FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163389258> ?p ?o ?g. }

• W2163389258 endingPage "1968" @default.
• W2163389258 startingPage "1960" @default.
• W2163389258 abstract "Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules. To explore the basis of dinitroaniline action, we isolated 49 independent resistant Toxoplasma gondii lines after chemical mutagenesis. All 23 of the lines that we examined harbored single point mutations in alpha-tubulin. These point mutations were sufficient to confer resistance when transfected into wild-type parasites. Several mutations were in the M or N loops, which coordinate protofilament interactions in the microtubule, but most of the mutations were in the core of alpha-tubulin. Docking studies predict that oryzalin binds with an average affinity of 23 nM to a site located beneath the N loop of Toxoplasma alpha-tubulin. This binding site included residues that were mutated in several resistant lines. Moreover, parallel analysis of Bos taurus alpha-tubulin indicated that oryzalin did not interact with this site and had a significantly decreased, nonspecific affinity for vertebrate alpha-tubulin. We propose that the dinitroanilines act through a novel mechanism, by disrupting M-N loop contacts. These compounds also represent the first class of drugs that act on alpha-tubulin function." @default.
• W2163389258 created "2016-06-24" @default.
• W2163389258 creator A5016766054 @default.
• W2163389258 creator A5023378358 @default.
• W2163389258 creator A5032841072 @default.
• W2163389258 creator A5064168529 @default.
• W2163389258 date "2004-04-01" @default.
• W2163389258 modified "2023-10-16" @default.
• W2163389258 title "Dinitroanilines Bind α-Tubulin to Disrupt Microtubules" @default.
• W2163389258 cites W1481682126 @default.
• W2163389258 cites W1525759724 @default.
• W2163389258 cites W1556742432 @default.
• W2163389258 cites W1580003617 @default.
• W2163389258 cites W1681126520 @default.
• W2163389258 cites W181228338 @default.
• W2163389258 cites W1865434470 @default.
• W2163389258 cites W1883565401 @default.
• W2163389258 cites W1922262698 @default.
• W2163389258 cites W1970719708 @default.
• W2163389258 cites W1982485940 @default.
• W2163389258 cites W1982947338 @default.
• W2163389258 cites W1988369885 @default.
• W2163389258 cites W1994345832 @default.
• W2163389258 cites W1995607214 @default.
• W2163389258 cites W2009486292 @default.
• W2163389258 cites W2015642465 @default.
• W2163389258 cites W2015710784 @default.
• W2163389258 cites W2029076396 @default.
• W2163389258 cites W2029687996 @default.
• W2163389258 cites W2035313977 @default.
• W2163389258 cites W2046175020 @default.
• W2163389258 cites W2047330279 @default.
• W2163389258 cites W2048188756 @default.
• W2163389258 cites W2052538813 @default.
• W2163389258 cites W2058101090 @default.
• W2163389258 cites W2058997498 @default.
• W2163389258 cites W2062795675 @default.
• W2163389258 cites W2063110176 @default.
• W2163389258 cites W2073496431 @default.
• W2163389258 cites W2078909808 @default.
• W2163389258 cites W2092697567 @default.
• W2163389258 cites W2101898282 @default.
• W2163389258 cites W2103815459 @default.
• W2163389258 cites W2105615050 @default.
• W2163389258 cites W2105930041 @default.
• W2163389258 cites W2113087609 @default.
• W2163389258 cites W2113982265 @default.
• W2163389258 cites W2114009421 @default.
• W2163389258 cites W2117931147 @default.
• W2163389258 cites W2118511327 @default.
• W2163389258 cites W2122741144 @default.
• W2163389258 cites W2123209344 @default.
• W2163389258 cites W2128172847 @default.
• W2163389258 cites W2132717858 @default.
• W2163389258 cites W2136464519 @default.
• W2163389258 cites W2138447445 @default.
• W2163389258 cites W2140197466 @default.
• W2163389258 cites W2144786472 @default.
• W2163389258 cites W2145486096 @default.
• W2163389258 cites W2151387311 @default.
• W2163389258 cites W2158534713 @default.
• W2163389258 cites W2172831970 @default.
• W2163389258 cites W4321258522 @default.
• W2163389258 doi "https://doi.org/10.1091/mbc.e03-07-0530" @default.
• W2163389258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/379290" @default.
• W2163389258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14742718" @default.
• W2163389258 hasPublicationYear "2004" @default.
• W2163389258 type Work @default.
• W2163389258 sameAs 2163389258 @default.
• W2163389258 citedByCount "140" @default.
• W2163389258 countsByYear W21633892582012 @default.
• W2163389258 countsByYear W21633892582013 @default.
• W2163389258 countsByYear W21633892582014 @default.
• W2163389258 countsByYear W21633892582015 @default.
• W2163389258 countsByYear W21633892582016 @default.
• W2163389258 countsByYear W21633892582017 @default.
• W2163389258 countsByYear W21633892582018 @default.
• W2163389258 countsByYear W21633892582019 @default.
• W2163389258 countsByYear W21633892582020 @default.
• W2163389258 countsByYear W21633892582021 @default.
• W2163389258 countsByYear W21633892582022 @default.
• W2163389258 countsByYear W21633892582023 @default.
• W2163389258 crossrefType "journal-article" @default.
• W2163389258 hasAuthorship W2163389258A5016766054 @default.
• W2163389258 hasAuthorship W2163389258A5023378358 @default.
• W2163389258 hasAuthorship W2163389258A5032841072 @default.
• W2163389258 hasAuthorship W2163389258A5064168529 @default.
• W2163389258 hasBestOaLocation W21633892582 @default.
• W2163389258 hasConcept C104317684 @default.
• W2163389258 hasConcept C143065580 @default.
• W2163389258 hasConcept C153911025 @default.
• W2163389258 hasConcept C16318435 @default.
• W2163389258 hasConcept C176944494 @default.
• W2163389258 hasConcept C20418707 @default.
• W2163389258 hasConcept C2778098538 @default.
• W2163389258 hasConcept C54355233 @default.
• W2163389258 hasConcept C84425145 @default.
• W2163389258 hasConcept C86803240 @default.

• next