FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163234342> ?p ?o ?g. }

• W2163234342 endingPage "570" @default.
• W2163234342 startingPage "561" @default.
• W2163234342 abstract "Background: As a major source of indoor allergens, cockroach causes perennial rhinitis and asthma. Recently, cockroach feces were reported to contain TLR2 agonist, which could directly activate neutrophils to release cytokines. CpG oligodeoxynucleotide (ODN), a Toll-like receptor (TLR)9 activator was also found to induce proinflammatory cytokine release from mast cells. However, influence of specific cockroach allergen on Th1 cytokine release and expression of TLR9 in mast cells remains uninvestigated. Methods: To investigate effects of Per a 7 on TLR expression and cytokine release from mast cells and their cell signaling mechanisms, P815 cells were challenged by recombinant Per a 7 (rPer a 7), and expression of TLR9 mRNA and protein was assessed mainly by real time PCR and flow cytometry analysis. Detection of phosphorylation of cell signaling components was performed with Western blotting technique. Results: The results showed that rPer a 7 induced up to 72 and 46% down-regulation of expression of TLR9 mRNA and protein, respectively following 16 h incubation period. It induced also approximately 41.1% reduction of IL-12 release. When PD98059, U0126 and LY294002 were pre-incubated with the cells for 30 min they diminished rPer a 7 induced reduction of TLR9 expression and IL-12 release, indicating these events are via activation of ERK and PI3K/Akt signaling pathways. Conclusion: Reduction of IL-12 production and expression of TLR9 in P815 mastocytoma cells by Per a 7 suggests that this major cockroach allergen might contribute to the development of cockroach allergy." @default.
• W2163234342 created "2016-06-24" @default.
• W2163234342 creator A5003799076 @default.
• W2163234342 creator A5014758525 @default.
• W2163234342 creator A5043192495 @default.
• W2163234342 creator A5057286088 @default.
• W2163234342 creator A5064024990 @default.
• W2163234342 creator A5073510977 @default.
• W2163234342 creator A5076855467 @default.
• W2163234342 creator A5081254368 @default.
• W2163234342 date "2012-01-01" @default.
• W2163234342 modified "2023-10-11" @default.
• W2163234342 title "Cockroach Allergen per a 7 Down-Regulates Expression of Toll-Like Receptor 9 and IL-12 Release from P815 Cells Through PI3K and MAPK Signaling Pathways" @default.
• W2163234342 cites W1528203757 @default.
• W2163234342 cites W1583081002 @default.
• W2163234342 cites W1583545752 @default.
• W2163234342 cites W1991356909 @default.
• W2163234342 cites W2001818308 @default.
• W2163234342 cites W2002361100 @default.
• W2163234342 cites W2004135191 @default.
• W2163234342 cites W2012087111 @default.
• W2163234342 cites W2012409787 @default.
• W2163234342 cites W2021659405 @default.
• W2163234342 cites W2039183202 @default.
• W2163234342 cites W2041048225 @default.
• W2163234342 cites W2046212128 @default.
• W2163234342 cites W2052525222 @default.
• W2163234342 cites W2052887890 @default.
• W2163234342 cites W2054187056 @default.
• W2163234342 cites W2074225978 @default.
• W2163234342 cites W2074589994 @default.
• W2163234342 cites W2076219754 @default.
• W2163234342 cites W2079107138 @default.
• W2163234342 cites W2079111307 @default.
• W2163234342 cites W2082855286 @default.
• W2163234342 cites W2085624690 @default.
• W2163234342 cites W2095042157 @default.
• W2163234342 cites W2098526169 @default.
• W2163234342 cites W2129259619 @default.
• W2163234342 cites W2131567916 @default.
• W2163234342 cites W2138686669 @default.
• W2163234342 cites W2143376934 @default.
• W2163234342 cites W2151175761 @default.
• W2163234342 cites W2161938158 @default.
• W2163234342 cites W2397048678 @default.
• W2163234342 cites W2416705559 @default.
• W2163234342 cites W289046778 @default.
• W2163234342 doi "https://doi.org/10.1159/000338510" @default.
• W2163234342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22508063" @default.
• W2163234342 hasPublicationYear "2012" @default.
• W2163234342 type Work @default.
• W2163234342 sameAs 2163234342 @default.
• W2163234342 citedByCount "16" @default.
• W2163234342 countsByYear W21632343422013 @default.
• W2163234342 countsByYear W21632343422014 @default.
• W2163234342 countsByYear W21632343422015 @default.
• W2163234342 countsByYear W21632343422016 @default.
• W2163234342 countsByYear W21632343422017 @default.
• W2163234342 countsByYear W21632343422018 @default.
• W2163234342 countsByYear W21632343422019 @default.
• W2163234342 countsByYear W21632343422021 @default.
• W2163234342 crossrefType "journal-article" @default.
• W2163234342 hasAuthorship W2163234342A5003799076 @default.
• W2163234342 hasAuthorship W2163234342A5014758525 @default.
• W2163234342 hasAuthorship W2163234342A5043192495 @default.
• W2163234342 hasAuthorship W2163234342A5057286088 @default.
• W2163234342 hasAuthorship W2163234342A5064024990 @default.
• W2163234342 hasAuthorship W2163234342A5073510977 @default.
• W2163234342 hasAuthorship W2163234342A5076855467 @default.
• W2163234342 hasAuthorship W2163234342A5081254368 @default.
• W2163234342 hasBestOaLocation W21632343421 @default.
• W2163234342 hasConcept C104317684 @default.
• W2163234342 hasConcept C150194340 @default.
• W2163234342 hasConcept C153911025 @default.
• W2163234342 hasConcept C185592680 @default.
• W2163234342 hasConcept C190727270 @default.
• W2163234342 hasConcept C203014093 @default.
• W2163234342 hasConcept C2776070231 @default.
• W2163234342 hasConcept C2778690821 @default.
• W2163234342 hasConcept C2779138994 @default.
• W2163234342 hasConcept C2779726688 @default.
• W2163234342 hasConcept C2781236682 @default.
• W2163234342 hasConcept C55493867 @default.
• W2163234342 hasConcept C57074206 @default.
• W2163234342 hasConcept C62478195 @default.
• W2163234342 hasConcept C86803240 @default.
• W2163234342 hasConcept C95444343 @default.
• W2163234342 hasConceptScore W2163234342C104317684 @default.
• W2163234342 hasConceptScore W2163234342C150194340 @default.
• W2163234342 hasConceptScore W2163234342C153911025 @default.
• W2163234342 hasConceptScore W2163234342C185592680 @default.
• W2163234342 hasConceptScore W2163234342C190727270 @default.
• W2163234342 hasConceptScore W2163234342C203014093 @default.
• W2163234342 hasConceptScore W2163234342C2776070231 @default.
• W2163234342 hasConceptScore W2163234342C2778690821 @default.
• W2163234342 hasConceptScore W2163234342C2779138994 @default.
• W2163234342 hasConceptScore W2163234342C2779726688 @default.
• W2163234342 hasConceptScore W2163234342C2781236682 @default.

• next