Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163094665> ?p ?o ?g. }
- W2163094665 endingPage "928" @default.
- W2163094665 startingPage "914" @default.
- W2163094665 abstract "Interactions of 10-kDa Mycobacterium tuberculosis secretory antigen (MTSA) with dendritic cells (DCs) were investigated to elucidate the role of secretory antigens in regulating immune responses to M. tuberculosis early in the course of infection. MTSA induced the maturation of different DC subsets. The cytokine profiles of these DCs were characteristic to each DC subset. Of interest, coculture of M. tuberculosis whole-cell extract (CE)-pulsed, MTSA-matured DCs with CE-specific T cells led to a marked reduction in interleukin (IL)-2 and interferon (IFN)-gamma production, thereby down-regulating proinflammatory responses to mycobacterial antigens. Attenuation of IL-2 and IFN-gamma levels of CE-specific T cells also was obtained when M. tuberculosis culture filtrate protein-activated DCs were employed as antigen-presenting cells, which suggests that MTSAs induce maturation of DCs at sites of infection, probably to down-regulate proinflammatory immune responses to mycobacteria that may subsequently be released from infected macrophages." @default.
- W2163094665 created "2016-06-24" @default.
- W2163094665 creator A5001130058 @default.
- W2163094665 creator A5002816280 @default.
- W2163094665 creator A5007846978 @default.
- W2163094665 creator A5041269746 @default.
- W2163094665 creator A5050008242 @default.
- W2163094665 date "2003-03-15" @default.
- W2163094665 modified "2023-10-03" @default.
- W2163094665 title "Down‐Regulation of T Helper 1 Responses to Mycobacterial Antigens Due to Maturation of Dendritic Cells by 10‐kDa<i>Mycobacterium tuberculosis</i>Secretory Antigen" @default.
- W2163094665 cites W1493304475 @default.
- W2163094665 cites W1499635692 @default.
- W2163094665 cites W1501972147 @default.
- W2163094665 cites W1507372145 @default.
- W2163094665 cites W1536595294 @default.
- W2163094665 cites W1538029215 @default.
- W2163094665 cites W1543888238 @default.
- W2163094665 cites W1579273204 @default.
- W2163094665 cites W1597086056 @default.
- W2163094665 cites W1604363681 @default.
- W2163094665 cites W1661544713 @default.
- W2163094665 cites W1683960100 @default.
- W2163094665 cites W1794218861 @default.
- W2163094665 cites W1827857989 @default.
- W2163094665 cites W1874659400 @default.
- W2163094665 cites W1905061145 @default.
- W2163094665 cites W1960939533 @default.
- W2163094665 cites W1965338154 @default.
- W2163094665 cites W1973472685 @default.
- W2163094665 cites W1979083093 @default.
- W2163094665 cites W1990909429 @default.
- W2163094665 cites W1999498760 @default.
- W2163094665 cites W2014385809 @default.
- W2163094665 cites W2016042447 @default.
- W2163094665 cites W2028121061 @default.
- W2163094665 cites W2035572849 @default.
- W2163094665 cites W2053405315 @default.
- W2163094665 cites W2053655431 @default.
- W2163094665 cites W2054123743 @default.
- W2163094665 cites W2075477269 @default.
- W2163094665 cites W2078450673 @default.
- W2163094665 cites W2083263336 @default.
- W2163094665 cites W2089380926 @default.
- W2163094665 cites W2095838203 @default.
- W2163094665 cites W2100124012 @default.
- W2163094665 cites W2100894095 @default.
- W2163094665 cites W2103425201 @default.
- W2163094665 cites W2104190613 @default.
- W2163094665 cites W2110317022 @default.
- W2163094665 cites W2123463800 @default.
- W2163094665 cites W2129129629 @default.
- W2163094665 cites W2130074351 @default.
- W2163094665 cites W2130615964 @default.
- W2163094665 cites W2134425543 @default.
- W2163094665 cites W2138582125 @default.
- W2163094665 cites W2145584783 @default.
- W2163094665 cites W2146656619 @default.
- W2163094665 cites W2148320237 @default.
- W2163094665 cites W2149349606 @default.
- W2163094665 cites W2149606224 @default.
- W2163094665 cites W2150564865 @default.
- W2163094665 cites W2157157664 @default.
- W2163094665 cites W2157559696 @default.
- W2163094665 cites W2158204548 @default.
- W2163094665 cites W2163964526 @default.
- W2163094665 cites W2166635511 @default.
- W2163094665 cites W2166676682 @default.
- W2163094665 cites W2169999203 @default.
- W2163094665 cites W2411418705 @default.
- W2163094665 cites W2516253851 @default.
- W2163094665 cites W29783926 @default.
- W2163094665 doi "https://doi.org/10.1086/368173" @default.
- W2163094665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12660938" @default.
- W2163094665 hasPublicationYear "2003" @default.
- W2163094665 type Work @default.
- W2163094665 sameAs 2163094665 @default.
- W2163094665 citedByCount "38" @default.
- W2163094665 countsByYear W21630946652012 @default.
- W2163094665 countsByYear W21630946652015 @default.
- W2163094665 countsByYear W21630946652016 @default.
- W2163094665 countsByYear W21630946652017 @default.
- W2163094665 countsByYear W21630946652018 @default.
- W2163094665 countsByYear W21630946652020 @default.
- W2163094665 countsByYear W21630946652021 @default.
- W2163094665 countsByYear W21630946652023 @default.
- W2163094665 crossrefType "journal-article" @default.
- W2163094665 hasAuthorship W2163094665A5001130058 @default.
- W2163094665 hasAuthorship W2163094665A5002816280 @default.
- W2163094665 hasAuthorship W2163094665A5007846978 @default.
- W2163094665 hasAuthorship W2163094665A5041269746 @default.
- W2163094665 hasAuthorship W2163094665A5050008242 @default.
- W2163094665 hasBestOaLocation W21630946651 @default.
- W2163094665 hasConcept C142724271 @default.
- W2163094665 hasConcept C147483822 @default.
- W2163094665 hasConcept C164027704 @default.
- W2163094665 hasConcept C203014093 @default.
- W2163094665 hasConcept C2776090121 @default.
- W2163094665 hasConcept C2776914184 @default.