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- W2163347689 abstract "To test whether variants in SPINK5(57 SNPs), associated with skin barrier function, and IL-13(7 SNPs), a key cytokine implicated in allergic sensitization, increase the risk of food sensitization(FS) and/or food allergy(FA) in a cohort of children diagnosed for FA by skin prick testing and oral food challenge. SNPs were tested in logistic regression models for three groups; FA, FS tolerant and non-allergic among 12 month infants (n=835) recruited as part of HealthNuts, a longitudinal, population based study of FA in Melbourne, Australia. Buccal-derived genomic DNA was genotyped using Sequenom iPLEX. A single SPINK5 variant, rs6580514 A->G was associated with a ∼40% decreased risk of FA compared to negative controls (p=0.017) and FS (p=0.008). In contrast, two SPINK5 variants: rs1860933 T->A (p=0.014) & rs1432975 A->T (p=0.033), conferred a significantly increased risk of FA. Eight SPINK5 SNPs were associated with a significantly elevated risk of FA compared to FS individuals. The IL-13 SNP, rs1295687 C->G (p=0.016), was found to increase the risk of FS by more than 2.5 fold and was also associated with elevated IL-13 cytokine levels in response to allergenic stimulation (p<0.05). The protective and risk odds of FA associated with several SPINK5 SNPs strongly support a role of skin barrier integrity in both protecting against, or in the case of disrupted skin, increasing the risk of allergic sensitization. These findings mirror those of FLG variants, known to influence skin barrier function, previously implicated in allergic sensitization." @default.
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- W2163347689 date "2015-02-01" @default.
- W2163347689 modified "2023-09-26" @default.
- W2163347689 title "Skin Barrier Function and Candidate Genes IL-13 & SPINK5 in Food Allergy" @default.
- W2163347689 doi "https://doi.org/10.1016/j.jaci.2014.12.1882" @default.
- W2163347689 hasPublicationYear "2015" @default.
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