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- W2163349610 abstract "We study MCF-7 breast cancer cell movement in a transwell apparatus. Various experimental conditions lead to a variety of monotone and nonmonotone responses which are difficult to interpret. We anticipate that the experimental results could be caused by cell-to-cell adhesion or volume exclusion. Without any modeling, it is impossible to understand the relative roles played by these two mechanisms. A lattice-based exclusion process random-walk model incorporating agent-to-agent adhesion is applied to the experimental system. Our combined experimental and modeling approach shows that a low value of cell-to-cell adhesion strength provides the best explanation of the experimental data suggesting that volume exclusion plays a more important role than cell-to-cell adhesion. This combined experimental and modeling study gives insight into the cell-level details and design of transwell assays." @default.
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- W2163349610 date "2010-10-01" @default.
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- W2163349610 title "Migration of breast cancer cells: Understanding the roles of volume exclusion and cell-to-cell adhesion" @default.
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- W2163349610 doi "https://doi.org/10.1103/physreve.82.041901" @default.
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