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- W2163218983 abstract "A major goal of asthma management is maintaining optimal control. Current assessment is based on symptoms and lung function. We evaluated whether domiciliary daily home exhaled nitric oxide fraction (<i>F</i><sub>eNO</sub>) monitoring could be useful as an index of asthma control. 50 asthmatic subjects and 15 healthy volunteers with a range of asthma severity underwent asthma control questionnaire (ACQ), spirometry before and after salbutamol and sputum induction. <i>F</i><sub>eNO</sub> and peak expiratory flow (PEF) were measured twice daily for 2 weeks. A record of exacerbations was obtained 3 months later. Diurnal <i>F</i><sub>eNO</sub> variation in uncontrolled asthmatics was significantly greater than in controlled asthmatics (p<0.01). PEF variation was not different. The daily variation of <i>F</i><sub>eNO</sub> levels was also greater in uncontrolled asthmatics compared with controlled asthmatic and healthy subjects (p<0.01). 80% of uncontrolled asthmatics experienced at least one or more exacerbations over the 3 months after the enrolment. The combination of diurnal <i>F</i><sub>eNO</sub> variation ≥16.6% and ACQ scores ≥1.8 was best at predicting uncontrolled asthma (area under curve 0.91, 95% CI 0.86–0.97; p<0.001). Diurnal variation in <i>F</i><sub>eNO</sub> can be used as a biomarker of asthma control and as a predictor of the risk of future exacerbation. Prospective studies are warranted." @default.
- W2163218983 created "2016-06-24" @default.
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- W2163218983 date "2013-08-15" @default.
- W2163218983 modified "2023-10-18" @default.
- W2163218983 title "Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control" @default.
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- W2163218983 doi "https://doi.org/10.1183/09031936.00048513" @default.
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