FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163053669> ?p ?o ?g. }

• W2163053669 endingPage "401" @default.
• W2163053669 startingPage "397" @default.
• W2163053669 abstract "Although radiation-induced heritable damage in mammalian cells was thought to result from the direct interaction of radiation with DNA, it is now accepted that biological effects may occur in cells that were not themselves traversed by ionizing radiation but are close to those that were. However, little is known about the mechanism underlying such a bystander effect, although cell-to-cell communication is thought to be of importance. Previous work using the Columbia microbeam demonstrated a significant bystander effect for clonogenic survival and oncogenic transformation in C3H 10T(1/2) cells. The present study was undertaken to assess the importance of the degree of cell-to-cell contact at the time of irradiation on the magnitude of this bystander effect by varying the cell density. When 10% of cells were exposed to a range of 2-12 alpha particles, a significantly greater number of cells (P < 0.0001) were inactivated when cells were irradiated at high density (>90% in contact with neighbors) than at low density (<10% in contact). In addition, the oncogenic transformation frequency was significantly higher in high-density cultures (P < 0.0004). These results suggest that when a cell is hit by radiation, the transmission of the bystander signal through cell-to-cell contact is an important mediator of the effect, implicating the involvement of intracellular communication through gap junctions." @default.
• W2163053669 created "2016-06-24" @default.
• W2163053669 creator A5011597168 @default.
• W2163053669 creator A5016333044 @default.
• W2163053669 creator A5048201953 @default.
• W2163053669 creator A5088080267 @default.
• W2163053669 date "2004-04-01" @default.
• W2163053669 modified "2023-09-23" @default.
• W2163053669 title "The Bystander Response in C3H 10T½ Cells: The Influence of Cell-to-Cell Contact" @default.
• W2163053669 cites W1982333316 @default.
• W2163053669 cites W2004828624 @default.
• W2163053669 cites W2008892157 @default.
• W2163053669 cites W2036729701 @default.
• W2163053669 cites W2039341350 @default.
• W2163053669 cites W2056632309 @default.
• W2163053669 cites W2066537849 @default.
• W2163053669 cites W2075497030 @default.
• W2163053669 cites W2077478515 @default.
• W2163053669 cites W2084205200 @default.
• W2163053669 cites W2089741467 @default.
• W2163053669 cites W2101331356 @default.
• W2163053669 cites W2110928379 @default.
• W2163053669 cites W2132305988 @default.
• W2163053669 cites W2148231564 @default.
• W2163053669 cites W2153430949 @default.
• W2163053669 cites W2155946551 @default.
• W2163053669 cites W2164856505 @default.
• W2163053669 cites W2166522896 @default.
• W2163053669 cites W2167894711 @default.
• W2163053669 cites W2172757785 @default.
• W2163053669 cites W2173782486 @default.
• W2163053669 cites W2174360749 @default.
• W2163053669 cites W4232293882 @default.
• W2163053669 cites W4248517883 @default.
• W2163053669 doi "https://doi.org/10.1667/rr3137" @default.
• W2163053669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15038773" @default.
• W2163053669 hasPublicationYear "2004" @default.
• W2163053669 type Work @default.
• W2163053669 sameAs 2163053669 @default.
• W2163053669 citedByCount "73" @default.
• W2163053669 countsByYear W21630536692012 @default.
• W2163053669 countsByYear W21630536692013 @default.
• W2163053669 countsByYear W21630536692014 @default.
• W2163053669 countsByYear W21630536692015 @default.
• W2163053669 countsByYear W21630536692016 @default.
• W2163053669 countsByYear W21630536692017 @default.
• W2163053669 countsByYear W21630536692018 @default.
• W2163053669 countsByYear W21630536692019 @default.
• W2163053669 countsByYear W21630536692021 @default.
• W2163053669 countsByYear W21630536692022 @default.
• W2163053669 crossrefType "journal-article" @default.
• W2163053669 hasAuthorship W2163053669A5011597168 @default.
• W2163053669 hasAuthorship W2163053669A5016333044 @default.
• W2163053669 hasAuthorship W2163053669A5048201953 @default.
• W2163053669 hasAuthorship W2163053669A5088080267 @default.
• W2163053669 hasBestOaLocation W21630536692 @default.
• W2163053669 hasConcept C111337013 @default.
• W2163053669 hasConcept C117262875 @default.
• W2163053669 hasConcept C121332964 @default.
• W2163053669 hasConcept C12554922 @default.
• W2163053669 hasConcept C1491633281 @default.
• W2163053669 hasConcept C18231593 @default.
• W2163053669 hasConcept C185544564 @default.
• W2163053669 hasConcept C189014844 @default.
• W2163053669 hasConcept C19106626 @default.
• W2163053669 hasConcept C203014093 @default.
• W2163053669 hasConcept C54355233 @default.
• W2163053669 hasConcept C62112901 @default.
• W2163053669 hasConcept C64979461 @default.
• W2163053669 hasConcept C79879829 @default.
• W2163053669 hasConcept C81885089 @default.
• W2163053669 hasConcept C86803240 @default.
• W2163053669 hasConcept C95444343 @default.
• W2163053669 hasConceptScore W2163053669C111337013 @default.
• W2163053669 hasConceptScore W2163053669C117262875 @default.
• W2163053669 hasConceptScore W2163053669C121332964 @default.
• W2163053669 hasConceptScore W2163053669C12554922 @default.
• W2163053669 hasConceptScore W2163053669C1491633281 @default.
• W2163053669 hasConceptScore W2163053669C18231593 @default.
• W2163053669 hasConceptScore W2163053669C185544564 @default.
• W2163053669 hasConceptScore W2163053669C189014844 @default.
• W2163053669 hasConceptScore W2163053669C19106626 @default.
• W2163053669 hasConceptScore W2163053669C203014093 @default.
• W2163053669 hasConceptScore W2163053669C54355233 @default.
• W2163053669 hasConceptScore W2163053669C62112901 @default.
• W2163053669 hasConceptScore W2163053669C64979461 @default.
• W2163053669 hasConceptScore W2163053669C79879829 @default.
• W2163053669 hasConceptScore W2163053669C81885089 @default.
• W2163053669 hasConceptScore W2163053669C86803240 @default.
• W2163053669 hasConceptScore W2163053669C95444343 @default.
• W2163053669 hasIssue "4" @default.
• W2163053669 hasLocation W21630536691 @default.
• W2163053669 hasLocation W21630536692 @default.
• W2163053669 hasLocation W21630536693 @default.
• W2163053669 hasOpenAccess W2163053669 @default.
• W2163053669 hasPrimaryLocation W21630536691 @default.
• W2163053669 hasRelatedWork W1506389291 @default.
• W2163053669 hasRelatedWork W1965454525 @default.

• next