FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163110519> ?p ?o ?g. }

• W2163110519 endingPage "9896" @default.
• W2163110519 startingPage "9889" @default.
• W2163110519 abstract "ABSTRACT Herpes simplex virus genes are predominantly intronless. We identified cis -acting elements in the intronless herpes simplex virus type 1 thymidine kinase (TK) gene that facilitate intron-independent gene expression. TK sequences functionally replaced the hepatitis B virus (HBV) posttranscriptional regulatory element (PRE) by inducing the expression of the intronless HBV surface message. TK also activated the pDM138 assay by inducing the cytoplasmic accumulation of intron-containing RNA. Multiple cis -acting RNA sequences, or subelements, that induce cytoplasmic localization of unspliced RNA were mapped within the TK gene. The presence of multiple RNA subelements within the TK gene is reminiscent of the multiple subelements in the HBV PRE required for the cytoplasmic accumulation of intronless HBV RNAs. Similar to HBV PRE subelements, duplication of a single TK subelement resulted in greater-than-additive increases in activity. A reporter chimera containing a single TK subelement juxtaposed to an HBV PRE subelement demonstrated a commensurate increase in activity. These results suggest that viral intronless genes utilize a similar strategy for intron-independent gene expression that requires multiple cis -acting RNA signals. Furthermore, like HBV PRE-containing RNA, TK cytoplasmic localization is not sensitive to leptomycin B, a drug that inhibits the export of proteins containing nuclear export signals. From this, we conclude that proteins that bind TK and facilitate its cytoplasmic accumulation do not travel through a CRM1-dependent RNA transport pathway." @default.
• W2163110519 created "2016-06-24" @default.
• W2163110519 creator A5009527416 @default.
• W2163110519 creator A5033936992 @default.
• W2163110519 date "1998-12-01" @default.
• W2163110519 modified "2023-09-24" @default.
• W2163110519 title "Splicing-Independent Expression of the Herpes Simplex Virus Type 1 Thymidine Kinase Gene Is Mediated by Three cis -Acting RNA Subelements" @default.
• W2163110519 cites W1510096565 @default.
• W2163110519 cites W1536543507 @default.
• W2163110519 cites W1562998360 @default.
• W2163110519 cites W1567396361 @default.
• W2163110519 cites W1783181079 @default.
• W2163110519 cites W1792619367 @default.
• W2163110519 cites W1839111748 @default.
• W2163110519 cites W1843147791 @default.
• W2163110519 cites W1867411047 @default.
• W2163110519 cites W1963143659 @default.
• W2163110519 cites W1977013948 @default.
• W2163110519 cites W2006301581 @default.
• W2163110519 cites W2006467763 @default.
• W2163110519 cites W2013313513 @default.
• W2163110519 cites W2032785100 @default.
• W2163110519 cites W2038256325 @default.
• W2163110519 cites W2042170550 @default.
• W2163110519 cites W2042299243 @default.
• W2163110519 cites W2050263649 @default.
• W2163110519 cites W2050904457 @default.
• W2163110519 cites W2069490539 @default.
• W2163110519 cites W2077812220 @default.
• W2163110519 cites W2091856409 @default.
• W2163110519 cites W2098159363 @default.
• W2163110519 cites W2116445024 @default.
• W2163110519 cites W2126238684 @default.
• W2163110519 cites W2137250220 @default.
• W2163110519 cites W2143538824 @default.
• W2163110519 cites W2152100889 @default.
• W2163110519 cites W2171258458 @default.
• W2163110519 cites W4249680089 @default.
• W2163110519 doi "https://doi.org/10.1128/jvi.72.12.9889-9896.1998" @default.
• W2163110519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/110501" @default.
• W2163110519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9811725" @default.
• W2163110519 hasPublicationYear "1998" @default.
• W2163110519 type Work @default.
• W2163110519 sameAs 2163110519 @default.
• W2163110519 citedByCount "20" @default.
• W2163110519 countsByYear W21631105192012 @default.
• W2163110519 countsByYear W21631105192017 @default.
• W2163110519 crossrefType "journal-article" @default.
• W2163110519 hasAuthorship W2163110519A5009527416 @default.
• W2163110519 hasAuthorship W2163110519A5033936992 @default.
• W2163110519 hasBestOaLocation W21631105191 @default.
• W2163110519 hasConcept C104317684 @default.
• W2163110519 hasConcept C150194340 @default.
• W2163110519 hasConcept C153911025 @default.
• W2163110519 hasConcept C159047783 @default.
• W2163110519 hasConcept C190062978 @default.
• W2163110519 hasConcept C2522874641 @default.
• W2163110519 hasConcept C2781196997 @default.
• W2163110519 hasConcept C41282012 @default.
• W2163110519 hasConcept C54355233 @default.
• W2163110519 hasConcept C54458228 @default.
• W2163110519 hasConcept C67705224 @default.
• W2163110519 hasConcept C86803240 @default.
• W2163110519 hasConcept C94671646 @default.
• W2163110519 hasConcept C95444343 @default.
• W2163110519 hasConceptScore W2163110519C104317684 @default.
• W2163110519 hasConceptScore W2163110519C150194340 @default.
• W2163110519 hasConceptScore W2163110519C153911025 @default.
• W2163110519 hasConceptScore W2163110519C159047783 @default.
• W2163110519 hasConceptScore W2163110519C190062978 @default.
• W2163110519 hasConceptScore W2163110519C2522874641 @default.
• W2163110519 hasConceptScore W2163110519C2781196997 @default.
• W2163110519 hasConceptScore W2163110519C41282012 @default.
• W2163110519 hasConceptScore W2163110519C54355233 @default.
• W2163110519 hasConceptScore W2163110519C54458228 @default.
• W2163110519 hasConceptScore W2163110519C67705224 @default.
• W2163110519 hasConceptScore W2163110519C86803240 @default.
• W2163110519 hasConceptScore W2163110519C94671646 @default.
• W2163110519 hasConceptScore W2163110519C95444343 @default.
• W2163110519 hasIssue "12" @default.
• W2163110519 hasLocation W21631105191 @default.
• W2163110519 hasLocation W21631105192 @default.
• W2163110519 hasLocation W21631105193 @default.
• W2163110519 hasLocation W21631105194 @default.
• W2163110519 hasOpenAccess W2163110519 @default.
• W2163110519 hasPrimaryLocation W21631105191 @default.
• W2163110519 hasRelatedWork W1779159181 @default.
• W2163110519 hasRelatedWork W1985545607 @default.
• W2163110519 hasRelatedWork W2008921111 @default.
• W2163110519 hasRelatedWork W2028299201 @default.
• W2163110519 hasRelatedWork W2088708147 @default.
• W2163110519 hasRelatedWork W2107247282 @default.
• W2163110519 hasRelatedWork W2163285239 @default.
• W2163110519 hasRelatedWork W2414433238 @default.
• W2163110519 hasRelatedWork W2891310908 @default.
• W2163110519 hasRelatedWork W3208063106 @default.
• W2163110519 hasVolume "72" @default.
• W2163110519 isParatext "false" @default.

• next