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• W2163127949 abstract "<h3>Objective</h3> To determine the analgesic efficacy and safety of intravenous single-dose paracetamol versus morphine in patients presenting to the emergency department with renal colic. <h3>Methods</h3> A randomised double-blind study was performed to compare the efficacy of intravenous paracetamol (1 g) and 0.1 mg/kg morphine in patients with renal colic. The efficacy of the study drugs was measured by a visual analogue scale and a verbal rating scale at baseline and after 15 and 30 min. The adverse effects and need for rescue medication (1 μg/kg intravenous fentanyl) were also recorded at the end of the study. <h3>Results</h3> 133 patients were eligible for enrolment in the study, with 73 patients included in the final analysis (38 in the paracetamol group and 35 in the morphine group). The mean±SD age of the subjects was 30.2±8.6 years and 51 (70%) were men. The mean reduction in scores at 30 min after study drug administration was 63.7 mm (95% CI 57 to 71) for paracetamol and 56.6 mm (95% CI 48 to 65) for morphine. The difference between pain reduction scores for the two groups at 30 min was 7.1 mm (95% CI −18 to 4), demonstrating no statistical or clinical significance. Two adverse events (5.3%) were recorded in the paracetamol group and five (14.3%) in the morphine group (difference 9%, 95% CI −7% to 26%). <h3>Conclusion</h3> Intravenous paracetamol is effective in treating patients presenting with renal colic to the emergency department. <h3>Clinical trials registration no</h3> ClinicalTrials.gov ID number NCT01318187." @default.
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• W2163127949 date "2011-12-20" @default.
• W2163127949 modified "2023-09-27" @default.
• W2163127949 title "Intravenous paracetamol versus morphine for renal colic in the emergency department: a randomised double-blind controlled trial" @default.
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• W2163127949 doi "https://doi.org/10.1136/emermed-2011-200165" @default.
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