FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163249181> ?p ?o ?g. }

• W2163249181 endingPage "289" @default.
• W2163249181 startingPage "282" @default.
• W2163249181 abstract "BACKGROUND: Clear cell renal cell carcinoma (CRCC) is the most common malignant tumor of the kidney, and the clinical outcome of CRCC is related with the metastatic potential of CRCC. A significant proportion of metastatic CRCC remains incurable. Recently, immunotherapy against specific targets such as programmed death 1 (PD1) has been adapted for fatal cases of CRCC. MATERIALS AND METHODS: In this study, we aimed to evaluate the potential of tumor-infiltrating PD1-positive lymphocytes or FoxP3-positive regulatory T cells (Tregs) as predictors of the metastatic potential or prognosis of CRCC and investigate possible correlations with Epstein-Barr virus (EBV) infection in 199 cases of CRCC. RESULTS: PD1 positivity, high Treg number, and EBV infection all predicted poor overall survival (OS) by univariate analysis. PD1 positivity and high Treg numbers were also significantly correlated with more distant metastatic relapse (DMR) and poor relapse-free survival (RFS) by univariate analysis. PD1 positivity and high Treg number were independent prognostic indicators for OS. In addition, PD1 positivity was an independent predictor of RFS and DMR. EBV infection was an independent predictor of OS of CRCC. CONCLUSION: This study demonstrates that intratumoral infiltration of PD1-positive or FoxP3-positive lymphocytes can be used as significant prognostic indicators of CRCC and PD1 positivity could be very helpful in the prediction of latent distant metastasis of CRCCs. Therefore, evaluation of the infiltration of PD-positive cells or Tregs in CRCC may be useful diagnostic tools for the selection of patients who could benefit from PD1- or Treg-based immunotherapy." @default.
• W2163249181 created "2016-06-24" @default.
• W2163249181 creator A5010013118 @default.
• W2163249181 creator A5011015630 @default.
• W2163249181 creator A5017399924 @default.
• W2163249181 creator A5035052396 @default.
• W2163249181 creator A5047052048 @default.
• W2163249181 creator A5057044012 @default.
• W2163249181 creator A5065911154 @default.
• W2163249181 creator A5072357420 @default.
• W2163249181 creator A5085443770 @default.
• W2163249181 date "2013-06-01" @default.
• W2163249181 modified "2023-10-01" @default.
• W2163249181 title "Tumor-infiltrating PD1-Positive Lymphocytes and FoxP3-Positive Regulatory T Cells Predict Distant Metastatic Relapse and Survival of Clear Cell Renal Cell Carcinoma" @default.
• W2163249181 cites W1972545311 @default.
• W2163249181 cites W1984393957 @default.
• W2163249181 cites W1986816666 @default.
• W2163249181 cites W1991598164 @default.
• W2163249181 cites W1994903218 @default.
• W2163249181 cites W2032838951 @default.
• W2163249181 cites W2034190600 @default.
• W2163249181 cites W2036029957 @default.
• W2163249181 cites W2036240115 @default.
• W2163249181 cites W2039545078 @default.
• W2163249181 cites W2040164466 @default.
• W2163249181 cites W2041881143 @default.
• W2163249181 cites W2066825713 @default.
• W2163249181 cites W2067096807 @default.
• W2163249181 cites W2069738382 @default.
• W2163249181 cites W2071386962 @default.
• W2163249181 cites W2071478196 @default.
• W2163249181 cites W2084536063 @default.
• W2163249181 cites W2087246109 @default.
• W2163249181 cites W2098983864 @default.
• W2163249181 cites W2100001853 @default.
• W2163249181 cites W2100006379 @default.
• W2163249181 cites W2102575291 @default.
• W2163249181 cites W2107752337 @default.
• W2163249181 cites W2118471749 @default.
• W2163249181 cites W2123424099 @default.
• W2163249181 cites W2124095998 @default.
• W2163249181 cites W2135139265 @default.
• W2163249181 cites W2135737755 @default.
• W2163249181 cites W2138082498 @default.
• W2163249181 cites W2140633375 @default.
• W2163249181 cites W2160380981 @default.
• W2163249181 cites W2160834915 @default.
• W2163249181 cites W2168069492 @default.
• W2163249181 cites W2560382827 @default.
• W2163249181 doi "https://doi.org/10.1593/tlo.13256" @default.
• W2163249181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3660796" @default.
• W2163249181 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23730407" @default.
• W2163249181 hasPublicationYear "2013" @default.
• W2163249181 type Work @default.
• W2163249181 sameAs 2163249181 @default.
• W2163249181 citedByCount "101" @default.
• W2163249181 countsByYear W21632491812013 @default.
• W2163249181 countsByYear W21632491812014 @default.
• W2163249181 countsByYear W21632491812015 @default.
• W2163249181 countsByYear W21632491812016 @default.
• W2163249181 countsByYear W21632491812017 @default.
• W2163249181 countsByYear W21632491812018 @default.
• W2163249181 countsByYear W21632491812019 @default.
• W2163249181 countsByYear W21632491812020 @default.
• W2163249181 countsByYear W21632491812021 @default.
• W2163249181 countsByYear W21632491812022 @default.
• W2163249181 countsByYear W21632491812023 @default.
• W2163249181 crossrefType "journal-article" @default.
• W2163249181 hasAuthorship W2163249181A5010013118 @default.
• W2163249181 hasAuthorship W2163249181A5011015630 @default.
• W2163249181 hasAuthorship W2163249181A5017399924 @default.
• W2163249181 hasAuthorship W2163249181A5035052396 @default.
• W2163249181 hasAuthorship W2163249181A5047052048 @default.
• W2163249181 hasAuthorship W2163249181A5057044012 @default.
• W2163249181 hasAuthorship W2163249181A5065911154 @default.
• W2163249181 hasAuthorship W2163249181A5072357420 @default.
• W2163249181 hasAuthorship W2163249181A5085443770 @default.
• W2163249181 hasBestOaLocation W21632491811 @default.
• W2163249181 hasConcept C105795698 @default.
• W2163249181 hasConcept C121608353 @default.
• W2163249181 hasConcept C126322002 @default.
• W2163249181 hasConcept C143998085 @default.
• W2163249181 hasConcept C144301174 @default.
• W2163249181 hasConcept C161584116 @default.
• W2163249181 hasConcept C199163554 @default.
• W2163249181 hasConcept C203014093 @default.
• W2163249181 hasConcept C2777472916 @default.
• W2163249181 hasConcept C2777701055 @default.
• W2163249181 hasConcept C2779013556 @default.
• W2163249181 hasConcept C2779727006 @default.
• W2163249181 hasConcept C2781278892 @default.
• W2163249181 hasConcept C3019926457 @default.
• W2163249181 hasConcept C33923547 @default.
• W2163249181 hasConcept C38180746 @default.
• W2163249181 hasConcept C71924100 @default.
• W2163249181 hasConcept C8891405 @default.
• W2163249181 hasConceptScore W2163249181C105795698 @default.
• W2163249181 hasConceptScore W2163249181C121608353 @default.

• next