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- W2163063631 abstract "Active cancer is one of the most well known causes of an acquired prothrombotic state [ [1] Wun T. White R.H. Venous thromboembolism (VTE) in patients with cancer: epidemiology and risk factors. Cancer Invest. 2009; 27: 63-74 Crossref PubMed Scopus (130) Google Scholar ]. No global test that can be used routinely to monitor the development of hypercoagulability in these patients is known. Recently our group described elevated plasma levels of the complex between activated factor VII and antithrombin (FVIIa-AT) in subjects, both adults and children, who had had a previous thrombotic event [ 2 Spiezia L. Rossetto V. Campello E. Gavasso S. Woodhams B. Tormene D. et al. Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis. Thromb Haemost. 2010; 103: 1188-1192 Crossref PubMed Scopus (32) Google Scholar , 3 Spiezia L. Campello E. Gentilomo C. Gavasso S. Woodhams B. Laverda A.M. et al. Factor VIIa-antithrombin complexes in children with ischemic stroke. Thromb Res. 2011; 128: 303-304 Abstract Full Text Full Text PDF PubMed Scopus (10) Google Scholar ]. Due to the higher risk of recurrence we consider these subjects to have a hypercoagulable condition and speculated on a possible use of increased plasma levels of FVIIa-AT complex as a marker of a hypercoagulable state. The “molecular” rationale of this association is the fact that FVIIa-AT plasma levels reflect the degree of intravascular exposure of tissue factor (TF) to the blood and consequently the activation of the clotting cascade [ [4] Smith S.A. Antonaci F.C. Woodhams B.J. Morrissey J.H. Factor VIIA-antithrombin complexes in human plasma. XXI Congress of the International Society on Thrombosis and Haemostasis in Geneva, Switzerland, July 2007. J Thromb Haemost. 2007; 5 ([Abstract O-S-040]) Google Scholar ]. The aim of the present retrospective case-control study was to evaluate the FVIIa-AT complex plasma levels in subjects with cancer, with and without an acute thrombotic event, in order to evaluate if FVIIa-AT levels can be used as a global marker of increased hypercoagulability in cancer patients." @default.
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- W2163063631 date "2012-06-01" @default.
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- W2163063631 title "Factor VIIa-antithrombin complexes plasma levels in cancer patients with and without thrombosis" @default.
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- W2163063631 doi "https://doi.org/10.1016/j.thromres.2012.02.046" @default.
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