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- W2163069441 abstract "The activation of PPARγ by ligands, including conjugated linoleic acid (CLA) isomers, plays an important role in the immune response. Among CLA isomers, trans -10, cis -12 ( t 10 c 12)-CLA is known to participate in the modulation of pro-inflammatory cytokine secretion. The aim of the present study was to assess the effect of t 10 c 12-CLA on PPARγ activation, NF-κB activation and TNF-α expression in lipopolysaccharide (LPS)-naive and LPS-stimulated porcine peripheral blood mononuclear cells (PBMC). In addition, the effect of PPARγ inhibition on NF-κB activation and TNF-α expression in porcine PBMC was examined. t 10 c 12-CLA was found to increase TNF-α expression and NF-κB activity in LPS-naive porcine PBMC. In contrast, t 10 c 12-CLA decreased TNF-α expression and NF-κB activity in LPS-stimulated porcine PBMC. t 10 c 12-CLA up-regulated PPARγ activity and mRNA expression in both LPS-naive and LPS-stimulated porcine PBMC. GW9662, a PPARγ antagonist, completely negated the modulating effects of t 10 c 12-CLA on TNF-α expression and NF-κB activity in both LPS-naive and LPS-stimulated porcine PBMC. These results suggest that t 10 c 12-CLA can modulate TNF-α production and NF-κB activation by a PPARγ-dependent pathway in porcine PBMC." @default.
- W2163069441 created "2016-06-24" @default.
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- W2163069441 date "2010-12-23" @default.
- W2163069441 modified "2023-09-26" @default.
- W2163069441 title "<i>Trans</i>-10,<i>cis</i>-12-conjugated linoleic acid modulates NF-κB activation and TNF-α production in porcine peripheral blood mononuclear cells via a PPARγ-dependent pathway" @default.
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- W2163069441 doi "https://doi.org/10.1017/s000711451000499x" @default.
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