FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163284793> ?p ?o ?g. }

• W2163284793 endingPage "4346" @default.
• W2163284793 startingPage "4340" @default.
• W2163284793 abstract "ABSTRACT Hepatitis C virus (HCV) infections may be initiated by multiple infectious particles, resulting in a genetically heterogeneous viral population, or by a single particle, leading to a clonal population in the initial stage of infection. To determine which of these scenarios is most common, we evaluated the genetic diversity of HCV quasispecies in 12 seronegative subjects with primary infection following community exposures, six acutely infected recipients of HCV-seropositive blood transfusions and six seropositive individuals with infections of undetermined durations. RNA isolated from plasma and a region of the HCV envelope gene including the first hypervariable region (HVR-1) was reverse transcription-PCR amplified and subcloned, and multiple plasmid clones were sequenced. Phylogenetic analysis indicated that all HCV variants clustered by individuals. Genetic distances among HCV variants within recently infected subjects ranged from 1 to 7.8%. On the basis of the estimated mutation rate of HCV in vivo and the Taq polymerase error rate, primary infection viral quasispecies were classified as genetically heterogeneous when the maximum sequence divergence between genetic variants in the same person was >3%. Heterogeneous quasispecies were detected in 4 of 12 preseroconversion subjects, 1 of 6 transfusion recipients, and 4 of 6 seropositive subjects. The high level of viral quasispecies genetic diversity found in at least a third of recently infected individuals is consistent with the transmission of multiple infectious particles. Community-acquired HCV infection, predominantly the result of needle sharing by injection drug users, therefore appears to be frequently initiated by the successful transmission of multiple viral variants." @default.
• W2163284793 created "2016-06-24" @default.
• W2163284793 creator A5015298131 @default.
• W2163284793 creator A5022601251 @default.
• W2163284793 creator A5062975649 @default.
• W2163284793 creator A5073063058 @default.
• W2163284793 creator A5073398819 @default.
• W2163284793 date "2005-04-01" @default.
• W2163284793 modified "2023-10-02" @default.
• W2163284793 title "Wide Range of Quasispecies Diversity during Primary Hepatitis C Virus Infection" @default.
• W2163284793 cites W102032512 @default.
• W2163284793 cites W1480529641 @default.
• W2163284793 cites W1731793016 @default.
• W2163284793 cites W1965251469 @default.
• W2163284793 cites W1966050666 @default.
• W2163284793 cites W1973155124 @default.
• W2163284793 cites W1980493085 @default.
• W2163284793 cites W1980592095 @default.
• W2163284793 cites W1991018637 @default.
• W2163284793 cites W1996810729 @default.
• W2163284793 cites W1999206566 @default.
• W2163284793 cites W2002394745 @default.
• W2163284793 cites W2003628876 @default.
• W2163284793 cites W2009293979 @default.
• W2163284793 cites W2009366069 @default.
• W2163284793 cites W2012154815 @default.
• W2163284793 cites W2013380601 @default.
• W2163284793 cites W2016778070 @default.
• W2163284793 cites W2017042110 @default.
• W2163284793 cites W2017359325 @default.
• W2163284793 cites W2018555130 @default.
• W2163284793 cites W2037076542 @default.
• W2163284793 cites W2042272201 @default.
• W2163284793 cites W2042618560 @default.
• W2163284793 cites W2043519223 @default.
• W2163284793 cites W2046178003 @default.
• W2163284793 cites W2048996787 @default.
• W2163284793 cites W2052325775 @default.
• W2163284793 cites W2052440478 @default.
• W2163284793 cites W2056839660 @default.
• W2163284793 cites W2058715394 @default.
• W2163284793 cites W2069036111 @default.
• W2163284793 cites W2080416536 @default.
• W2163284793 cites W2082928585 @default.
• W2163284793 cites W2097382368 @default.
• W2163284793 cites W2097585709 @default.
• W2163284793 cites W2102942916 @default.
• W2163284793 cites W2103489598 @default.
• W2163284793 cites W2109464107 @default.
• W2163284793 cites W2111359040 @default.
• W2163284793 cites W2111550532 @default.
• W2163284793 cites W2112251725 @default.
• W2163284793 cites W2113368354 @default.
• W2163284793 cites W2114258096 @default.
• W2163284793 cites W2120479348 @default.
• W2163284793 cites W2120997162 @default.
• W2163284793 cites W2122679529 @default.
• W2163284793 cites W2133269280 @default.
• W2163284793 cites W2134437340 @default.
• W2163284793 cites W2135071517 @default.
• W2163284793 cites W2135389806 @default.
• W2163284793 cites W2137332228 @default.
• W2163284793 cites W2137718170 @default.
• W2163284793 cites W2138477256 @default.
• W2163284793 cites W2139808077 @default.
• W2163284793 cites W2140539990 @default.
• W2163284793 cites W2141128286 @default.
• W2163284793 cites W2141618432 @default.
• W2163284793 cites W2145355617 @default.
• W2163284793 cites W2150789185 @default.
• W2163284793 cites W2154696526 @default.
• W2163284793 cites W2159853150 @default.
• W2163284793 cites W2162278804 @default.
• W2163284793 cites W2163893356 @default.
• W2163284793 cites W2166226314 @default.
• W2163284793 cites W2166454287 @default.
• W2163284793 cites W2168287637 @default.
• W2163284793 cites W2170776372 @default.
• W2163284793 cites W2172226985 @default.
• W2163284793 doi "https://doi.org/10.1128/jvi.79.7.4340-4346.2005" @default.
• W2163284793 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1061543" @default.
• W2163284793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15767434" @default.
• W2163284793 hasPublicationYear "2005" @default.
• W2163284793 type Work @default.
• W2163284793 sameAs 2163284793 @default.
• W2163284793 citedByCount "48" @default.
• W2163284793 countsByYear W21632847932012 @default.
• W2163284793 countsByYear W21632847932013 @default.
• W2163284793 countsByYear W21632847932014 @default.
• W2163284793 countsByYear W21632847932015 @default.
• W2163284793 countsByYear W21632847932016 @default.
• W2163284793 countsByYear W21632847932017 @default.
• W2163284793 countsByYear W21632847932018 @default.
• W2163284793 countsByYear W21632847932019 @default.
• W2163284793 countsByYear W21632847932020 @default.
• W2163284793 countsByYear W21632847932022 @default.
• W2163284793 countsByYear W21632847932023 @default.
• W2163284793 crossrefType "journal-article" @default.

• next