FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163338412> ?p ?o ?g. }

• W2163338412 endingPage "257" @default.
• W2163338412 startingPage "243" @default.
• W2163338412 abstract "In the present study, the 26-residue peptide sequence Ac-KWKSFLKTFKSAKKTVLHTALKAISS-amide (peptide P) was utilized as the framework to study the effects of introducing hydrophilic amino acid lysine on the nonpolar face of the helix on peptide biological activities. Lysine residue was systematically used to substitute original hydrophobic amino acid at the selected locations on the nonpolar face of peptide P. In order to compensate for the loss of hydrophobicity caused by lysine substitution, leucine was also used to replace original alanine to increase peptide overall hydrophobicity. Hemolytic activity is correlated with peptide hydrophobicity. By introducing lysine on the nonpolar face, we significantly weaken peptide hemolytic activity as well as antimicrobial activity. However, by utilizing leucine to compensate the hydrophobicity, we improve antimicrobial activity against both Gram-negative and -positive bacteria. Peptide self-association ability and hydrophobicity were also determined. This specific rational approach of peptide design could be a powerful method to optimize antimicrobial peptides with clinical potential as peptide antibiotics." @default.
• W2163338412 created "2016-06-24" @default.
• W2163338412 creator A5012265390 @default.
• W2163338412 creator A5021126037 @default.
• W2163338412 creator A5022072267 @default.
• W2163338412 creator A5036894207 @default.
• W2163338412 creator A5052994285 @default.
• W2163338412 creator A5061140388 @default.
• W2163338412 date "2010-01-03" @default.
• W2163338412 modified "2023-10-18" @default.
• W2163338412 title "Structure-guided de novo design of α-helical antimicrobial peptide with enhanced specificity" @default.
• W2163338412 cites W1278793486 @default.
• W2163338412 cites W1976301815 @default.
• W2163338412 cites W1978563602 @default.
• W2163338412 cites W1980595924 @default.
• W2163338412 cites W1982258330 @default.
• W2163338412 cites W2003897459 @default.
• W2163338412 cites W2017968349 @default.
• W2163338412 cites W2047524425 @default.
• W2163338412 cites W2054602599 @default.
• W2163338412 cites W2056123667 @default.
• W2163338412 cites W2082790072 @default.
• W2163338412 cites W2084082061 @default.
• W2163338412 cites W2087125825 @default.
• W2163338412 cites W2092259583 @default.
• W2163338412 cites W2126224226 @default.
• W2163338412 cites W2133056039 @default.
• W2163338412 cites W2145344160 @default.
• W2163338412 cites W2158482458 @default.
• W2163338412 doi "https://doi.org/10.1351/pac-con-09-01-12" @default.
• W2163338412 hasPublicationYear "2010" @default.
• W2163338412 type Work @default.
• W2163338412 sameAs 2163338412 @default.
• W2163338412 citedByCount "24" @default.
• W2163338412 countsByYear W21633384122012 @default.
• W2163338412 countsByYear W21633384122013 @default.
• W2163338412 countsByYear W21633384122014 @default.
• W2163338412 countsByYear W21633384122015 @default.
• W2163338412 countsByYear W21633384122016 @default.
• W2163338412 countsByYear W21633384122018 @default.
• W2163338412 countsByYear W21633384122019 @default.
• W2163338412 countsByYear W21633384122021 @default.
• W2163338412 countsByYear W21633384122022 @default.
• W2163338412 countsByYear W21633384122023 @default.
• W2163338412 crossrefType "journal-article" @default.
• W2163338412 hasAuthorship W2163338412A5012265390 @default.
• W2163338412 hasAuthorship W2163338412A5021126037 @default.
• W2163338412 hasAuthorship W2163338412A5022072267 @default.
• W2163338412 hasAuthorship W2163338412A5036894207 @default.
• W2163338412 hasAuthorship W2163338412A5052994285 @default.
• W2163338412 hasAuthorship W2163338412A5061140388 @default.
• W2163338412 hasBestOaLocation W21633384121 @default.
• W2163338412 hasConcept C104317684 @default.
• W2163338412 hasConcept C167625842 @default.
• W2163338412 hasConcept C178790620 @default.
• W2163338412 hasConcept C185592680 @default.
• W2163338412 hasConcept C21951064 @default.
• W2163338412 hasConcept C2776016237 @default.
• W2163338412 hasConcept C2776580952 @default.
• W2163338412 hasConcept C2779281246 @default.
• W2163338412 hasConcept C2779809887 @default.
• W2163338412 hasConcept C2779856020 @default.
• W2163338412 hasConcept C2781338088 @default.
• W2163338412 hasConcept C2994376932 @default.
• W2163338412 hasConcept C4937899 @default.
• W2163338412 hasConcept C515207424 @default.
• W2163338412 hasConcept C540938839 @default.
• W2163338412 hasConcept C55493867 @default.
• W2163338412 hasConcept C71240020 @default.
• W2163338412 hasConceptScore W2163338412C104317684 @default.
• W2163338412 hasConceptScore W2163338412C167625842 @default.
• W2163338412 hasConceptScore W2163338412C178790620 @default.
• W2163338412 hasConceptScore W2163338412C185592680 @default.
• W2163338412 hasConceptScore W2163338412C21951064 @default.
• W2163338412 hasConceptScore W2163338412C2776016237 @default.
• W2163338412 hasConceptScore W2163338412C2776580952 @default.
• W2163338412 hasConceptScore W2163338412C2779281246 @default.
• W2163338412 hasConceptScore W2163338412C2779809887 @default.
• W2163338412 hasConceptScore W2163338412C2779856020 @default.
• W2163338412 hasConceptScore W2163338412C2781338088 @default.
• W2163338412 hasConceptScore W2163338412C2994376932 @default.
• W2163338412 hasConceptScore W2163338412C4937899 @default.
• W2163338412 hasConceptScore W2163338412C515207424 @default.
• W2163338412 hasConceptScore W2163338412C540938839 @default.
• W2163338412 hasConceptScore W2163338412C55493867 @default.
• W2163338412 hasConceptScore W2163338412C71240020 @default.
• W2163338412 hasIssue "1" @default.
• W2163338412 hasLocation W21633384121 @default.
• W2163338412 hasOpenAccess W2163338412 @default.
• W2163338412 hasPrimaryLocation W21633384121 @default.
• W2163338412 hasRelatedWork W1990648658 @default.
• W2163338412 hasRelatedWork W1993795649 @default.
• W2163338412 hasRelatedWork W2027352683 @default.
• W2163338412 hasRelatedWork W2037013300 @default.
• W2163338412 hasRelatedWork W2044427462 @default.
• W2163338412 hasRelatedWork W2163338412 @default.
• W2163338412 hasRelatedWork W2417630359 @default.
• W2163338412 hasRelatedWork W2950555525 @default.

• next