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• W2163075708 abstract "Airway smooth muscle (ASM) contracts partly due to an increase in cytosolic Ca 2+ . In this work, we found that the contraction caused by histamine depends on external Na + , possibly involving nonselective cationic channels (NSCC) and the Na + /Ca 2+ exchanger (NCX). We performed various protocols using isometric force measurement of guinea pig tracheal rings stimulated by histamine. We observed that force reached 53 ± 1% of control during external Na + substitution by N-methyl-d-glucamine + , whereas substitution by Li + led to no significant change (91 ± 1%). Preincubation with KB-R7943 decreased the maximal force developed (52.3 ± 5.6%), whereas preincubation with nifedipine did not (89.7 ± 1.8%). Also, application of the nonspecific NCX blocker KB-R7943 and nifedipine on histamine-precontracted tracheal rings reduced force to 1 ± 3%, significantly different from nifedipine alone (49 ± 6%). Moreover, nonspecific NSCC inhibitors SKF-96365 and 2-aminoethyldiphenyl borate reduced force to 1 ± 1% and 19 ± 7%, respectively. Intracellular Ca 2+ measurements in isolated ASM cells showed that KB-R7943 and SKF-96365 reduced the peak and sustained response to histamine (0.20 ± 0.1 and 0.19 ± 0.09 for KB-R, 0.43 ± 0.16 and 0.47 ± 0.18 for SKF, expressed as mean of differences). Moreover, Na + -free solution only inhibited the sustained response (0.54 ± 0.25). These data support an important role for NSCC and NCX during histamine stimulation. We speculate that histamine induces Na + influx through NSCC that promotes the Ca 2+ entry mode of NCX and Ca V 1.2 channel activation, thereby causing contraction." @default.
• W2163075708 created "2016-06-24" @default.
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• W2163075708 date "2007-07-01" @default.
• W2163075708 modified "2023-10-11" @default.
• W2163075708 title "Functional coupling between the Na⁺/Ca²⁺ exchanger and nonselective cation channels during histamine stimulation in guinea pig tracheal smooth muscle" @default.
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• W2163075708 doi "https://doi.org/10.1152/ajplung.00485.2006" @default.
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