Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163283982> ?p ?o ?g. }
- W2163283982 endingPage "23" @default.
- W2163283982 startingPage "2" @default.
- W2163283982 abstract "Glucuronidation is a major drug-metabolizing reaction in humans. A pharmacological effect of glucuronide metabolites is frequently neglected and the value of therapeutic drug monitoring has been questioned. However, this may not always be true.In this review the impact of glucuronidation on therapeutic drug monitoring has been evaluated on the basis of a literature search and experience from the own laboratory.The potential role of monitoring glucuronide metabolite concentrations to optimize therapeutic outcome is addressed on the basis of selected examples of drugs which are metabolized to biologically active/reactive glucuronides. Furthermore indirect effects of glucuronide metabolites on parent drug pharmacokinetics are presented. In addition, factors that may modulate the disposition of these metabolites (e.g. genetic polymorphisms, disease processes, age, and drug-drug interactions) are briefly mentioned and their relevance for the clinical situation is critically discussed.Glucuronide metabolites can have indirect as well as direct pharmacological or toxicological effects. Although convincing evidence to support the introduction of glucuronide monitoring into clinical practice is currently missing, measurement of glucuronide concentrations may be advantageous in specific situations. If the glucuronide metabolite has an indirect effect on the pharmacokinetics of the parent compound, monitoring of the parent drug may be considered. Furthermore pharmacogenetic approaches considering uridine diphosphate (UDP) glucuronosyltransferases polymorphisms may become useful in the future to optimize therapy with drugs subject to glucuronidation." @default.
- W2163283982 created "2016-06-24" @default.
- W2163283982 creator A5045318721 @default.
- W2163283982 creator A5089500425 @default.
- W2163283982 date "2005-08-01" @default.
- W2163283982 modified "2023-10-14" @default.
- W2163283982 title "Glucuronidation in therapeutic drug monitoring" @default.
- W2163283982 cites W109729941 @default.
- W2163283982 cites W112904234 @default.
- W2163283982 cites W172975866 @default.
- W2163283982 cites W1805386838 @default.
- W2163283982 cites W1935266807 @default.
- W2163283982 cites W1941314279 @default.
- W2163283982 cites W1966265764 @default.
- W2163283982 cites W1967299205 @default.
- W2163283982 cites W1968663016 @default.
- W2163283982 cites W1968788255 @default.
- W2163283982 cites W1968874980 @default.
- W2163283982 cites W1970520180 @default.
- W2163283982 cites W1970655614 @default.
- W2163283982 cites W1972099913 @default.
- W2163283982 cites W1973148360 @default.
- W2163283982 cites W1973426823 @default.
- W2163283982 cites W1979095679 @default.
- W2163283982 cites W1982058771 @default.
- W2163283982 cites W1982176799 @default.
- W2163283982 cites W1983989974 @default.
- W2163283982 cites W1984493791 @default.
- W2163283982 cites W1985334643 @default.
- W2163283982 cites W1985732783 @default.
- W2163283982 cites W1985750268 @default.
- W2163283982 cites W1985846963 @default.
- W2163283982 cites W1986362943 @default.
- W2163283982 cites W1986412179 @default.
- W2163283982 cites W1987198534 @default.
- W2163283982 cites W1989710977 @default.
- W2163283982 cites W1995116750 @default.
- W2163283982 cites W1997401353 @default.
- W2163283982 cites W2001665244 @default.
- W2163283982 cites W2002387779 @default.
- W2163283982 cites W2004250621 @default.
- W2163283982 cites W2005769122 @default.
- W2163283982 cites W2006419324 @default.
- W2163283982 cites W2006908055 @default.
- W2163283982 cites W2008932274 @default.
- W2163283982 cites W2010110346 @default.
- W2163283982 cites W2010436911 @default.
- W2163283982 cites W2011738314 @default.
- W2163283982 cites W2011780463 @default.
- W2163283982 cites W2016100084 @default.
- W2163283982 cites W2016335393 @default.
- W2163283982 cites W2016458207 @default.
- W2163283982 cites W2016527473 @default.
- W2163283982 cites W2017010426 @default.
- W2163283982 cites W2018988859 @default.
- W2163283982 cites W2019411938 @default.
- W2163283982 cites W2019950093 @default.
- W2163283982 cites W2020104576 @default.
- W2163283982 cites W2022411944 @default.
- W2163283982 cites W2023106874 @default.
- W2163283982 cites W2026725220 @default.
- W2163283982 cites W2027006870 @default.
- W2163283982 cites W2027049216 @default.
- W2163283982 cites W2027176525 @default.
- W2163283982 cites W2027304131 @default.
- W2163283982 cites W2028628438 @default.
- W2163283982 cites W2029023599 @default.
- W2163283982 cites W2029162899 @default.
- W2163283982 cites W2029343225 @default.
- W2163283982 cites W2030358514 @default.
- W2163283982 cites W2031436799 @default.
- W2163283982 cites W2031870719 @default.
- W2163283982 cites W2032297083 @default.
- W2163283982 cites W2032527398 @default.
- W2163283982 cites W2034747473 @default.
- W2163283982 cites W2035136948 @default.
- W2163283982 cites W2036479515 @default.
- W2163283982 cites W2036915173 @default.
- W2163283982 cites W2037290401 @default.
- W2163283982 cites W2037962571 @default.
- W2163283982 cites W2038909026 @default.
- W2163283982 cites W2039042273 @default.
- W2163283982 cites W2041804792 @default.
- W2163283982 cites W2042064755 @default.
- W2163283982 cites W2042912959 @default.
- W2163283982 cites W2043102958 @default.
- W2163283982 cites W2045543635 @default.
- W2163283982 cites W2048986347 @default.
- W2163283982 cites W2053512619 @default.
- W2163283982 cites W2054073416 @default.
- W2163283982 cites W2055520377 @default.
- W2163283982 cites W2055589832 @default.
- W2163283982 cites W2056054156 @default.
- W2163283982 cites W2056568684 @default.
- W2163283982 cites W2059538245 @default.
- W2163283982 cites W2059570418 @default.
- W2163283982 cites W2061377178 @default.
- W2163283982 cites W2061932860 @default.