FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163323412> ?p ?o ?g. }

• W2163323412 endingPage "254" @default.
• W2163323412 startingPage "240" @default.
• W2163323412 abstract "SUMMARY Genetic analysis of pancreatic development has provided new insights into the mechanisms underlying the formation of exocrine pancreatic neoplasia. Zebrafish sweetbread (swd) mutants develop hypoplastic acini and dysmorphic ducts in the exocrine pancreas, with impeded progression of cell division cycle and of epithelial growth. Positional cloning and allelic complementation have revealed that the swd mutations affect the transient receptor potential melastatin-subfamily member 7 (trpm7) gene, which encodes a divalent cation-permeable channel with kinase activity. Supplementary Mg2+ partially rescued the exocrine pancreatic defects of the trpm7 mutants by improving cell-cycle progression and growth and repressing the suppressor of cytokine signaling 3a (socs3a) gene. The role of Socs3a in Trpm7-mediated signaling is supported by the findings that socs3a mRNA level is elevated in the trpm7 mutants, and antisense inhibition of socs3a expression improved their exocrine pancreatic growth. TRPM7 is generally overexpressed in human pancreatic adenocarcinoma. TRPM7-deficient cells are impaired in proliferation and arrested in the G0-G1 phases of the cell division cycle. Supplementary Mg2+ rescued the proliferative defect of the TRPM7-deficient cells. Results of this study indicate that Trpm7 regulates exocrine pancreatic development via the Mg2+-sensitive Socs3a pathway, and suggest that aberrant TRPM7-mediated signaling contributes to pancreatic carcinogenesis." @default.
• W2163323412 created "2016-06-24" @default.
• W2163323412 creator A5036381498 @default.
• W2163323412 creator A5039125561 @default.
• W2163323412 creator A5043220508 @default.
• W2163323412 date "2011-03-01" @default.
• W2163323412 modified "2023-09-25" @default.
• W2163323412 title "Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer" @default.
• W2163323412 cites W1559892880 @default.
• W2163323412 cites W1968483542 @default.
• W2163323412 cites W1969645108 @default.
• W2163323412 cites W1971162911 @default.
• W2163323412 cites W1973907258 @default.
• W2163323412 cites W1974948144 @default.
• W2163323412 cites W1977304717 @default.
• W2163323412 cites W1980367714 @default.
• W2163323412 cites W1981520226 @default.
• W2163323412 cites W1992222070 @default.
• W2163323412 cites W1997808089 @default.
• W2163323412 cites W2015376110 @default.
• W2163323412 cites W2018983987 @default.
• W2163323412 cites W2022645001 @default.
• W2163323412 cites W2023641728 @default.
• W2163323412 cites W2024298632 @default.
• W2163323412 cites W2031862161 @default.
• W2163323412 cites W2034227864 @default.
• W2163323412 cites W2038239779 @default.
• W2163323412 cites W2038245668 @default.
• W2163323412 cites W2059813768 @default.
• W2163323412 cites W2060914170 @default.
• W2163323412 cites W2061311681 @default.
• W2163323412 cites W2066581734 @default.
• W2163323412 cites W2068172001 @default.
• W2163323412 cites W2074716607 @default.
• W2163323412 cites W2075727030 @default.
• W2163323412 cites W2078711980 @default.
• W2163323412 cites W2081848364 @default.
• W2163323412 cites W2092480048 @default.
• W2163323412 cites W2092644330 @default.
• W2163323412 cites W2095974369 @default.
• W2163323412 cites W2096690121 @default.
• W2163323412 cites W2099776872 @default.
• W2163323412 cites W2103915598 @default.
• W2163323412 cites W2105164602 @default.
• W2163323412 cites W2110124029 @default.
• W2163323412 cites W2117062067 @default.
• W2163323412 cites W2120896098 @default.
• W2163323412 cites W2128007109 @default.
• W2163323412 cites W2131399935 @default.
• W2163323412 cites W2134811016 @default.
• W2163323412 cites W2135504359 @default.
• W2163323412 cites W2138155367 @default.
• W2163323412 cites W2152698789 @default.
• W2163323412 cites W2156197458 @default.
• W2163323412 cites W2166073081 @default.
• W2163323412 cites W2170175976 @default.
• W2163323412 cites W4233595534 @default.
• W2163323412 doi "https://doi.org/10.1242/dmm.004564" @default.
• W2163323412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3046099" @default.
• W2163323412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21183474" @default.
• W2163323412 hasPublicationYear "2011" @default.
• W2163323412 type Work @default.
• W2163323412 sameAs 2163323412 @default.
• W2163323412 citedByCount "89" @default.
• W2163323412 countsByYear W21633234122012 @default.
• W2163323412 countsByYear W21633234122013 @default.
• W2163323412 countsByYear W21633234122014 @default.
• W2163323412 countsByYear W21633234122015 @default.
• W2163323412 countsByYear W21633234122016 @default.
• W2163323412 countsByYear W21633234122017 @default.
• W2163323412 countsByYear W21633234122018 @default.
• W2163323412 countsByYear W21633234122019 @default.
• W2163323412 countsByYear W21633234122020 @default.
• W2163323412 countsByYear W21633234122021 @default.
• W2163323412 countsByYear W21633234122022 @default.
• W2163323412 countsByYear W21633234122023 @default.
• W2163323412 crossrefType "journal-article" @default.
• W2163323412 hasAuthorship W2163323412A5036381498 @default.
• W2163323412 hasAuthorship W2163323412A5039125561 @default.
• W2163323412 hasAuthorship W2163323412A5043220508 @default.
• W2163323412 hasBestOaLocation W21633234121 @default.
• W2163323412 hasConcept C126322002 @default.
• W2163323412 hasConcept C134018914 @default.
• W2163323412 hasConcept C155164980 @default.
• W2163323412 hasConcept C170493617 @default.
• W2163323412 hasConcept C190283241 @default.
• W2163323412 hasConcept C2778764654 @default.
• W2163323412 hasConcept C29537977 @default.
• W2163323412 hasConcept C502942594 @default.
• W2163323412 hasConcept C53467394 @default.
• W2163323412 hasConcept C54355233 @default.
• W2163323412 hasConcept C62112901 @default.
• W2163323412 hasConcept C62478195 @default.
• W2163323412 hasConcept C71924100 @default.
• W2163323412 hasConcept C86803240 @default.
• W2163323412 hasConcept C95444343 @default.
• W2163323412 hasConceptScore W2163323412C126322002 @default.
• W2163323412 hasConceptScore W2163323412C134018914 @default.

• next