea pigs exhibit signs of peripheral neuropathy, and their brain synaptic vesicles exhibit impaired Ca(2+) uptake when they are stimulated with glutamate. Red cells from zinc-deficient rats show increased osmotic fragility associated with decreased plasma membrane sulfhydryl concentration. Both phenomena are readily reversed (2 d) by dietary zinc repletion. Volume recovery is dependent on Ca-dependent K channels and the sulfhydryl redox state. Both the impaired aggregation and calcium uptake of zinc-deficient platelets are corrected by in vitro incubation of blood with glutathione. Considering the fact that plasma membranes from several cell types show impaired function that is associated with a decreased rate of calcium uptake, it is postulated that a defect in calcium channels is the first limiting biochemical defect in zinc deficiency. The calcium uptake defect and consequent impaired second-messenger function likely results from an abnormal sulfhydryl redox state in the membrane channel protein." @default.
• W2163018505 created "2016-06-24" @default.
• W2163018505 creator A5026547834 @default.
• W2163018505 date "2000-05-01" @default.
• W2163018505 modified "2023-10-11" @default.
• W2163018505 title "Role of Zinc in Plasma Membrane Function" @default.
• W2163018505 cites W1562923905 @default.
• W2163018505 cites W1852335935 @default.
• W2163018505 cites W1867846340 @default.
• W2163018505 cites W1888076559 @default.
• W2163018505 cites W1895106826 @default.
• W2163018505 cites W1915197178 @default.
• W2163018505 cites W1916733383 @default.
• W2163018505 cites W1967301498 @default.
• W2163018505 cites W1975930777 @default.
• W2163018505 cites W1976913454 @default.
• W2163018505 cites W1989561262 @default.
• W2163018505 cites W2000918176 @default.
• W2163018505 cites W2020163158 @default.
• W2163018505 cites W2023918637 @default.
• W2163018505 cites W2045941321 @default.
• W2163018505 cites W2048211796 @default.
• W2163018505 cites W2052546664 @default.
• W2163018505 cites W2066698014 @default.
• W2163018505 cites W2066791192 @default.
• W2163018505 cites W2070518302 @default.
• W2163018505 cites W2077726139 @default.
• W2163018505 cites W2077774567 @default.
• W2163018505 cites W2078700979 @default.
• W2163018505 cites W2085357653 @default.
• W2163018505 cites W2116367177 @default.
• W2163018505 cites W2140329649 @default.
• W2163018505 cites W2144506443 @default.
• W2163018505 cites W2157929794 @default.
• W2163018505 cites W2326529359 @default.
• W2163018505 doi "https://doi.org/10.1093/jn/130.5.1432s" @default.
• W2163018505 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10801956" @default.
• W2163018505 hasPublicationYear "2000" @default.
• W2163018505 type Work @default.
• W2163018505 sameAs 2163018505 @default.
• W2163018505 citedByCount "166" @default.
• W2163018505 countsByYear W21630185052012 @default.
• W2163018505 countsByYear W21630185052013 @default.
• W2163018505 countsByYear W21630185052014 @default.
• W2163018505 countsByYear W21630185052015 @default.
• W2163018505 countsByYear W21630185052016 @default.
• W2163018505 countsByYear W21630185052017 @default.
• W2163018505 countsByYear W21630185052018 @default.
• W2163018505 countsByYear W21630185052019 @default.
• W2163018505 countsByYear W21630185052020 @default.
• W2163018505 countsByYear W21630185052021 @default.
• W2163018505 countsByYear W21630185052022 @default.
• W2163018505 countsByYear W21630185052023 @default.
• W2163018505 crossrefType "journal-article" @default.
• W2163018505 hasAuthorship W2163018505A5026547834 @default.
• W2163018505 hasBestOaLocation W21630185051 @default.
• W2163018505 hasConcept C126322002 @default.
• W2163018505 hasConcept C134018914 @default.
• W2163018505 hasConcept C178790620 @default.
• W2163018505 hasConcept C181199279 @default.
• W2163018505 hasConcept C185592680 @default.
• W2163018505 hasConcept C2776928490 @default.
• W2163018505 hasConcept C519063684 @default.
• W2163018505 hasConcept C535196362 @default.
• W2163018505 hasConcept C538909803 @default.
• W2163018505 hasConcept C55493867 @default.
• W2163018505 hasConcept C71924100 @default.
• W2163018505 hasConcept C86803240 @default.
• W2163018505 hasConcept C89560881 @default.
• W2163018505 hasConceptScore W2163018505C126322002 @default.
• W2163018505 hasConceptScore W2163018505C134018914 @default.
• W2163018505 hasConceptScore W2163018505C178790620 @default.
• W2163018505 hasConceptScore W2163018505C181199279 @default.
• W2163018505 hasConceptScore W2163018505C185592680 @default.
• W2163018505 hasConceptScore W2163018505C2776928490 @default.
• W2163018505 hasConceptScore W2163018505C519063684 @default.
• W2163018505 hasConceptScore W2163018505C535196362 @default.
• W2163018505 hasConceptScore W2163018505C538909803 @default.
• W2163018505 hasConceptScore W2163018505C55493867 @default.
• W2163018505 hasConceptScore W2163018505C71924100 @default.
• W2163018505 hasConceptScore W2163018505C86803240 @default.
• W2163018505 hasConceptScore W2163018505C89560881 @default.
• W2163018505 hasIssue "5" @default.
• W2163018505 hasLocation W21630185051 @default.
• W2163018505 hasLocation W21630185052 @default.
• W2163018505 hasOpenAccess W2163018505 @default.
• W2163018505 hasPrimaryLocation W21630185051 @default.
• W2163018505 hasRelatedWork W1899341428 @default.
• W2163018505 hasRelatedWork W1916733383 @default.
• W2163018505 hasRelatedWork W1974382241 @default.
• W2163018505 hasRelatedWork W2003842308 @default.
• W2163018505 hasRelatedWork W2025590009 @default.
• W2163018505 hasRelatedWork W2041709845 @default.
• W2163018505 hasRelatedWork W2064236298 @default.
• W2163018505 hasRelatedWork W2091692267 @default.
• W2163018505 hasRelatedWork W2095093072 @default.
• W2163018505 hasRelatedWork W2126072608 @default.
• W2163018505 hasVolume "130" @default.

• next