FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163220561> ?p ?o ?g. }

• W2163220561 endingPage "R122" @default.
• W2163220561 startingPage "R122" @default.
• W2163220561 abstract "X chromosome inactivation is a spectacular example of epigenetic silencing. In order to deduce how this complex system evolved, we examined X inactivation in a model marsupial, the tammar wallaby (Macropus eugenii). In marsupials, X inactivation is known to be paternal, incomplete and tissue-specific, and occurs in the absence of an XIST orthologue.We examined expression of X-borne genes using quantitative PCR, revealing a range of dosage compensation for different loci. To assess the frequency of 1X- or 2X-active fibroblasts, we investigated expression of 32 X-borne genes at the cellular level using RNA-FISH. In female fibroblasts, two-color RNA-FISH showed that genes were coordinately expressed from the same X (active X) in nuclei in which both loci were inactivated. However, loci on the other X escape inactivation independently, with each locus showing a characteristic frequency of 1X-active and 2X-active nuclei, equivalent to stochastic escape. We constructed an activity map of the tammar wallaby inactive X chromosome, which identified no relationship between gene location and extent of inactivation, nor any correlation with the presence or absence of a Y-borne paralog.In the tammar wallaby, one X (presumed to be maternal) is expressed in all cells, but genes on the other (paternal) X escape inactivation independently and at characteristic frequencies. The paternal and incomplete X chromosome inactivation in marsupials, with stochastic escape, appears to be quite distinct from the X chromosome inactivation process in eutherians. We find no evidence for a polar spread of inactivation from an X inactivation center." @default.
• W2163220561 created "2016-06-24" @default.
• W2163220561 creator A5003786277 @default.
• W2163220561 creator A5017287058 @default.
• W2163220561 creator A5027020134 @default.
• W2163220561 creator A5034070636 @default.
• W2163220561 creator A5078493290 @default.
• W2163220561 creator A5089371380 @default.
• W2163220561 date "2010-01-01" @default.
• W2163220561 modified "2023-09-26" @default.
• W2163220561 title "Activity map of the tammar X chromosome shows that marsupial X inactivation is incomplete and escape is stochastic" @default.
• W2163220561 cites W1526580148 @default.
• W2163220561 cites W1530923143 @default.
• W2163220561 cites W1549656943 @default.
• W2163220561 cites W1688631023 @default.
• W2163220561 cites W1832684233 @default.
• W2163220561 cites W1973604949 @default.
• W2163220561 cites W1977364126 @default.
• W2163220561 cites W1977541555 @default.
• W2163220561 cites W1985437206 @default.
• W2163220561 cites W1994084343 @default.
• W2163220561 cites W1996309079 @default.
• W2163220561 cites W1997153406 @default.
• W2163220561 cites W1997528909 @default.
• W2163220561 cites W1998418275 @default.
• W2163220561 cites W2000257726 @default.
• W2163220561 cites W2002758933 @default.
• W2163220561 cites W2014143877 @default.
• W2163220561 cites W2014377267 @default.
• W2163220561 cites W2020958409 @default.
• W2163220561 cites W2021122622 @default.
• W2163220561 cites W2023106749 @default.
• W2163220561 cites W2027302349 @default.
• W2163220561 cites W2034726926 @default.
• W2163220561 cites W2045847497 @default.
• W2163220561 cites W2046990885 @default.
• W2163220561 cites W2050255721 @default.
• W2163220561 cites W2052294617 @default.
• W2163220561 cites W2068348896 @default.
• W2163220561 cites W2075458954 @default.
• W2163220561 cites W2077252970 @default.
• W2163220561 cites W2079597045 @default.
• W2163220561 cites W2082258424 @default.
• W2163220561 cites W2082321335 @default.
• W2163220561 cites W2083383771 @default.
• W2163220561 cites W2087687290 @default.
• W2163220561 cites W2089550096 @default.
• W2163220561 cites W2093466316 @default.
• W2163220561 cites W2094646764 @default.
• W2163220561 cites W2106027559 @default.
• W2163220561 cites W2112455395 @default.
• W2163220561 cites W2127600364 @default.
• W2163220561 cites W2137407610 @default.
• W2163220561 cites W2137911557 @default.
• W2163220561 cites W2142135333 @default.
• W2163220561 cites W2144670999 @default.
• W2163220561 cites W2153741444 @default.
• W2163220561 cites W2157457551 @default.
• W2163220561 cites W2162716521 @default.
• W2163220561 cites W2408377479 @default.
• W2163220561 cites W2462016234 @default.
• W2163220561 cites W59760523 @default.
• W2163220561 doi "https://doi.org/10.1186/gb-2010-11-12-r122" @default.
• W2163220561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3046482" @default.
• W2163220561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21182760" @default.
• W2163220561 hasPublicationYear "2010" @default.
• W2163220561 type Work @default.
• W2163220561 sameAs 2163220561 @default.
• W2163220561 citedByCount "45" @default.
• W2163220561 countsByYear W21632205612012 @default.
• W2163220561 countsByYear W21632205612013 @default.
• W2163220561 countsByYear W21632205612014 @default.
• W2163220561 countsByYear W21632205612015 @default.
• W2163220561 countsByYear W21632205612016 @default.
• W2163220561 countsByYear W21632205612017 @default.
• W2163220561 countsByYear W21632205612018 @default.
• W2163220561 countsByYear W21632205612019 @default.
• W2163220561 countsByYear W21632205612021 @default.
• W2163220561 countsByYear W21632205612022 @default.
• W2163220561 crossrefType "journal-article" @default.
• W2163220561 hasAuthorship W2163220561A5003786277 @default.
• W2163220561 hasAuthorship W2163220561A5017287058 @default.
• W2163220561 hasAuthorship W2163220561A5027020134 @default.
• W2163220561 hasAuthorship W2163220561A5034070636 @default.
• W2163220561 hasAuthorship W2163220561A5078493290 @default.
• W2163220561 hasAuthorship W2163220561A5089371380 @default.
• W2163220561 hasBestOaLocation W21632205611 @default.
• W2163220561 hasConcept C104317684 @default.
• W2163220561 hasConcept C110411900 @default.
• W2163220561 hasConcept C151730666 @default.
• W2163220561 hasConcept C153911025 @default.
• W2163220561 hasConcept C2590687 @default.
• W2163220561 hasConcept C2777042810 @default.
• W2163220561 hasConcept C2779970363 @default.
• W2163220561 hasConcept C2910561697 @default.
• W2163220561 hasConcept C30481170 @default.
• W2163220561 hasConcept C35158069 @default.
• W2163220561 hasConcept C4323932 @default.

• next