Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163211454> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2163211454 endingPage "1284" @default.
- W2163211454 startingPage "1280" @default.
- W2163211454 abstract "We identified eight patients with skeletal complications associated with hairy cell leukemia (HCL). The median time from diagnosis of HCL to the diagnosis of skeletal complications was 20 months (range, 0 to 93). All patients complained of pain and all but one lesion were located in the axial skeleton, primarily the proximal femur. Lytic lesions were seen on radiographic examination in all but one patient, and one patient additionally had multiple osteoporotic vertebral compression fractures. Radionuclide technetium bone scan was abnormal in all patients examined. Although the peripheral blood counts were variable (only two patients had a leukemic phase of the disease), all patients examined had a hypercellular bone marrow biopsy with hairy cells comprising at least 90% of the hematopoietic elements. The skeletal abnormalities responded well to local radiation therapy. Seven patients were begun on systemic therapy with interferon alpha-2b after the diagnosis of the skeletal lesion. Four of five evaluable patients had a partial hematological response and a substantial improvement in the degree of hairy cell infiltration of the bone marrow. None of these patients has had a recurrence of skeletal complications at a median follow-up time of 29 months. One patient failed to respond hematologically and developed additional bone lesions after 1 year of treatment. Another patient developed a new skeletal lesion 3 months after the cessation of interferon therapy at which time the bone marrow was essentially packed with hairy cells. This retrospective study indicates that bone involvement is a rare complication of HCL and is associated with a high tumor burden in the bone marrow. In addition to local radiation therapy, systemic treatment with interferon should be considered." @default.
- W2163211454 created "2016-06-24" @default.
- W2163211454 creator A5023912839 @default.
- W2163211454 creator A5027209040 @default.
- W2163211454 creator A5068268371 @default.
- W2163211454 date "1988-08-01" @default.
- W2163211454 modified "2023-10-13" @default.
- W2163211454 title "Skeletal complications in hairy cell leukemia: diagnosis and therapy." @default.
- W2163211454 cites W1488015835 @default.
- W2163211454 cites W1491555638 @default.
- W2163211454 cites W154091824 @default.
- W2163211454 cites W1879004178 @default.
- W2163211454 cites W1995752000 @default.
- W2163211454 cites W2003207351 @default.
- W2163211454 cites W2014633029 @default.
- W2163211454 cites W2041895922 @default.
- W2163211454 cites W2087445860 @default.
- W2163211454 cites W2154544412 @default.
- W2163211454 cites W2416818365 @default.
- W2163211454 cites W2417276055 @default.
- W2163211454 cites W53642436 @default.
- W2163211454 cites W88912269 @default.
- W2163211454 doi "https://doi.org/10.1200/jco.1988.6.8.1280" @default.
- W2163211454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3411340" @default.
- W2163211454 hasPublicationYear "1988" @default.
- W2163211454 type Work @default.
- W2163211454 sameAs 2163211454 @default.
- W2163211454 citedByCount "58" @default.
- W2163211454 countsByYear W21632114542013 @default.
- W2163211454 countsByYear W21632114542014 @default.
- W2163211454 countsByYear W21632114542015 @default.
- W2163211454 countsByYear W21632114542016 @default.
- W2163211454 countsByYear W21632114542017 @default.
- W2163211454 countsByYear W21632114542018 @default.
- W2163211454 countsByYear W21632114542019 @default.
- W2163211454 countsByYear W21632114542020 @default.
- W2163211454 countsByYear W21632114542022 @default.
- W2163211454 countsByYear W21632114542023 @default.
- W2163211454 crossrefType "journal-article" @default.
- W2163211454 hasAuthorship W2163211454A5023912839 @default.
- W2163211454 hasAuthorship W2163211454A5027209040 @default.
- W2163211454 hasAuthorship W2163211454A5068268371 @default.
- W2163211454 hasConcept C126838900 @default.
- W2163211454 hasConcept C141071460 @default.
- W2163211454 hasConcept C142724271 @default.
- W2163211454 hasConcept C2775934546 @default.
- W2163211454 hasConcept C2776139714 @default.
- W2163211454 hasConcept C2780007613 @default.
- W2163211454 hasConcept C2781156865 @default.
- W2163211454 hasConcept C71924100 @default.
- W2163211454 hasConcept C81182388 @default.
- W2163211454 hasConceptScore W2163211454C126838900 @default.
- W2163211454 hasConceptScore W2163211454C141071460 @default.
- W2163211454 hasConceptScore W2163211454C142724271 @default.
- W2163211454 hasConceptScore W2163211454C2775934546 @default.
- W2163211454 hasConceptScore W2163211454C2776139714 @default.
- W2163211454 hasConceptScore W2163211454C2780007613 @default.
- W2163211454 hasConceptScore W2163211454C2781156865 @default.
- W2163211454 hasConceptScore W2163211454C71924100 @default.
- W2163211454 hasConceptScore W2163211454C81182388 @default.
- W2163211454 hasIssue "8" @default.
- W2163211454 hasLocation W21632114541 @default.
- W2163211454 hasLocation W21632114542 @default.
- W2163211454 hasOpenAccess W2163211454 @default.
- W2163211454 hasPrimaryLocation W21632114541 @default.
- W2163211454 hasRelatedWork W2001448689 @default.
- W2163211454 hasRelatedWork W2030498840 @default.
- W2163211454 hasRelatedWork W2038281889 @default.
- W2163211454 hasRelatedWork W2353687582 @default.
- W2163211454 hasRelatedWork W2362105328 @default.
- W2163211454 hasRelatedWork W2377161363 @default.
- W2163211454 hasRelatedWork W2377830955 @default.
- W2163211454 hasRelatedWork W2394514052 @default.
- W2163211454 hasRelatedWork W2444171297 @default.
- W2163211454 hasRelatedWork W3054088737 @default.
- W2163211454 hasVolume "6" @default.
- W2163211454 isParatext "false" @default.
- W2163211454 isRetracted "false" @default.
- W2163211454 magId "2163211454" @default.
- W2163211454 workType "article" @default.