FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163275841> ?p ?o ?g. }

• W2163275841 endingPage "206" @default.
• W2163275841 startingPage "197" @default.
• W2163275841 abstract "AimThe aim of the current study is to detect CTCs in the blood of breast cancer females by the expression of Mammoglobin and Mucin-1 to evaluate their potential as diagnostic and prognostic markers of breast cancer and predictors of metastasis.Subjects and methodsThe study involved 50 patients and thirty controls. Fifty patients recently diagnosed with breast cancer were proved by fine needle aspiration cytology or core biopsy, all the patients were operated upon by modified radical mastectomy under general anesthesia after complete preoperative evaluation. From each subject a blood sample was drawn before surgery, 2 weeks after surgery and after 6 cycles of chemotherapy. Mononuclear cells were separated from 7.5 ml blood using a phicoll gradient. From these cells mRNA was extracted, and RT-PCR was carried out to detect Mammoglobin and Mucin-1 gene expression from CTCs. Also CA 15.3 was measured in all the samples.ResultsCTCs were detected in more than 80% of primary breast cancer patients at presentation, that percent decreased after surgery and after adjuvant chemotherapy. CTCs detection after surgery and after chemotherapy was significantly correlated with tumor size, grad, vascular invasion and metastasis. CTCs posed an almost two-fold risk of metastasis and significantly lower DFS time in positive than in negative patients. Detection of CTCs in peripheral blood after chemotherapy successfully predicted subsequent metastasis.ConclusionThe hematogenous spread of tumor cells in patients with breast cancer may be an early phenomenon occurring before/apart from regional lymph nodes involvement. CTCs detection by RT-PCR could add to the initial evaluation of primary breast cancer patients. Also, adjuvant chemotherapy might eliminate or decrease occult tumor cells. But CTCs evaluation after adjuvant chemotherapy could predict metastasis and the presence of CTCs after chemotherapy reflect a higher potential for subsequent metastasis." @default.
• W2163275841 created "2016-06-24" @default.
• W2163275841 creator A5030952720 @default.
• W2163275841 creator A5047280854 @default.
• W2163275841 creator A5052850744 @default.
• W2163275841 creator A5085521247 @default.
• W2163275841 creator A5086220005 @default.
• W2163275841 creator A5089961662 @default.
• W2163275841 date "2012-09-01" @default.
• W2163275841 modified "2023-10-17" @default.
• W2163275841 title "Diagnostic and prognostic value of circulating tumor cells in female breast cancer patients" @default.
• W2163275841 cites W1763403270 @default.
• W2163275841 cites W1977075517 @default.
• W2163275841 cites W1986993149 @default.
• W2163275841 cites W1992285691 @default.
• W2163275841 cites W1996302215 @default.
• W2163275841 cites W1998050847 @default.
• W2163275841 cites W2004280628 @default.
• W2163275841 cites W2004781757 @default.
• W2163275841 cites W2007897263 @default.
• W2163275841 cites W2008628225 @default.
• W2163275841 cites W2013972195 @default.
• W2163275841 cites W2018520048 @default.
• W2163275841 cites W2020566477 @default.
• W2163275841 cites W2029842043 @default.
• W2163275841 cites W2035149893 @default.
• W2163275841 cites W2037547770 @default.
• W2163275841 cites W2043041181 @default.
• W2163275841 cites W2043103956 @default.
• W2163275841 cites W2053059448 @default.
• W2163275841 cites W2066217297 @default.
• W2163275841 cites W2067279821 @default.
• W2163275841 cites W2070291618 @default.
• W2163275841 cites W2080244053 @default.
• W2163275841 cites W2090280322 @default.
• W2163275841 cites W2090424555 @default.
• W2163275841 cites W2102806463 @default.
• W2163275841 cites W2106181914 @default.
• W2163275841 cites W2116388783 @default.
• W2163275841 cites W2121672045 @default.
• W2163275841 cites W2122588125 @default.
• W2163275841 cites W2123259832 @default.
• W2163275841 cites W2146050250 @default.
• W2163275841 cites W2150312232 @default.
• W2163275841 cites W2150832968 @default.
• W2163275841 cites W2152835558 @default.
• W2163275841 cites W2170481258 @default.
• W2163275841 doi "https://doi.org/10.1016/j.ajme.2012.02.005" @default.
• W2163275841 hasPublicationYear "2012" @default.
• W2163275841 type Work @default.
• W2163275841 sameAs 2163275841 @default.
• W2163275841 citedByCount "4" @default.
• W2163275841 countsByYear W21632758412014 @default.
• W2163275841 countsByYear W21632758412019 @default.
• W2163275841 countsByYear W21632758412020 @default.
• W2163275841 crossrefType "journal-article" @default.
• W2163275841 hasAuthorship W2163275841A5030952720 @default.
• W2163275841 hasAuthorship W2163275841A5047280854 @default.
• W2163275841 hasAuthorship W2163275841A5052850744 @default.
• W2163275841 hasAuthorship W2163275841A5085521247 @default.
• W2163275841 hasAuthorship W2163275841A5086220005 @default.
• W2163275841 hasAuthorship W2163275841A5089961662 @default.
• W2163275841 hasBestOaLocation W21632758411 @default.
• W2163275841 hasConcept C118646709 @default.
• W2163275841 hasConcept C121608353 @default.
• W2163275841 hasConcept C126322002 @default.
• W2163275841 hasConcept C142724271 @default.
• W2163275841 hasConcept C143998085 @default.
• W2163275841 hasConcept C2775934546 @default.
• W2163275841 hasConcept C2776694085 @default.
• W2163275841 hasConcept C2779013556 @default.
• W2163275841 hasConcept C530470458 @default.
• W2163275841 hasConcept C61238886 @default.
• W2163275841 hasConcept C71924100 @default.
• W2163275841 hasConceptScore W2163275841C118646709 @default.
• W2163275841 hasConceptScore W2163275841C121608353 @default.
• W2163275841 hasConceptScore W2163275841C126322002 @default.
• W2163275841 hasConceptScore W2163275841C142724271 @default.
• W2163275841 hasConceptScore W2163275841C143998085 @default.
• W2163275841 hasConceptScore W2163275841C2775934546 @default.
• W2163275841 hasConceptScore W2163275841C2776694085 @default.
• W2163275841 hasConceptScore W2163275841C2779013556 @default.
• W2163275841 hasConceptScore W2163275841C530470458 @default.
• W2163275841 hasConceptScore W2163275841C61238886 @default.
• W2163275841 hasConceptScore W2163275841C71924100 @default.
• W2163275841 hasIssue "3" @default.
• W2163275841 hasLocation W21632758411 @default.
• W2163275841 hasOpenAccess W2163275841 @default.
• W2163275841 hasPrimaryLocation W21632758411 @default.
• W2163275841 hasRelatedWork W2144318661 @default.
• W2163275841 hasRelatedWork W2378034344 @default.
• W2163275841 hasRelatedWork W2383305151 @default.
• W2163275841 hasRelatedWork W2395906155 @default.
• W2163275841 hasRelatedWork W2534174115 @default.
• W2163275841 hasRelatedWork W2979892935 @default.
• W2163275841 hasRelatedWork W3033874287 @default.
• W2163275841 hasRelatedWork W3088410393 @default.
• W2163275841 hasRelatedWork W377899687 @default.

• next