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- W2163372722 abstract "Abstract Ethoxyresorufin O-deethylase activities of individual isolated hepatocytes, from control or 3-methylcholanthrene pretreated rats, were measured by a new direct microfluorimetric method. There was a wide inter-individual variation in ethoxyresorufin O-deethylase activity among the hepatocytes isolated from a 3-methylcholanthrene pretreated rat. The mean activity for a sample of eighty individual hepatocytes from a 3-methylcholanthrene pretreated rat was 0.8 × 10−3 pmoles/min/cell, with a spread of activities of approximately 0.2–2.7 × 10−3 pmoles/min/cell. In contrast, there was only a very small intercellular variation in the much lower deethylase activities of hepatocytes from a control rat, with a mean activity of 0.01 × 10−3 pmoles/min/cell. The mean ethoxyresorufin O-deethylase activity of a sample of individual hepatocytes isolated from a 3-methylcholanthrene pretreated rat was inhibited approximately 60 per cent by 12.5 μM α-naphthoflavone but was inhibited only approximately 22 per cent by 125 μM metyrapone." @default.
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- W2163372722 date "1978-01-01" @default.
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- W2163372722 title "Microfluoremetric analysis of the cytochrome P448 associated, ethoxyresorufin O-deethylase activities of individual isolated rat hepatocytes" @default.
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- W2163372722 doi "https://doi.org/10.1016/0006-2952(78)90482-3" @default.
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