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- W2163117814 abstract "Pyrimethamine (PM) plus sulfadoxine (SD) is the last remaining affordable drug for treating uncomplicated malaria in Africa. The selective pressure exerted by the slowly eliminated combination PM/SD was compared with that exerted by the more rapidly eliminated combination chlorproguanil/dapsone (CPG/Dap) on Kenyan Plasmodium falciparum. Point mutations were analyzed in dihydrofolate reductase and dihydropteroate synthase and in the genetic diversity of 3 genes in isolates collected before and after CPG/Dap and PM/SD treatments. PM/SD was associated strongly with the disappearance of fully drug-sensitive parasites and with a significant increase in the prevalence of resistant parasites in subsequent parasitemias. However, this was not a characteristic of treatment with CPG/Dap. Moreover, most of the patients who returned with recrudescent infections were in the PM/SD-treated group. The data predict a longer useful therapeutic life for CPG/Dap than for PM/SD, and, thus, CPG/Dap is a preferable alternative for treatment of chloroquine-resistant falciparum malaria in sub-Saharan Africa." @default.
- W2163117814 created "2016-06-24" @default.
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- W2163117814 date "2000-06-01" @default.
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- W2163117814 title "Molecular Evidence of Greater Selective Pressure for Drug Resistance Exerted by the Long‐Acting Antifolate Pyrimethamine/Sulfadoxine Compared with the Shorter‐Acting Chlorproguanil/Dapsone on Kenyan<i>Plasmodium falciparum</i>" @default.
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- W2163117814 doi "https://doi.org/10.1086/315520" @default.
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