Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163217992> ?p ?o ?g. }
- W2163217992 endingPage "2989" @default.
- W2163217992 startingPage "2977" @default.
- W2163217992 abstract "In Schizosaccharomyces pombe, the Sty1 mitogen-activated protein kinase and the Atf1 transcription factor control transcriptional induction in response to elevated salt concentrations. Herein, we demonstrate that two repressors, Tup11 and Tup12, and the Prr1 transcription factor also function in the response to salt shock. We find that deletion of both tup genes together results in hypersensitivity to elevated cation concentrations (K + and Ca 2+ ) and we identifycta3 + , which encodes an intracellular cation transporter, as a novel stress gene whose expression is positively controlled by the Sty1 pathway and negatively regulated by Tup repressors. The expression ofcta3 + is maintained at low levels by the Tup repressors, and relief from repression requires the Sty1, Atf1, and Prr1. Prr1 is also required for KCl-mediated induction of several other Sty1-dependent genes such asgpx1 + andctt1 + . Surprisingly, the KCl-mediated induction of cta3 + expression occurs independently of Sty1 in a tup11Δ tup12Δ mutant and so the Tup repressors link induction to the Sty1 pathway. We also report that in contrast to a number of other Sty1- and Atf1-dependent genes, the expression of cta3 + is induced only by high salt concentrations. However, in the absence of the Tup repressors this specificity is lost and a range of stresses induces cta3 + expression." @default.
- W2163217992 created "2016-06-24" @default.
- W2163217992 creator A5002190691 @default.
- W2163217992 creator A5026109070 @default.
- W2163217992 creator A5030900887 @default.
- W2163217992 creator A5047440404 @default.
- W2163217992 creator A5064370058 @default.
- W2163217992 creator A5072033740 @default.
- W2163217992 creator A5084211557 @default.
- W2163217992 date "2002-09-01" @default.
- W2163217992 modified "2023-10-15" @default.
- W2163217992 title "Role of Fission Yeast Tup1-like Repressors and Prr1 Transcription Factor in Response to Salt Stress" @default.
- W2163217992 cites W1641745433 @default.
- W2163217992 cites W1724863632 @default.
- W2163217992 cites W1780581171 @default.
- W2163217992 cites W1797931385 @default.
- W2163217992 cites W1876643911 @default.
- W2163217992 cites W1889045778 @default.
- W2163217992 cites W1980224427 @default.
- W2163217992 cites W1981078475 @default.
- W2163217992 cites W1987435753 @default.
- W2163217992 cites W1990265320 @default.
- W2163217992 cites W1999162249 @default.
- W2163217992 cites W2002637675 @default.
- W2163217992 cites W2004541062 @default.
- W2163217992 cites W2006567083 @default.
- W2163217992 cites W2007625275 @default.
- W2163217992 cites W2008191493 @default.
- W2163217992 cites W2017089619 @default.
- W2163217992 cites W2018876412 @default.
- W2163217992 cites W2019797615 @default.
- W2163217992 cites W2023594830 @default.
- W2163217992 cites W2032241710 @default.
- W2163217992 cites W2032624656 @default.
- W2163217992 cites W2048983596 @default.
- W2163217992 cites W2049982108 @default.
- W2163217992 cites W2052508230 @default.
- W2163217992 cites W2068118750 @default.
- W2163217992 cites W2068689381 @default.
- W2163217992 cites W2071636295 @default.
- W2163217992 cites W2072839034 @default.
- W2163217992 cites W2075070378 @default.
- W2163217992 cites W2075819285 @default.
- W2163217992 cites W2079588007 @default.
- W2163217992 cites W2082576942 @default.
- W2163217992 cites W2091990168 @default.
- W2163217992 cites W2097843023 @default.
- W2163217992 cites W2100254469 @default.
- W2163217992 cites W2106534934 @default.
- W2163217992 cites W2111840561 @default.
- W2163217992 cites W2113576985 @default.
- W2163217992 cites W2114331520 @default.
- W2163217992 cites W2120978915 @default.
- W2163217992 cites W2121983416 @default.
- W2163217992 cites W2123155459 @default.
- W2163217992 cites W2124445103 @default.
- W2163217992 cites W2130543190 @default.
- W2163217992 cites W2131037746 @default.
- W2163217992 cites W2131977749 @default.
- W2163217992 cites W2140579027 @default.
- W2163217992 cites W2146602307 @default.
- W2163217992 cites W2146635933 @default.
- W2163217992 cites W2148680993 @default.
- W2163217992 cites W2159560490 @default.
- W2163217992 cites W2159952125 @default.
- W2163217992 cites W2194986544 @default.
- W2163217992 cites W2208680994 @default.
- W2163217992 cites W79957767 @default.
- W2163217992 doi "https://doi.org/10.1091/mbc.01-12-0568" @default.
- W2163217992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/124137" @default.
- W2163217992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12221110" @default.
- W2163217992 hasPublicationYear "2002" @default.
- W2163217992 type Work @default.
- W2163217992 sameAs 2163217992 @default.
- W2163217992 citedByCount "42" @default.
- W2163217992 countsByYear W21632179922012 @default.
- W2163217992 countsByYear W21632179922013 @default.
- W2163217992 countsByYear W21632179922014 @default.
- W2163217992 countsByYear W21632179922015 @default.
- W2163217992 countsByYear W21632179922016 @default.
- W2163217992 countsByYear W21632179922017 @default.
- W2163217992 countsByYear W21632179922020 @default.
- W2163217992 countsByYear W21632179922021 @default.
- W2163217992 crossrefType "journal-article" @default.
- W2163217992 hasAuthorship W2163217992A5002190691 @default.
- W2163217992 hasAuthorship W2163217992A5026109070 @default.
- W2163217992 hasAuthorship W2163217992A5030900887 @default.
- W2163217992 hasAuthorship W2163217992A5047440404 @default.
- W2163217992 hasAuthorship W2163217992A5064370058 @default.
- W2163217992 hasAuthorship W2163217992A5072033740 @default.
- W2163217992 hasAuthorship W2163217992A5084211557 @default.
- W2163217992 hasBestOaLocation W21632179922 @default.
- W2163217992 hasConcept C104317684 @default.
- W2163217992 hasConcept C143065580 @default.
- W2163217992 hasConcept C150194340 @default.
- W2163217992 hasConcept C158448853 @default.
- W2163217992 hasConcept C162317418 @default.
- W2163217992 hasConcept C165864922 @default.