FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2163391438> ?p ?o ?g. }

• W2163391438 endingPage "15" @default.
• W2163391438 startingPage "9" @default.
• W2163391438 abstract "SUMMARY Sera from prospective transplant patients are usually screened for HLA antibodies prior to transplantation, but presently available tests do not permit quantification of the humoral alloantigen directed response. We adapted a culture system for isolated human B-lymphocytes to assay the secretion of HLA-antibodies on a single cell basis. B-cell supernatants were screened for HLA antibodies by complement dependent cytotoxicity. The assay assigns precursor frequencies for HLA-alloantibody secreting B-lymphocytes (BCPFs), and simultaneously allows for dissection of the humoral alloantigen directed response into its monoclonal components. The lymphocytes of 15 HLA-seropositive multiparous women that were used to validate the assay, were found to contain HLA-BCPFs ranging from 0 to 123 per 106 B-lymphocytes (mean: 43 ± 45 per 106 B-lymphocytes). The HLA-specificities of antibodies in the B-cell supernatants were in agreement with serum specificities. Genuine HLA reactivity of B-cell supernatants was confirmed using an ELISA with purified HLA class I antigens. When applied to lymphocytes of patients on transplant waiting lists, the present assay may enable the unraveling of serum specificities in their components, thus supplementing HLA antibody serum screening data." @default.
• W2163391438 created "2016-06-24" @default.
• W2163391438 creator A5003949861 @default.
• W2163391438 creator A5021544227 @default.
• W2163391438 creator A5038677115 @default.
• W2163391438 creator A5045144667 @default.
• W2163391438 creator A5048355604 @default.
• W2163391438 creator A5075175060 @default.
• W2163391438 creator A5080202209 @default.
• W2163391438 date "2001-04-01" @default.
• W2163391438 modified "2023-10-03" @default.
• W2163391438 title "Determination of the frequency of HLA antibody secreting B-lymphocytes in alloantigen sensitized individuals" @default.
• W2163391438 cites W1502613791 @default.
• W2163391438 cites W1534887038 @default.
• W2163391438 cites W1557517307 @default.
• W2163391438 cites W1756135215 @default.
• W2163391438 cites W1970490255 @default.
• W2163391438 cites W1972873143 @default.
• W2163391438 cites W1982657150 @default.
• W2163391438 cites W1986445400 @default.
• W2163391438 cites W1987825416 @default.
• W2163391438 cites W1991071771 @default.
• W2163391438 cites W2005985173 @default.
• W2163391438 cites W2015800825 @default.
• W2163391438 cites W2024501042 @default.
• W2163391438 cites W2025498861 @default.
• W2163391438 cites W2039787192 @default.
• W2163391438 cites W2043027099 @default.
• W2163391438 cites W2045177413 @default.
• W2163391438 cites W2060212403 @default.
• W2163391438 cites W2064119306 @default.
• W2163391438 cites W2074619523 @default.
• W2163391438 cites W2076126202 @default.
• W2163391438 cites W2076621710 @default.
• W2163391438 cites W2080678103 @default.
• W2163391438 cites W2083333282 @default.
• W2163391438 cites W2083491909 @default.
• W2163391438 cites W2089800576 @default.
• W2163391438 cites W2109189272 @default.
• W2163391438 cites W2119691417 @default.
• W2163391438 cites W2151222193 @default.
• W2163391438 cites W2257875872 @default.
• W2163391438 cites W2324342306 @default.
• W2163391438 cites W2394850763 @default.
• W2163391438 cites W2462656461 @default.
• W2163391438 cites W4252971378 @default.
• W2163391438 cites W4313347819 @default.
• W2163391438 doi "https://doi.org/10.1046/j.1365-2249.2001.01497.x" @default.
• W2163391438 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1906029" @default.
• W2163391438 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11359437" @default.
• W2163391438 hasPublicationYear "2001" @default.
• W2163391438 type Work @default.
• W2163391438 sameAs 2163391438 @default.
• W2163391438 citedByCount "31" @default.
• W2163391438 countsByYear W21633914382012 @default.
• W2163391438 countsByYear W21633914382013 @default.
• W2163391438 countsByYear W21633914382014 @default.
• W2163391438 countsByYear W21633914382015 @default.
• W2163391438 countsByYear W21633914382016 @default.
• W2163391438 countsByYear W21633914382018 @default.
• W2163391438 countsByYear W21633914382019 @default.
• W2163391438 countsByYear W21633914382020 @default.
• W2163391438 crossrefType "journal-article" @default.
• W2163391438 hasAuthorship W2163391438A5003949861 @default.
• W2163391438 hasAuthorship W2163391438A5021544227 @default.
• W2163391438 hasAuthorship W2163391438A5038677115 @default.
• W2163391438 hasAuthorship W2163391438A5045144667 @default.
• W2163391438 hasAuthorship W2163391438A5048355604 @default.
• W2163391438 hasAuthorship W2163391438A5075175060 @default.
• W2163391438 hasAuthorship W2163391438A5080202209 @default.
• W2163391438 hasBestOaLocation W21633914382 @default.
• W2163391438 hasConcept C109316439 @default.
• W2163391438 hasConcept C126322002 @default.
• W2163391438 hasConcept C147483822 @default.
• W2163391438 hasConcept C159654299 @default.
• W2163391438 hasConcept C188280979 @default.
• W2163391438 hasConcept C202751555 @default.
• W2163391438 hasConcept C203014093 @default.
• W2163391438 hasConcept C2776548049 @default.
• W2163391438 hasConcept C2778453870 @default.
• W2163391438 hasConcept C2911091166 @default.
• W2163391438 hasConcept C542903549 @default.
• W2163391438 hasConcept C55493867 @default.
• W2163391438 hasConcept C71924100 @default.
• W2163391438 hasConcept C86803240 @default.
• W2163391438 hasConceptScore W2163391438C109316439 @default.
• W2163391438 hasConceptScore W2163391438C126322002 @default.
• W2163391438 hasConceptScore W2163391438C147483822 @default.
• W2163391438 hasConceptScore W2163391438C159654299 @default.
• W2163391438 hasConceptScore W2163391438C188280979 @default.
• W2163391438 hasConceptScore W2163391438C202751555 @default.
• W2163391438 hasConceptScore W2163391438C203014093 @default.
• W2163391438 hasConceptScore W2163391438C2776548049 @default.
• W2163391438 hasConceptScore W2163391438C2778453870 @default.
• W2163391438 hasConceptScore W2163391438C2911091166 @default.
• W2163391438 hasConceptScore W2163391438C542903549 @default.
• W2163391438 hasConceptScore W2163391438C55493867 @default.
• W2163391438 hasConceptScore W2163391438C71924100 @default.

• next