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- W2163267311 abstract "During the germinal center (GC) reaction a characteristic morphology is developed. In the framework of a recently developed space‐time model for the GC, a mechanism for the formation of dark and light zones has been proposed. There, the mechanism is based on a diffusing differentiation signal which is distinguished by follicular dendritic cells (FDC). Here, we investigate a possible influence of recently found chemoattractants on GC formation in the framework of a single cell‐based stochastic and discrete three‐dimensional model. This necessitates a more detailed spatial description. The model is enlarged by a detailed prescription of cell motility and it is introduced as a consistent volume concept. We consider various possible chemotactic pathways that may play a role for the development of both zones. Our results suggest that the centrocyte motility resulting from a FDC‐derived chemoattractant has to exceed a lower limit to allow the separation of centroblasts and centrocytes. In contrast to light microscopy, the dark zone is ring shaped. This suggests that FDC‐derived chemoattractants alone cannot explain the typical GC morphology." @default.
- W2163267311 created "2016-06-24" @default.
- W2163267311 creator A5004795664 @default.
- W2163267311 creator A5024162635 @default.
- W2163267311 creator A5061447095 @default.
- W2163267311 date "2002-12-01" @default.
- W2163267311 modified "2023-10-17" @default.
- W2163267311 title "A possible role of chemotaxis in germinal center formation" @default.
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- W2163267311 doi "https://doi.org/10.1093/intimm/dxf104" @default.
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