FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163173726> ?p ?o ?g. }

• W2163173726 endingPage "836" @default.
• W2163173726 startingPage "831" @default.
• W2163173726 abstract "Abstract BACKGROUND Gastrin measurements are performed primarily for the diagnosis of gastrin-producing tumors, gastrinomas, which cause the Zollinger–Ellison syndrome (ZES). Gastrin circulates as several bioactive peptides, however, and the peptide pattern in gastrinoma patients often deviates from normal. Therefore, it is necessary to measure all forms of gastrin. CONTENT Only immunoassays are useful for measurement of gastrin in plasma. The original assays were RIAs developed in research laboratories that used antibodies directed against the C terminus of gastrin peptides. Because the C-terminal tetrapeptide amide sequence constitutes the active site of gastrin peptides, these assays were well suited for gastrinoma diagnosis. More recently, however, most clinical chemistry laboratories have switched to commercial kits. Because of recent cases of kit-measured normogastrinemia in patients with ZES symptoms, the diagnostic sensitivity and analytical specificity of the available kits have been examined. The results show that gastrin kits frequently measure falsely low concentrations because they measure only a single gastrin form. Falsely high concentrations were also encountered, owing to overreactivity with O-sulfated gastrins or plasma proteins. Thus, more than half of the gastrin kits on the market are unsuited for diagnostics. SUMMARY Gastrinomas are neuroendocrine tumors, some of which become malignant. A delay in diagnosis leads to fulminant ZES, with major, even lethal, complications. Consequently, it is necessary that the diagnostic sensitivity of gastrin kits be adequate. This diagnostic sensitivity requires antibodies that bind the C-terminal epitope of bioactive gastrins without the influence of O-sulfation." @default.
• W2163173726 created "2016-06-24" @default.
• W2163173726 creator A5010676456 @default.
• W2163173726 creator A5027294958 @default.
• W2163173726 creator A5029808098 @default.
• W2163173726 creator A5085229618 @default.
• W2163173726 creator A5091673364 @default.
• W2163173726 date "2012-05-01" @default.
• W2163173726 modified "2023-10-16" @default.
• W2163173726 title "Pitfalls in Diagnostic Gastrin Measurements" @default.
• W2163173726 cites W122818534 @default.
• W2163173726 cites W1670690521 @default.
• W2163173726 cites W1724200113 @default.
• W2163173726 cites W1822950385 @default.
• W2163173726 cites W1973167487 @default.
• W2163173726 cites W1973847770 @default.
• W2163173726 cites W1983447573 @default.
• W2163173726 cites W1992719090 @default.
• W2163173726 cites W1993899869 @default.
• W2163173726 cites W2000204315 @default.
• W2163173726 cites W2003157753 @default.
• W2163173726 cites W2013280701 @default.
• W2163173726 cites W2022384226 @default.
• W2163173726 cites W2024797832 @default.
• W2163173726 cites W2028932253 @default.
• W2163173726 cites W2029050852 @default.
• W2163173726 cites W2038196388 @default.
• W2163173726 cites W2039736549 @default.
• W2163173726 cites W2048711451 @default.
• W2163173726 cites W2057409901 @default.
• W2163173726 cites W2069853514 @default.
• W2163173726 cites W2070766014 @default.
• W2163173726 cites W2079730244 @default.
• W2163173726 cites W2085968221 @default.
• W2163173726 cites W2102643795 @default.
• W2163173726 cites W2102751977 @default.
• W2163173726 cites W2114591228 @default.
• W2163173726 cites W2124624578 @default.
• W2163173726 cites W2131538638 @default.
• W2163173726 cites W2156711661 @default.
• W2163173726 cites W2329376611 @default.
• W2163173726 cites W2338109489 @default.
• W2163173726 cites W2404939107 @default.
• W2163173726 cites W2420710099 @default.
• W2163173726 cites W2472685179 @default.
• W2163173726 cites W250063240 @default.
• W2163173726 cites W2580707203 @default.
• W2163173726 cites W2581163053 @default.
• W2163173726 cites W3187006588 @default.
• W2163173726 doi "https://doi.org/10.1373/clinchem.2011.179929" @default.
• W2163173726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22419747" @default.
• W2163173726 hasPublicationYear "2012" @default.
• W2163173726 type Work @default.
• W2163173726 sameAs 2163173726 @default.
• W2163173726 citedByCount "36" @default.
• W2163173726 countsByYear W21631737262012 @default.
• W2163173726 countsByYear W21631737262013 @default.
• W2163173726 countsByYear W21631737262014 @default.
• W2163173726 countsByYear W21631737262015 @default.
• W2163173726 countsByYear W21631737262016 @default.
• W2163173726 countsByYear W21631737262017 @default.
• W2163173726 countsByYear W21631737262018 @default.
• W2163173726 countsByYear W21631737262020 @default.
• W2163173726 countsByYear W21631737262021 @default.
• W2163173726 countsByYear W21631737262022 @default.
• W2163173726 countsByYear W21631737262023 @default.
• W2163173726 crossrefType "journal-article" @default.
• W2163173726 hasAuthorship W2163173726A5010676456 @default.
• W2163173726 hasAuthorship W2163173726A5027294958 @default.
• W2163173726 hasAuthorship W2163173726A5029808098 @default.
• W2163173726 hasAuthorship W2163173726A5085229618 @default.
• W2163173726 hasAuthorship W2163173726A5091673364 @default.
• W2163173726 hasBestOaLocation W21631737261 @default.
• W2163173726 hasConcept C126322002 @default.
• W2163173726 hasConcept C134018914 @default.
• W2163173726 hasConcept C159654299 @default.
• W2163173726 hasConcept C185592680 @default.
• W2163173726 hasConcept C195616568 @default.
• W2163173726 hasConcept C203014093 @default.
• W2163173726 hasConcept C2776986829 @default.
• W2163173726 hasConcept C2777351272 @default.
• W2163173726 hasConcept C2779281246 @default.
• W2163173726 hasConcept C2779564779 @default.
• W2163173726 hasConcept C2781283050 @default.
• W2163173726 hasConcept C49039625 @default.
• W2163173726 hasConcept C55493867 @default.
• W2163173726 hasConcept C71924100 @default.
• W2163173726 hasConceptScore W2163173726C126322002 @default.
• W2163173726 hasConceptScore W2163173726C134018914 @default.
• W2163173726 hasConceptScore W2163173726C159654299 @default.
• W2163173726 hasConceptScore W2163173726C185592680 @default.
• W2163173726 hasConceptScore W2163173726C195616568 @default.
• W2163173726 hasConceptScore W2163173726C203014093 @default.
• W2163173726 hasConceptScore W2163173726C2776986829 @default.
• W2163173726 hasConceptScore W2163173726C2777351272 @default.
• W2163173726 hasConceptScore W2163173726C2779281246 @default.
• W2163173726 hasConceptScore W2163173726C2779564779 @default.
• W2163173726 hasConceptScore W2163173726C2781283050 @default.

• next