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- W2163240675 abstract "<b>Background:</b> Pulmonary hypertension (PH) and right heart failure are common complications of COPD. Its presence is associated with shorter survival and worse clinical outcome. Vasodilators are supposed to reduce PH and improve cardiac function. <b>Aim:</b> To study the hemodynamic effects and wsafety of the use of Angiotensin II receptor blockers (ARBs) inhibitor Valsartan in secondary PH in patients with COPD. <b>Material and methods:</b> The study included 40 patients (mean age 45.0±2.0 years) with stable COPD and secondary PH, divided into 2 groups, comparable by age, sex, duration and stage of the disease. Patients in group 1 (n=20), administered Valsartan 82,6+3,1 mg/day for 6 weeks on the background of treatment with bronchodilators (Beta2-agonists). Patients in group 2 (n=20) received only treatment with bronchodilators (Beta2-agonists) for 6 weeks. <b>Results:</b> The applied treatment with Valsartan decreased the pulmonary arterial pressure by 17.2% (p<0.01), and treatment without Valsartan – by 9.2±1.0% (p<0.05). These changes are explained by the decrease in pulmonary vascular resistance by 15.4% (p<0.01) and 8.2% (p<0.05), respectively. The cardiac index in both groups has not changed reliably. An important aspect of Valsartan was its good tolerability. <b>Conclusion:</b> The use of the ARB Valsartan in the treatment of patients with COPD complicated by PH have the ability to improve pulmonary hemodynamics. The drug is well tolerated by patients." @default.
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- W2163240675 date "2010-11-08" @default.
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- W2163240675 title "Chiari I malformation manifesting as bilateral trigeminal neuralgia: case report and review of the literature" @default.
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- W2163240675 doi "https://doi.org/10.1136/jnnp.2009.196121" @default.
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